ChemicalBook > CAS DataBase List > DIHYDROCYCLOSPORIN A

DIHYDROCYCLOSPORIN A

Product Name
DIHYDROCYCLOSPORIN A
CAS No.
59865-15-5
Chemical Name
DIHYDROCYCLOSPORIN A
Synonyms
CS-2523;Cyclosporin EP B;Dihydrocyclosporin;Capecitabine Imp.G;DIHYDROCYCLOSPORIN A;Dihydrocyclosporine A;Cyclosporin Impurity 10;Cyclosporine Impurity 10;Ciclosporin EP impurity B;Dihydrocyclosporin A reference
CBNumber
CB5352728
Molecular Formula
C62H113N11O12
Formula Weight
1204.63
MOL File
59865-15-5.mol
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DIHYDROCYCLOSPORIN A Property

Melting point:
120-125?C
Boiling point:
1285.3±65.0 °C(Predicted)
Density 
1.012±0.06 g/cm3(Predicted)
storage temp. 
Refrigerator
solubility 
Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
form 
Solid
pka
13.33±0.70(Predicted)
color 
White
InChIKey
TYFOVYYNQGNDKH-AAJDKDKZNA-N
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H350May cause cancer

H362May cause harm to breast-fed children

Precautionary statements

P201Obtain special instructions before use.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P263Avoid contact during pregnancy/while nursing.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P308+P313IF exposed or concerned: Get medical advice/attention.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
D448865
Product name
DihydroCyclosporinA
Packaging
5mg
Price
$130
Updated
2021/12/16
Usbiological
Product number
D3801-01
Product name
Dihydrocyclosporin A
Packaging
1mg
Price
$362
Updated
2021/12/16
TRC
Product number
D448865
Product name
DihydroCyclosporinA
Packaging
100mg
Price
$1480
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0002365
Product name
DIHYDROCYCLOSPORIN A
Purity
95.00%
Packaging
100MG
Price
$1732.5
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD21913
Product name
Dihydrocyclosporin A
Packaging
25mg
Price
$700
Updated
2021/12/16
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DIHYDROCYCLOSPORIN A Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

Dihydrocyclosporin A is a closely related co-metabolite of cyclosporin A. Dihydrocyclosporin A possesses no immunosuppressant activity and has found use as a control to determine the role of immunosuppression in the pharmacology of cyclosporin A, particularly in the treatment of parasitic infections.

Uses

Dihydrocyclosporin A (DHCsA-d) is cyclosporine A (CsA) derivative. DHCsA-d significantly inhibited promastigotes and intracellular amastigotes, but it is highly cytotoxic.

Uses

A Cyclosporin A (C988900) analog, an immunosuppressant.

Side effects

Dihydrocyclosporine A has no obvious nephrotoxic effect, but it exhibits hepatotoxic effects, often leading to hypertension.

DIHYDROCYCLOSPORIN A Preparation Products And Raw materials

Raw materials

Preparation Products

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DIHYDROCYCLOSPORIN A Suppliers

Canada 1 China 75 India 5 United Kingdom 2 United States 11 Global 94
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59865-15-5, DIHYDROCYCLOSPORIN ARelated Search:

DIHYDROCYCLOSPORIN C dihydrocyclosporin D Dihydrocyclosporin E DIHYDROCYCLOSPORIN A CYCLOSPORIN J

  • DIHYDROCYCLOSPORIN A
  • Dihydrocyclosporin
  • (3R,4R)-3-Hydroxy-4,N-dimethyl-5-propylcyclo[L-Nva-L-Abu-Sar-N-methyl-L-Leu-L-Val-N-methyl-L-Leu-L-Ala-D-Ala-N-methyl-L-Leu-N-methyl-L-Leu-N-methyl-L-Val-]
  • (3R,4R)-3-Hydroxy-N-methyl-5-propylcyclo(L-Leu-L-Abu-Sar-N-methyl-L-Leu-L-Val-N-methyl-L-Leu-L-Ala-D-Ala-N-methyl-L-Leu-N-methyl-L-Leu-N-methyl-L-Val-)
  • 6-[(2S,3R,4R)-3-Hydroxy-4-Methyl-2-(MethylaMino)octanoic acid]cyclosporin A
  • Cyclosporin A Dihydro IMpurity
  • Dihydrocyclosporine A
  • Cyclosporin Impurity 10
  • Dihydrocyclosporin A reference
  • Dihydrocyclosporine A/6-[(2S,3R,4R)-3-Hydroxy-4-methyl-2-(methylamino)octanoic acid]cyclosporin A
  • CS-2523
  • Cyclosporin Impurity 10（Dihydrocyclosporin A）
  • Cyclosporin A,6-[(2S,3R,4R)-3-hydroxy-4-methyl-2-(methylamino)octanoic acid]-
  • Capecitabine Imp.G
  • Cyclosporine Impurity 10
  • Ciclosporin EP impurity B
  • Cyclosporin Impurity 10(Dihydrocyclosporin A)(Ciclosporin EP Impurity B)
  • Ciclosporin EP Impurity B (Dihydrocyclosporin A)
  • Cyclosporin EP B
  • (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33-[(1R,2R)-1-hydroxy-2-methylhexyl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-bis(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecone
  • 59865-15-5
  • C62H113N11O12
  • Intermediates & Fine Chemicals
  • Peptides
  • Pharmaceuticals