Closantel

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Description References

Product Name: Closantel
CAS No.: 57808-65-8
Chemical Name: Closantel
Synonyms: Zycloz;Diantel;R-31520;Closante;CLOSANTEL;faskoverm;5-diiodo-y-;iodobenzamide;CLOSANTEL BASE;Cyanoliodamide
CBNumber: CB5360606
Molecular Formula: C22H14Cl2I2N2O2
Formula Weight: 663.07
MOL File: 57808-65-8.mol

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Closantel Property

Melting point:: 217.8°
Boiling point:: 590.5±50.0 °C(Predicted)
Density: 1.8759 (estimate)
storage temp.: Keep in dark place,Sealed in dry,2-8°C
solubility: DMF: 20 mg/ml; DMSO: 20 mg/ml; DMSO:PBS (pH 7.2)(1:5): 0.16 mg/ml
pka: 5.99±0.48(Predicted)
form: Solid
color: White to off-white
CAS DataBase Reference: 57808-65-8(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 22
RIDADR: 2811
WGK Germany: 3
RTECS: CV2444250
HazardClass: 6.1(b)
PackingGroup: III
Toxicity: A veterinary drug for the treatment of fluke and nematode infestations. In 1993, some was included in a batch of donated drugs sent to Lithuania. Attempts to match the product with the names of other medicines on accompanying literature resulted in its misidentification as a treatment for endometriosis. Eleven women lost their eyesight; though this has since returned, they were left with eye pain and are unable to work.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P273Avoid release to the environment.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 34093
Product name: Closantel
Purity: PESTANAL
Packaging: 100mg
Price: $117
Updated: 2024/03/01

Cayman Chemical

Product number: 20531
Product name: Closantel
Purity: ≥98%
Packaging: 50mg
Price: $57
Updated: 2024/03/01

Cayman Chemical

Product number: 20531
Product name: Closantel
Purity: ≥98%
Packaging: 100mg
Price: $89
Updated: 2024/03/01

Cayman Chemical

Product number: 20531
Product name: Closantel
Purity: ≥98%
Packaging: 500mg
Price: $330
Updated: 2024/03/01

Cayman Chemical

Product number: 20531
Product name: Closantel
Purity: ≥98%
Packaging: 1g
Price: $547
Updated: 2024/03/01

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Closantel Chemical Properties,Usage,Production

Description

Closantel is a kind of synthetic anti parasitic agent which is actively against liver fluke, bloodsucking nematodes and larval stages of some arthropods in sheep and cattle. Its mechanism of action is through decoupling the mitochondrial oxidative phosphorylation, thus inhibiting the production of ATP. Therefore, it inhibit their energy generation of the parasite, causing their death. It is mainly used for the treatment and prevention of several infections caused by many kinds of parasites such as Fasciola hepatica, Fasciola gigantica, Haemonchus concortus, Haemonchus placei, Bunostomum phlebotomum, Oesophagostomum radiatum and Strongyloides papillosus in cattle and sheep.

References

http://www.interchemie.com/veterinary-medicines/closan-50.html

Chemical Properties

White to light yellow powder

Uses

antianginal, antihypertensive

Definition

ChEBI: N-{5-chloro-4-[(4-chlorophenyl)(cyano)methyl]-2-methylphenyl}-2-hydroxy-3,5-diiodobenzamide is an aromatic amide resulting from the formal condensation of the carboxy group of 3,5-diiodosalicylic acid with the amino group of aniline substituted at positions 2, 4, and 5 by methyl, (4-chlorophenyl)(cyano)methyl, and methyl groups respectively. It is a nitrile, a member of phenols, an organoiodine compound, a monocarboxylic acid amide, an aromatic amide and a member of monochlorobenzenes.

