L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE
- Product Name
- L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE
- CAS No.
- 159190-45-1
- Chemical Name
- L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE
- Synonyms
- L-NIL HCL;L-NIL DIHYDROCHLORIDE;L-N6-(1-Iminoethyl)lysine;OQIBCXRAFAHXMM-KLXURFKVSA-N;L-N6-(1-IMINOETHYL)-LYSINE 2HCL;L-N6-(1-IMINOETHYL)LYSINE, DIHCL;L-Lysine ω-acetamidine dihydrochloride;L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE;LNIL dihydrochloride,L NIL dihydrochloride;N6-(1-IMINOETHYL)-L-LYSINE DIHYDROCHLORIDE
- CBNumber
- CB5353543
- Molecular Formula
- C8H18ClN3O2
- Formula Weight
- 223.7
- MOL File
- 159190-45-1.mol
L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE Property
- storage temp.
- -20°C
- solubility
- DMF: 15 mg/mL; DMSO: 15 mg/mL; Ethanol: 1 mg/mL; PBS: 30 mg/mL; Water: 50 mg/ml
- form
- White to off-white solid.
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 37/39-26-36
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- I8021
- Product name
- L-N6-(1-Iminoethyl)lysine dihydrochloride
- Packaging
- 10mg
- Price
- $132
- Updated
- 2024/03/01
- Product number
- 80310
- Product name
- L-NIL (hydrochloride)
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $40
- Updated
- 2024/03/01
- Product number
- 80310
- Product name
- L-NIL (hydrochloride)
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $9
- Updated
- 2021/12/16
- Product number
- 80310
- Product name
- L-NIL (hydrochloride)
- Purity
- ≥95%
- Packaging
- 50mg
- Price
- $148
- Updated
- 2024/03/01
- Product number
- 80310
- Product name
- L-NIL (hydrochloride)
- Purity
- ≥95%
- Packaging
- 100mg
- Price
- $276
- Updated
- 2024/03/01
L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE Chemical Properties,Usage,Production
Description
L-NIL is a relatively selective inhibitor of iNOS. It exhibits IC50 values of 0.4-3.3 μM for iNOS as opposed to 8-38 and 17-92 μM for eNOS and nNOS, respectively. L-NIL effectively inhibits iNOS both in vitro and in vivo. L-NIL has been used to demonstrate a critical role for iNOS in the immune response to infection by the protozoan L. major.
Uses
L-N6-(1-Iminoethyl)lysine dihydrochloride has been used as an inducible nitric oxide synthase (iNOS) inhibitor:
- to study its effects on leptin-induced modulation of fibronectin type III domain-containing five (FNDC5)/irisin in myocytes and fat cells of murine
- to study its effects on leptin-induced inflammation in hepatocytes
- to block the production of nitric oxide in mice bone marrow mesenchymal stromal cells (BMSCs)
Definition
ChEBI: N(6)-acetimidoyl-L-lysine dihydrochloride is a hydrochloride salt prepared from N(6)-acetimidoyl-L-lysine and two equivalents of hydrogen chloride. A selective inhibitor of inducible nitric oxide synthase. It has a role as an EC 1.14.13.39 (nitric oxide synthase) inhibitor. It contains a N(6)-acetimidoyl-L-lysinium(2+).
Biochem/physiol Actions
Selective inhibitor of inducible nitric oxide synthase (iNOS).