(5-METHYLPYRIDIN-3-YL)METHANOL
- Product Name
- (5-METHYLPYRIDIN-3-YL)METHANOL
- CAS No.
- 102074-19-1
- Chemical Name
- (5-METHYLPYRIDIN-3-YL)METHANOL
- Synonyms
- Fumarate Impurity 1;Rupatadine impurity 3;Fumarate R Impurity 1;Lupatadine Impurity 5;5-methy-3-pyridylmethanol;5-Methyl-3-pyridineMethano;Nicotine Related Compound 3;5-Methylpyridine-3-Methanol;3-methylpyridine-5-methanol;Piperidine,1-(3-butyn-4-yl)-
- CBNumber
- CB5353437
- Molecular Formula
- C7H9NO
- Formula Weight
- 123.15
- MOL File
- 102074-19-1.mol
(5-METHYLPYRIDIN-3-YL)METHANOL Property
- Boiling point:
- 256℃
- Density
- 1.092
- Flash point:
- 109℃
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- 13.70±0.10(Predicted)
- form
- liquid
- color
- Light brown
Safety
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M337945
- Product name
- (5-Methylpyridin-3-yl)methanol
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- OR932347
- Product name
- (5-Methylpyridin-3-yl)methanol
- Purity
- 98%
- Packaging
- 1g
- Price
- $80
- Updated
- 2021/12/16
- Product number
- W9908
- Product name
- 5-Methyl-3-pyridinemethanol
- Packaging
- 1g
- Price
- $96
- Updated
- 2021/12/16
- Product number
- CS-0040539
- Product name
- 5-Methyl-3-pyridinemethanol
- Packaging
- 5g
- Price
- $130
- Updated
- 2021/12/16
- Product number
- OR932347
- Product name
- (5-Methylpyridin-3-yl)methanol
- Purity
- 98%
- Packaging
- 5g
- Price
- $185
- Updated
- 2021/12/16
(5-METHYLPYRIDIN-3-YL)METHANOL Chemical Properties,Usage,Production
Synthesis
29681-45-6
102074-19-1
Preparation of 5-methyl-3-pyridinemethanol: mix magnesium chloride, potassium borohydride and tetrahydrofuran according to the molar ratio of 2:2:1, raise the temperature to 67°C, reflux for 2 h, and then cool to room temperature to obtain solution B. Dissolve methyl 5-methylnicotinate prepared in step S1 in tetrahydrofuran, adjust the temperature to 40°C, and slowly dropwise add the solution B, and control the dropwise addition time to be completed in 1.3 hours. After the dropwise addition was completed, the reaction was continued at 40 °C for 1 hour with continuous stirring during the period. Upon completion of the reaction, it was cooled to room temperature to obtain Solution C. Methanol was added to Solution C to quench the reaction, followed by raising the temperature to 40 °C and removing the tetrahydrofuran and methanol by rotary evaporation to obtain Concentrate D. To Concentrate D, water was added and the extract was carried out with ethyl acetate for a total of three extractions. The ethyl acetate phases were combined and dried by adding anhydrous sodium sulfate to a moisture content of 0.3 wt%, filtered, and the ethyl acetate phase was taken for rotary evaporation to give the final 5-methyl-3-pyridine methanol.
References
[1] Journal of Medicinal Chemistry, 2004, vol. 47, # 25, p. 6299 - 6310
[2] Synthetic Communications, 2008, vol. 38, # 1, p. 122 - 127
[3] Patent: WO2012/97196, 2012, A1. Location in patent: Page/Page column 34
[4] Patent: EP2824103, 2015, A1. Location in patent: Paragraph 0040
[5] Patent: CN106560471, 2017, A. Location in patent: Paragraph 0055; 0061; 0067; 0073; 0079; 0085; 0091; 0096
(5-METHYLPYRIDIN-3-YL)METHANOL Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from (5-METHYLPYRIDIN-3-YL)METHANOL manufacturers
- Product
- (5-METHYLPYRIDIN-3-YL)METHANOL 102074-19-1
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-10-28
- Product
- (5-METHYLPYRIDIN-3-YL)METHANOL 102074-19-1
- Price
- US $20.00-1.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 20 tons
- Release date
- 2023-09-15
- Product
- (5-METHYLPYRIDIN-3-YL)METHANOL 102074-19-1
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 989
- Supply Ability
- 200kg
- Release date
- 2019-12-26