ANISOMYCIN
- Product Name
- ANISOMYCIN
- CAS No.
- 22862-76-6
- Chemical Name
- ANISOMYCIN
- Synonyms
- Nsc76712;Nsc147340;Aids031977;ANISOMYCIN;FLAGECIDIN;Aids-031977;Wuningmeisu C;4-beta))-alph;Anisomycin>(-)-anisomycin
- CBNumber
- CB5363672
- Molecular Formula
- C14H19NO4
- Formula Weight
- 265.3
- MOL File
- 22862-76-6.mol
ANISOMYCIN Property
- Melting point:
- 140-141 C
- alpha
- D23 -30° (methanol)
- Boiling point:
- 408.52°C (rough estimate)
- Density
- 1.1356 (rough estimate)
- refractive index
- 1.5230 (estimate)
- Flash point:
- 87℃
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- solubility
- methanol: 20 mg/mL, clear, colorless to faintly yellow
- form
- solid
- pka
- 7.9(at 25℃)
- color
- white
- Water Solubility
- Soluble in water at 2 mg/ml, in DMSO at 20mg/ml, and in methanol at 20mg/ml
- λmax
- 283nm(EtOH)(lit.)
- Merck
- 14,670
- BRN
- 20705
- Stability:
- Stable. Incompatible with strong oxidizing agents.
- InChIKey
- YKJYKKNCCRKFSL-RDBSUJKOSA-N
Safety
- Hazard Codes
- T,Xn
- Risk Statements
- 25-36/37/38-20/21/22
- Safety Statements
- 45-36-26
- RIDADR
- UN 3462 6.1/PG 3
- WGK Germany
- 3
- RTECS
- BZ9800000
- F
- 3-10
- HazardClass
- 6.1(b)
- PackingGroup
- III
- HS Code
- 29419090
- Toxicity
- LD50 orl-rat: 72 mg/kg ANTCAO 5,490,55
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- A9789
- Product name
- Anisomycin from Streptomyces griseolus
- Purity
- ≥98% (HPLC), solid
- Packaging
- 5mg
- Price
- $56.3
- Updated
- 2024/03/01
- Product number
- A5862
- Product name
- Anisomycin, Ready Made Solution from Streptomyces griseolus
- Packaging
- 0.5ml
- Price
- $85.9
- Updated
- 2024/03/01
- Product number
- A2613
- Product name
- Anisomycin
- Purity
- >97.0%(GC)
- Packaging
- 25mg
- Price
- $149
- Updated
- 2024/03/01
- Product number
- A2613
- Product name
- Anisomycin
- Purity
- >97.0%(GC)
- Packaging
- 100mg
- Price
- $437
- Updated
- 2024/03/01
- Product number
- J67498
- Product name
- Anisomycin, 10 mg/ml in DMSO, sterile-filtered
- Packaging
- 1ml
- Price
- $204.65
- Updated
- 2024/03/01
ANISOMYCIN Chemical Properties,Usage,Production
Description
Anisomycin (22862-76-6) activates JNK/SAPKs and reduces c-fos and c-jun. Protein synthesis inhibitor. Anisomycin induces apoptosis and sensitizes cells to anoikis. Cell permeable.
Chemical Properties
Crystalline
Uses
Anisomycin is a phenylmethylenepyrrolidine first isolated from Streptomyces griseolus in 1954 as an antiprotozoan with antifungal activity. Anisomycin is an inhibitor of protein synthesis by binding to the 60S ribosomal subunit. Interestingly, anisomycin has found use for the induction of amnesia in animal models. More recently, anisomycin has been demonstrated to induce apoptosis, to be a selective signalling agonist, to activate mitogen-activated protein (MAP) kinases and to be immunomodulatory via its action on T cells.
Uses
It is applied as an antiparasitic agent and antineoplastic agent. It acts as a protein synthesis inhibitor (blocks translation), potent activator of stress-activated protein kinases (JNK/SAPK) and p38 MAP kinase. It also scts as a potent signaling agonist to selectively elicit homologous desensitization of immediate early gene induction (c-fos, fosB, c-jun, junB and junD). Activates mitogen-activated protein (MAP) kinases (JNK/SAPK and p38/RK).
Definition
ChEBI: An antibiotic isolated from various Streptomyces species. It interferes with protein and DNA synthesis by inhibiting peptidyl transferase or the 80S ribosome system.
Biological Activity
Protein synthesis inhibitor (blocks translation). Potent activator of stress-activated protein kinases (JNK/SAPK) and p38 MAP kinase. Acts as a potent signaling agonist to selectively elicit homologous desensitization of immediate early gene induction (c-fos, fosB, c-jun, junB and junD).
Biochem/physiol Actions
Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. Reported to induce apoptosis in a variety of cells including promyelocytic leukemia cells, Jurkat cells, ventricular myocytes, and colon adenocarcinoma cells. Initiates intracellular signals and immediate early gene induction. Selective signaling agonist. Potent Jun-NH2 terminal kinase (JNK) agonist. Activates mitogen-activated protein (MAP) kinases (JNK/SAPK and p38/RK). Antiprotozoal agent.
Safety Profile
Poison by ingestion,intraperitoneal, subcutaneous, and intravenous routes.When heated to decomposition it emits toxic fumes ofNOx.
storage
+4°C
References
1) Hazzalin?et al. (1998),?Anisomycin Selectively Desensitizes Signalling Components Involved in Stress Kinase Activation and fos and jun Induction; Mol. Cell. Bio.,?8?1844 2) Mawji?et al. (2007),?A Chemical Screen Identifies Anisomycin as an Anoikis Sensitizer That Functions by Decreasing FLIP Protein Synthesis; Cancer Res.,?67?8307
ANISOMYCIN Preparation Products And Raw materials
Raw materials
Preparation Products
ANISOMYCIN Suppliers
- Tel
- 320-37350700
- Fax
- +32 (0)37350701
- sales@tcieurope.eu
- Country
- Europe
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- 23671
- