ChemicalBook > CAS DataBase List > 2-(Bromomethyl)-5-(trifluoromethyl)furan
2-(Bromomethyl)-5-(trifluoromethyl)furan
- Product Name
- 2-(Bromomethyl)-5-(trifluoromethyl)furan
- CAS No.
- 17515-77-4
- Chemical Name
- 2-(Bromomethyl)-5-(trifluoromethyl)furan
- Synonyms
- 2-(BROMOMETHYL)-5-(TRIFLUOROMETHYL)FURAN;2-(Bromomethyl)-5-(trifluoromethyl)furane;Furan,2-(broMoMethyl)-5-(trifluoroMethyl)-;2-(Bromomethyl)-5-(trifluoromethyl)furan97%;2-(Bromomethyl)-5-(trifluoromethyl)furan 97%
- CBNumber
- CB5355572
- Molecular Formula
- C6H4BrF3O
- Formula Weight
- 228.99
- MOL File
- 17515-77-4.mol
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2-(Bromomethyl)-5-(trifluoromethyl)furan Property
- Boiling point:
- 38 °C
- Density
- 1.693±0.06 g/cm3(Predicted)
- refractive index
- 1.45
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- Chloroform (Slightly), Ethyl Acetate (Slightly)
- form
- Oil
- color
- Clear Colourless
- InChI
- InChI=1S/C6H4BrF3O/c7-3-4-1-2-5(11-4)6(8,9)10/h1-2H,3H2
- InChIKey
- YNHVBNGRNNVEMD-UHFFFAOYSA-N
- SMILES
- O1C(C(F)(F)F)=CC=C1CBr
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Safety
- Hazard Codes
- C
- Risk Statements
- 34-36/37/38-43
- Safety Statements
- 26-36/37/39-45-36/37
- RIDADR
- 1760
- Hazard Note
- Corrosive
- HazardClass
- 8
- PackingGroup
- Ⅲ
- HS Code
- 2932190090
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
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N-Bromosuccinimide Price
TCI Chemical
- Product number
- B5800
- Product name
- 2-(Bromomethyl)-5-(trifluoromethyl)furan
- Purity
- >97.0%(GC)
- Packaging
- 200mg
- Price
- $39
- Updated
- 2025/07/31
TCI Chemical
- Product number
- B5800
- Product name
- 2-(Bromomethyl)-5-(trifluoromethyl)furan
- Purity
- >97.0%(GC)
- Packaging
- 1g
- Price
- $156
- Updated
- 2025/07/31
TRC
- Product number
- B687925
- Product name
- 2-(Bromomethyl)-5-(trifluoromethyl)furan
- Packaging
- 250mg
- Price
- $80
- Updated
- 2021/12/16
TRC
- Product number
- B687925
- Product name
- 2-(Bromomethyl)-5-(trifluoromethyl)furan
- Packaging
- 25g
- Price
- $895
- Updated
- 2021/12/16
SynQuest Laboratories
- Product number
- 2H07-B-X0
- Product name
- 2-(Bromomethyl)-5-(trifluoromethyl)furan
- Purity
- 95%
- Packaging
- 5G
- Price
- $152
- Updated
- 2021/12/16
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2-(Bromomethyl)-5-(trifluoromethyl)furan Chemical Properties,Usage,Production
Uses
2-(Bromomethyl)-5-(trifluoromethyl)furan is an intermediate used to prepare tertiary sulfonamides as liver X receptor antagonists. It is also used to synthesize hydantoin based inhibitors of MMP13 with potential use in osteoarthritis.
Synthesis
17515-75-2
17515-77-4
The general procedure for the synthesis of 2-bromomethyl-5-trifluoromethylfuran from 5-methyl-2-trifluoromethylfuran was as follows: to a solution of 2-methyl-5-(trifluoromethyl)furan (4 g, 26.6 mmol) in chloroform (60 mL) was added sequentially N-bromosuccinimide (5.2 g, 29.3 mmol) and 2,2'-azobis(isobutyronitrile) (220 mg 1.33 mmol). The reaction mixture was heated to reflux for 15 minutes. After completion of the reaction, the reaction solution was cooled, poured into water (200 mL) and extracted with chloroform. The organic phases were combined, washed sequentially with water and saturated saline and dried over anhydrous magnesium sulfate. The solvent was concentrated under reduced pressure to give 2-(bromomethyl)-5-(trifluoromethyl)furan (4.79 g, 78% yield). Infrared spectrum of the product (KBr pressed sheet) νmax/cm-1 : 1738, 1688, 1599, 1559. 1H-NMR (CDCl3) δ: 4.46 (2H, s), 6.45 (1H, d, J = 3.8 Hz), 6.75 (1H, d, J = 3.8 Hz).
References
[1] Patent: EP1362846, 2003, A1. Location in patent: Page/Page column 125
2-(Bromomethyl)-5-(trifluoromethyl)furan Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-(Bromomethyl)-5-(trifluoromethyl)furan manufacturers
Henan Aochuang Chemical Co.,Ltd.
- Product
- 2-(Bromomethyl)-5-(trifluoromethyl)furan 17515-77-4
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-14
Career Henan Chemical Co
- Product
- 2-(Bromomethyl)-5-(trifluoromethyl)furan 17515-77-4
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2018-08-15
Career Henan Chemical Co
- Product
- 2-(Bromomethyl)-5-(trifluoromethyl)furan 17515-77-4
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1000KG
- Release date
- 2018-08-15
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