2-(4-CHLOROPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
- Product Name
- 2-(4-CHLOROPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
- CAS No.
- 769944-39-0
- Chemical Name
- 2-(4-CHLOROPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
- Synonyms
- 1-Boc-2-(4-chlorophenyl)piperazine;t-Butyl 2-(4-chlorophenyl)piperazine-1-carboxylate;tert-Butyl 2-(4-chlorophenyl)piperazine-1-carboxylate;2-(4-CHLOROPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;2-(4-chlorophenyl)-1-piperazinecarboxylic acid tert-butyl ester;1-Piperazinecarboxylic acid, 2-(4-chlorophenyl)-, 1,1-dimethylethyl ester
- CBNumber
- CB5354520
- Molecular Formula
- C15H21ClN2O2
- Formula Weight
- 296.79
- MOL File
- 769944-39-0.mol
2-(4-CHLOROPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Property
- storage temp.
- 2-8°C
- InChI
- InChI=1S/C15H21ClN2O2/c1-15(2,3)20-14(19)18-9-8-17-10-13(18)11-4-6-12(16)7-5-11/h4-7,13,17H,8-10H2,1-3H3
- InChIKey
- BYPYEMNCKKTEFT-UHFFFAOYSA-N
- SMILES
- N1(C(OC(C)(C)C)=O)CCNCC1C1=CC=C(Cl)C=C1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C350670
- Product name
- 2-(4-Chlorophenyl)piperazine-1-carboxylicAcidtert-ButylEster
- Packaging
- 10mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- C350670
- Product name
- 2-(4-Chlorophenyl)piperazine-1-carboxylicAcidtert-ButylEster
- Packaging
- 25mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- W8368
- Product name
- 1-Boc-2-(4-Chlorophenyl)piperazine
- Packaging
- 100mg
- Price
- $135
- Updated
- 2021/12/16
- Product number
- W8368
- Product name
- 1-Boc-2-(4-Chlorophenyl)piperazine
- Packaging
- 250mg
- Price
- $186
- Updated
- 2021/12/16
- Product number
- COR0001507
- Product name
- 2-(4-CHLOROPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
- Purity
- 95.00%
- Packaging
- 250MG
- Price
- $302.4
- Updated
- 2021/12/16
2-(4-CHLOROPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Chemical Properties,Usage,Production
Synthesis
769944-38-9
769944-39-0
General procedure for the synthesis of tert-butyl 2-(4-chlorophenyl)piperazine-1-carboxylate from the compound (CAS: 769944-38-9): a solution of 4-(tert-butoxycarbonyl)-3-(4-chlorophenyl)piperazin-2-one (500 mg, 1.6 mmol) and acetic acid (929 μL, 16 mmol) was added to refluxing 1,4-dioxane (5 mL ), followed by sodium borohydride (608 mg, 16 mmol). The reflux reaction was continued. Upon completion of the reaction, the reaction was quenched with water, the organic phase was extracted with dichloromethane and washed with brine and the organic phase was dried. After removing the solvent under reduced pressure, the residue was purified by silica gel column chromatography to afford 4-(tert-butoxycarbonyl)-3-(4-chlorophenyl)piperazine (330 mg, 69% yield).1H-NMR (CDCl3) δ 1.46 (9H, s), 2.76-2.99 (3H, m), 3.13 (1H, dd, J = 13.0 Hz, 4.3 Hz), 3.45-3.49 (3H, m). 3.45-3.49 (2H, m), 3.92 (1H, m), 5.15 (1H, s), 7.27-7.33 (4H, m).
References
[1] Patent: WO2004/85408, 2004, A1. Location in patent: Page 264
[2] Bioorganic and Medicinal Chemistry Letters, 2017, vol. 27, # 16, p. 3726 - 3732
2-(4-CHLOROPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
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