Closantel Preparation Products And Raw materials

Raw materials

Preparation Products

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Closantel Suppliers

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View Lastest Price from Closantel manufacturers

Hebei Mujin Biotechnology Co.,Ltd

Product: Closantel 57808-65-8
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2023-06-27

Asia Chem I and E (Jiangsu) Co Ltd

Product: Closantel 57808-65-8
Price: US $300.00/kg
Min. Order: 1kg
Purity: 99.0%min
Supply Ability: 3tons/momth
Release date: 2024-12-30

Hebei Weibang Biotechnology Co., Ltd

Product: Closantel 57808-65-8
Price: US $10.00/KG
Min. Order: 100KG
Purity: 99%
Supply Ability: 100 mt
Release date: 2024-11-26

57808-65-8, ClosantelRelated Search:

CHLOROPHOSPHONAZO III Cyhalothrin Cyhalothrin Niclosamide ethanolamine salt Niclosamide theta-Cypermethrin BETA-CYPERMETHRIN Oxyclozanide 2-(4-Amino-2-chloro-5-methylphenyl)-2-(4-chlorophenyl)acetonitrile 2-HYDROXY-5-IODO-BENZALDEHYDE 2-(2-Chlorophenyl)acetonitrile 3-Methylbenzyl cyanide 3,5-DIIODOSALICYLALDEHYDE Difluorochloromethane 3-Iodobenzylamine hydrochloride (4-AMINOPHENYL)PHENYLACETONITRILE HYDROCHLORIDE,97% 2-(4-aminophenyl)propiononitrile closantel sodium salt,CLOSANTEL SODIUM,CLOSANTEL(NA)

5-diiodo-y-

benzamide,n-(5-chloro-4-((4-chlorophenyl)cyanomethyl)-2-methylphenyl)-2-hydrox

faskoverm

CLOSANTEL

CLOSANTEL BASE

N-[5-CHLORO-4-(4-CHLORO-ALPHA-CYANOBENZYL)-2-METHYLPHENYL]-2-HYDROXY-3,5-DIIODOBENZAMIDE

n-[5-chloro-4-[(chlorophenyl)cyannomethyl]-2-methylphenyl]-2-hydroxy-3,5-diiodobenzamid

iodobenzamide

n-(5-chloro-4-((4-chlorophenyl)cyanomethyl)-2-methylphenyl)-2-hydroxy-3,5-di

5'-CHLORO-4'-(4-CHLORO-ALPHA-CYANOBENZYL)-3,5-DIIODO-2'-METHYLSALICYLANILIDE

N-[5-CHLORO-4(4-CHLOROPHENYL)CYANOMETHYL]-2-METHYLPHENYL]-2-HYDROXYL-3,5-DIIODO BENZAMIDE

Benzamide, N-5-chloro-4-(4-chlorophenyl)cyanomethyl-2-methylphenyl-2-hydroxy-3,5-diiodo-

5'-chloro-4'-(4-chloro-α-cyanobenzyl)-3,5-diiodo-2'-methylsalicylanilide

CLOSANTEL(PATENT)

N-[5-CHLORO-4(4-CHLOROPHENYL)CYANOMETHYL]-2-METHYLPHENYL]-2-HYDROXYL-3,5-DIIODOBENZAMIDE(CLOSANTEL)

N-[5-Chloro-4-[(chlorophenyl)cyannomethyl]-2-methylphenyl]-2-hydroxy-3,5-diiodobenzamide

N-[5-Chloro-4-(4-chloro-α-cyanobenzyl)-2-methylphenyl]-2-hydroxy-3,5-diiodobenzamide, 5μ-Chloro-4μ-(4-chloro-α-cyanobenzyl)-3,5-diiodo-2μ-methylsalicylanilide

Diantel

N-(5-Chloro-4-((4-chlorophenyl)cyanomethyl)-2-methylphenyl)-2-hydroxy-3,5-diiodobenzamide

R-31520

Zycloz

5'-Chloro-.alpha.4-(p-chlorophenyl)-.alpha.4-cyano-3,5-diiodo-2',4'-salicyloxylidide

Benzamide, N-[5-chloro-4-[(4-chlorophenyl)cyanomethyl]-2-methylphenyl]-2-hy

Closantelfreebase

N-(5-Chloro-4-[(RS)-(4-chlorophenyl)cyanomethyl]-2-methylphenyl)-2-hydroxy-3,5-diiodobenzamide

Closante

Closantel Solution in Methanol/DMSO, 1000ug/mL

Cyanoliodamide

Closantel N-[5-chloor-4-[(4-chloorfenyl)-cyanomethyl]-2-methylfenyl]-2- hydroxy-3,5-di-joodbenzamide

Closantel in Methanol:DMSO=2:1

Closantel 100 μg/ml Acetonitrile

C11691500 Closantel

Chlorocyanine iodosamide

Closantel, 10 mM in DMSO

57808-65-8

57805-65-8

C22H14Cl2I2N2O2

COREG CR