ChemicalBook > CAS DataBase List > 3-BROMO-4-(TRIFLUOROMETHOXY)BENZALDEHYDE

3-BROMO-4-(TRIFLUOROMETHOXY)BENZALDEHYDE

Product Name
3-BROMO-4-(TRIFLUOROMETHOXY)BENZALDEHYDE
CAS No.
85366-66-1
Chemical Name
3-BROMO-4-(TRIFLUOROMETHOXY)BENZALDEHYDE
Synonyms
3-BROMO-4-(TRIFLUOROMETHOXY)BENZALDEHYDE;Benzaldehyde, 3-bromo-4-(trifluoromethoxy)-;3-Bromo-4-(trifluoromethoxy)benzaldehyde98%;2-Bromo-4-formyl-alpha,alpha,alpha-trifluoroanisole
CBNumber
CB5361906
Molecular Formula
C8H4BrF3O2
Formula Weight
269.02
MOL File
85366-66-1.mol
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3-BROMO-4-(TRIFLUOROMETHOXY)BENZALDEHYDE Property

storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
form 
liquid
color 
clear, faint yellow
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Safety

Hazard Codes 
Xi
Hazard Note 
Irritant
HS Code 
2913000090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC
Product number
B678628
Product name
3-Bromo-4-(trifluoromethoxy)benzaldehyde
Packaging
50mg
Price
$45
Updated
2021/12/16
TRC
Product number
B678628
Product name
3-Bromo-4-(trifluoromethoxy)benzaldehyde
Packaging
500mg
Price
$90
Updated
2021/12/16
TRC
Product number
B678628
Product name
3-Bromo-4-(trifluoromethoxy)benzaldehyde
Packaging
100mg
Price
$60
Updated
2021/12/16
SynQuest Laboratories
Product number
2615-B-X2
Product name
3-Bromo-4-(trifluoromethoxy)benzaldehyde
Purity
99%
Packaging
1g
Price
$61
Updated
2021/12/16
Apolloscientific
Product number
PC1105
Product name
3-Bromo-4-(trifluoromethoxy)benzaldehyde
Purity
97%
Packaging
1g
Price
$56
Updated
2021/12/16
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3-BROMO-4-(TRIFLUOROMETHOXY)BENZALDEHYDE Chemical Properties,Usage,Production

Synthesis

659-28-9

85366-66-1

The general procedure for the synthesis of 3-bromo-4-(trifluoromethoxy)benzaldehyde from 4-trifluoromethoxybenzaldehyde was as follows: 68 g (0.36 mol) of 4-trifluoromethoxybenzaldehyde was dissolved in a mixture of 100 ml of dichloromethane, 100 ml of trifluoroacetic acid and 50 ml of concentrated sulfuric acid. The reaction mixture was stirred at room temperature and 130 g (0.72 mol) of N-bromosuccinimide was slowly added over 7 hours. After the addition was completed, the reaction mixture continued to be stirred at room temperature for 2 days. At the end of the reaction, the reaction mixture was poured into 1.2 liters of ice-water mixture. The aqueous phase was extracted three times with 500 ml of dichloromethane, the organic phases were combined and neutralized with 500 ml of saturated sodium bicarbonate solution. Subsequently, the organic phase was dried with anhydrous sodium sulfate. After filtration to remove the desiccant, the organic solvent was removed by rotary evaporator under reduced pressure. To the residue, 500 ml of mixed n-pentane/ether (1:1) solvent was added and the precipitated succinimide was removed by filtration. The organic solvent was again removed by distillation under reduced pressure and the residue was purified by silica gel column chromatography (250 g, particle size 0.04-0.063 mm, Merck) using ethyl acetate/n-heptane (1:4) as mobile phase. Finally, 14 g of the target product was obtained. The product structure was confirmed by 1H-NMR (d6-DMSO, 600 MHz, δ ppm): 7.77 (d, J = 8.1 Hz, 1H), 8.05 (dd, J = 8.1 Hz, 1.7 Hz, 1H), 8.34 (d, J = 1.7 Hz, 1H), 10.01 (br s, 1H).

References

[1] Patent: US2003/144329, 2003, A1
[2] Patent: US2003/83357, 2003, A1
[3] Patent: US2003/105333, 2003, A1
[4] Patent: US6515003, 2003, B1
[5] Patent: WO2013/92756, 2013, A1. Location in patent: Page/Page column 52; 53

3-BROMO-4-(TRIFLUOROMETHOXY)BENZALDEHYDE Preparation Products And Raw materials

Raw materials

Preparation Products

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3-BROMO-4-(TRIFLUOROMETHOXY)BENZALDEHYDE Suppliers

China 47 India 1 Italy 1 United Kingdom 1 United States 4 Global 54
Ricci Chimica
Tel
--
Fax
--
Email
sales@riccichimica.com
Country
Italy
ProdList
2146
Advantage
46
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View Lastest Price from 3-BROMO-4-(TRIFLUOROMETHOXY)BENZALDEHYDE manufacturers

Career Henan Chemical Co
Product
3-BROMO-4-(TRIFLUOROMETHOXY)BENZALDEHYDE 85366-66-1
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200kgs
Release date
2020-02-17

85366-66-1, 3-BROMO-4-(TRIFLUOROMETHOXY)BENZALDEHYDERelated Search:

4-(Trifluoromethoxy)benzaldehyde

  • 3-BROMO-4-(TRIFLUOROMETHOXY)BENZALDEHYDE
  • 2-Bromo-4-formyl-alpha,alpha,alpha-trifluoroanisole
  • 3-Bromo-4-(trifluoromethoxy)benzaldehyde98%
  • Benzaldehyde, 3-bromo-4-(trifluoromethoxy)-
  • 85366-66-1