4-BROMO-3,5-DIMETHOXYBENZYL ALCOHOL
- Product Name
- 4-BROMO-3,5-DIMETHOXYBENZYL ALCOHOL
- CAS No.
- 61367-62-2
- Chemical Name
- 4-BROMO-3,5-DIMETHOXYBENZYL ALCOHOL
- Synonyms
- 5-DIMETHOXYBENZYL ALCOHOL;4-BROMO-3,5-DIMETHOXYBENZYL ALCOHOL;4-Bromo-3,5-dimethoxybenzenemethanol;4-BROMO-3,5-DIMETHOXY-PHENYL)-METHANOL;4-Bromo-3,5-dimethoxybenzyl alcohol 98%;Benzenemethanol, 4-bromo-3,5-dimethoxy-
- CBNumber
- CB5351271
- Molecular Formula
- C9H11BrO3
- Formula Weight
- 247.09
- MOL File
- 61367-62-2.mol
4-BROMO-3,5-DIMETHOXYBENZYL ALCOHOL Property
- Melting point:
- 100-102℃
- Boiling point:
- 348.1±37.0 °C(Predicted)
- Density
- 1.475±0.06 g/cm3 (20 ºC 760 Torr)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 13.85±0.10(Predicted)
- Appearance
- White to off-white Solid
- CAS DataBase Reference
- 61367-62-2(CAS DataBase Reference)
Safety
- HS Code
- 2906290090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B691468
- Product name
- 4-Bromo-3,5-dimethoxybenzylalcohol
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- B691468
- Product name
- 4-Bromo-3,5-dimethoxybenzylalcohol
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- FB70812
- Product name
- 4-Bromo-3,5-dimethoxybenzyl alcohol
- Packaging
- 25g
- Price
- $100
- Updated
- 2021/12/16
- Product number
- Q020
- Product name
- 4-Bromo-3,5-dimethoxybenzylalcohol
- Packaging
- 1g
- Price
- $11
- Updated
- 2021/12/16
- Product number
- 2707-9-00
- Product name
- 4-Bromo-3,5-dimethoxybenzyl alcohol
- Packaging
- 5G
- Price
- $119
- Updated
- 2021/12/16
4-BROMO-3,5-DIMETHOXYBENZYL ALCOHOL Chemical Properties,Usage,Production
Synthesis Reference(s)
Journal of Medicinal Chemistry, 20, p. 299, 1977 DOI: 10.1021/jm00212a022
Synthesis
26050-64-6
61367-62-2
General procedure for the synthesis of 4-bromo-3,5-dimethoxybenzenemethanol from methyl 4-bromo-3,5-dimethoxybenzoate: a solution of LiAlH4 (4.43 g, 0.12 mol) in freshly distilled anhydrous THF (45 mL) was added slowly and dropwise to a stirring 4-bromo-3,5-dimethoxybenzoic acid methyl ester (5.48 g, 0.02 mol) in a THF (80 mL) solution. The reaction mixture was stirred at 0 °C for 15 min, followed by recovery to room temperature and continued stirring for 8 h. The reaction was completed with the use of saturated chlorine chloride. Upon completion of the reaction, the reaction was quenched with saturated ammonium chloride solution (140 mL), stirred for 1 h, acidified with dilute hydrochloric acid and extracted with ethyl acetate (3 x 25 mL). The organic phases were combined, the solvents were evaporated after drying, and the resulting crude product was recrystallized from petroleum ether to give 4-bromo-3,5-dimethoxybenzyl alcohol as colorless prismatic crystals (4.42 g, 90% yield). The product was characterized as follows: Rf = 0.35; melting point 96-97 °C (literature value 34a, 100-102 °C); IR (KBr) νmax: 3362 (O-H), 3024 (C=C-H), 1574 (C=C) cm-1; 1H NMR (300 MHz, CDCl3) δ 6.50 (2H, s, H-2, H-6), and 4.57 (2H, s, ArCH2), 3.75 (6H, s, OCH3), 2.48 (1H, s, OH) ppm; 13C NMR (CDCl3) δ: 158.3 (C-3,5), 142.7 (C-1), 121.7 (C-4), 112.5 (C-2,6), 63.3 (OCH3), 62.0 ( OCH3), 42.1 (CH2) ppm. elemental analysis (C9H11BrO3) Calculated: C, 43.70; H, 4.48; Measured: C, 43.70; H, 4.24. GC-MS m/z 245.9, 247.9.
References
[1] Tetrahedron, 2014, vol. 70, # 7, p. 1401 - 1407
[2] Patent: US2005/59733, 2005, A1
[3] European Journal of Organic Chemistry, 2002, # 19, p. 3294 - 3303
[4] Journal of Medicinal Chemistry, 1977, vol. 20, # 2, p. 299 - 301
[5] Patent: WO2003/72536, 2003, A1. Location in patent: Page/Page column 26-27
4-BROMO-3,5-DIMETHOXYBENZYL ALCOHOL Preparation Products And Raw materials
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View Lastest Price from 4-BROMO-3,5-DIMETHOXYBENZYL ALCOHOL manufacturers
- Product
- 4-BROMO-3,5-DIMETHOXYBENZYL ALCOHOL 61367-62-2
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-14
- Product
- 4-Bromo-3,5-dimethoxybenzyl alcohol 61367-62-2
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- kgs
- Release date
- 2023-02-17
- Product
- 4-Bromo-3,5-dimethoxybenzyl alcohol 61367-62-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 200kgs
- Release date
- 2020-01-09