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(5-METHYLPYRIDIN-3-YL)METHANOL

Product Name
(5-METHYLPYRIDIN-3-YL)METHANOL
CAS No.
102074-19-1
Chemical Name
(5-METHYLPYRIDIN-3-YL)METHANOL
Synonyms
Fumarate Impurity 1;Rupatadine impurity 3;Fumarate R Impurity 1;Lupatadine Impurity 5;5-methy-3-pyridylmethanol;5-Methyl-3-pyridineMethano;Nicotine Related Compound 3;5-Methylpyridine-3-Methanol;3-methylpyridine-5-methanol;Piperidine,1-(3-butyn-4-yl)-
CBNumber
CB5353437
Molecular Formula
C7H9NO
Formula Weight
123.15
MOL File
102074-19-1.mol
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(5-METHYLPYRIDIN-3-YL)METHANOL Property

Boiling point:
256℃
Density 
1.092
Flash point:
109℃
storage temp. 
Inert atmosphere,Room Temperature
pka
13.70±0.10(Predicted)
form 
liquid
color 
Light brown
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Safety

Risk Statements 
36/37/38
Safety Statements 
26-36/37/39
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
M337945
Product name
(5-Methylpyridin-3-yl)methanol
Packaging
100mg
Price
$75
Updated
2021/12/16
Apolloscientific
Product number
OR932347
Product name
(5-Methylpyridin-3-yl)methanol
Purity
98%
Packaging
1g
Price
$80
Updated
2021/12/16
AK Scientific
Product number
W9908
Product name
5-Methyl-3-pyridinemethanol
Packaging
1g
Price
$96
Updated
2021/12/16
ChemScene
Product number
CS-0040539
Product name
5-Methyl-3-pyridinemethanol
Packaging
5g
Price
$130
Updated
2021/12/16
SynQuest Laboratories
Product number
4H56-1-769
Product name
(5-Methylpyridin-3-yl)methanol
Purity
97.0%
Packaging
250mg
Price
$220
Updated
2021/12/16
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(5-METHYLPYRIDIN-3-YL)METHANOL Chemical Properties,Usage,Production

Synthesis

29681-45-6

102074-19-1

Preparation of 5-methyl-3-pyridinemethanol: mix magnesium chloride, potassium borohydride and tetrahydrofuran according to the molar ratio of 2:2:1, raise the temperature to 67°C, reflux for 2 h, and then cool to room temperature to obtain solution B. Dissolve methyl 5-methylnicotinate prepared in step S1 in tetrahydrofuran, adjust the temperature to 40°C, and slowly dropwise add the solution B, and control the dropwise addition time to be completed in 1.3 hours. After the dropwise addition was completed, the reaction was continued at 40 °C for 1 hour with continuous stirring during the period. Upon completion of the reaction, it was cooled to room temperature to obtain Solution C. Methanol was added to Solution C to quench the reaction, followed by raising the temperature to 40 °C and removing the tetrahydrofuran and methanol by rotary evaporation to obtain Concentrate D. To Concentrate D, water was added and the extract was carried out with ethyl acetate for a total of three extractions. The ethyl acetate phases were combined and dried by adding anhydrous sodium sulfate to a moisture content of 0.3 wt%, filtered, and the ethyl acetate phase was taken for rotary evaporation to give the final 5-methyl-3-pyridine methanol.

References

[1] Journal of Medicinal Chemistry, 2004, vol. 47, # 25, p. 6299 - 6310
[2] Synthetic Communications, 2008, vol. 38, # 1, p. 122 - 127
[3] Patent: WO2012/97196, 2012, A1. Location in patent: Page/Page column 34
[4] Patent: EP2824103, 2015, A1. Location in patent: Paragraph 0040
[5] Patent: CN106560471, 2017, A. Location in patent: Paragraph 0055; 0061; 0067; 0073; 0079; 0085; 0091; 0096

(5-METHYLPYRIDIN-3-YL)METHANOL Preparation Products And Raw materials

Raw materials

Preparation Products

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(5-METHYLPYRIDIN-3-YL)METHANOL Suppliers

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View Lastest Price from (5-METHYLPYRIDIN-3-YL)METHANOL manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
(5-METHYLPYRIDIN-3-YL)METHANOL 102074-19-1
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-28
Hebei Yanxi Chemical Co., Ltd.
Product
(5-METHYLPYRIDIN-3-YL)METHANOL 102074-19-1
Price
US $20.00-1.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20 tons
Release date
2023-09-15
Career Henan Chemical Co
Product
(5-METHYLPYRIDIN-3-YL)METHANOL 102074-19-1
Price
US $1.00/g
Min. Order
1g
Purity
989
Supply Ability
200kg
Release date
2019-12-26

102074-19-1, (5-METHYLPYRIDIN-3-YL)METHANOLRelated Search:

DIETHYL 2,6-DIMETHYL-3,5-PYRIDINEDICARBOXYLATE Diethyl pyridine-3,5-dicarboxylate 5-ETHYLPYRIDINE-2,3-DICARBOXYLIC ACID 3-Pyridinemethanol DIMETHYL 4-(4-METHOXYPHENYL)-2,6-DIMETHYLPYRIDINE-3,5-DICARBOXYLATE 3,5-PYRIDINEDICARBOXYLIC ACID 2,6-DIMETHYL-3,5-PYRIDINEDICARBOXYLIC ACID 2-METHYL-10-OXO-10H-9-OXA-1-AZA-ANTHRACENE-3-CARBOXYLIC ACID METHYL ESTER 6-HYDROXY-5-(2-HYDROXYBENZOYL)-2-(TRIFLUOROMETHYL)NICOTINIC ACID 2-METHYL-5-OXO-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXYLIC ACID METHYL 2-(METHOXYMETHYL)-5-OXO-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXYLATE METHYL 2-ETHYL-7-METHYL-5-OXO-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXYLATE ETHYL 5-CYANO-6-(METHYLSULFANYL)-2-PHENYLNICOTINATE ETHYL 2-[2-(3,5-DICHLOROANILINO)VINYL]-5-OXO-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXYLATE ETHYL 2-(2-ANILINOVINYL)-5-OXO-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXYLATE METHYL 5-CYANO-2-(DIMETHOXYMETHYL)-6-MERCAPTONICOTINATE 5-ACETYL-6-HYDROXY-2-METHYL-NICOTINIC ACID ETHYL ESTER ETHYL 5-OXO-2-[2-(3-PYRIDINYLAMINO)VINYL]-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXYLATE

  • (5-METHYLPYRIDIN-3-YL)METHANOL
  • 3-Pyridinemethanol,5-methyl-(6CI,9CI)
  • 3-Hydroxymethyl-5-methylpyridine
  • 5-Methyl-3-pyridineMethano
  • 3-PyridineMethanol,5-Methyl-
  • 5-methy-3-pyridylmethanol
  • Fumarate R Impurity 1
  • Rupatadine impurity 3
  • Fumarate Impurity 1
  • Nicotine Related Compound 3
  • Piperidine,1-(3-butyn-4-yl)-
  • Lupatadine Impurity 5
  • (5-Methyl-3-pyridyl)methanol
  • 5-Methylpyridine-3-Methanol
  • (5-Methyl-3-pyridinyl)methanol
  • 3-methylpyridine-5-methanol
  • 102074-19-1
  • PYRIDINE