3-FORMYL-1H-INDOLE-6-CARBONITRILE
- Product Name
- 3-FORMYL-1H-INDOLE-6-CARBONITRILE
- CAS No.
- 83783-33-9
- Chemical Name
- 3-FORMYL-1H-INDOLE-6-CARBONITRILE
- Synonyms
- 3-ForMyl-6-cyano-1H-indole;3-FORMYL-1H-INDOLE-6-CARBONITRILE;1H-Indole-6-carbonitrile, 3-formyl-
- CBNumber
- CB5351266
- Molecular Formula
- C10H6N2O
- Formula Weight
- 170.17
- MOL File
- Mol file
3-FORMYL-1H-INDOLE-6-CARBONITRILE Property
- Boiling point:
- 429.6±25.0 °C(Predicted)
- Density
- 1.33±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- solid
- pka
- 13.67±0.30(Predicted)
- Appearance
- Light yellow to yellow Solid
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- PHB00304
- Product name
- 3-Formyl-6-cyano-1H-indole
- Purity
- AldrichCPR
- Packaging
- 1 g
- Price
- $87.5
- Updated
- 2025/07/31
- Product number
- B414228
- Product name
- 3-Formyl-1H-indole-6-carbonitrile
- Packaging
- 500mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- OR931695
- Product name
- 3-Formyl-1H-indole-6-carbonitrile
- Purity
- >98%
- Packaging
- 5g
- Price
- $589
- Updated
- 2021/12/16
- Product number
- 4H37-1-0E
- Product name
- 3-Formyl-1H-indole-6-carbonitrile
- Purity
- 97%
- Packaging
- 5G
- Price
- $375
- Updated
- 2021/12/16
- Product number
- W8680
- Product name
- 3-Formyl-1H-indole-6-carbonitrile
- Packaging
- 10g
- Price
- $493
- Updated
- 2021/12/16
3-FORMYL-1H-INDOLE-6-CARBONITRILE Chemical Properties,Usage,Production
Synthesis
15861-36-6
68-12-2
83783-33-9
a) Synthesis of 3-formyl-1H-indole-6-carbonitrile: Under stirring conditions, phosphorus oxychloride (POCl3, 0.593 g, 3.87 mmol) was slowly added dropwise to 5 mL of N,N-dimethylformamide (DMF). After stirring for 10 min, 6-cyanoindole (1H-indole-6-carbonitrile, 0.500 g, 3.52 mmol) was added in batches. The reaction mixture was stirred at room temperature for 1 hour, followed by warming up to 40°C and continued stirring for 1 hour. Upon completion of the reaction, the mixture was poured into ice water and adjusted to alkaline with aqueous sodium hydroxide. The mixture was then heated to 100 °C for 1 min, cooled again in an ice bath and extracted three times with ethyl acetate (EtOAc). The organic layers were combined, washed with water, dried over anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure. The crude product was recrystallized by water-ethanol mixed solvent to give the target product 3-formyl-1H-indole-6-carbonitrile 0.379 g in 63% yield. The product was characterized by 1H NMR (500 MHz, MeOH-d4): δ 9.98 (s, 1H), 8.33 (s, 1H), 8.31 (d, 1H), 7.89 (m, 1H), 7.52 (m, 1H).
References
[1] Patent: WO2005/66132, 2005, A1. Location in patent: Page/Page column 67
[2] Journal of Medicinal Chemistry, 1983, vol. 26, # 2, p. 294 - 298
[3] Bioorganic and Medicinal Chemistry Letters, 1996, vol. 6, # 1, p. 81 - 86
[4] Journal of Medicinal Chemistry, 1997, vol. 40, # 18, p. 2843 - 2857
[5] Patent: WO2009/153307, 2009, A1. Location in patent: Page/Page column 38-39
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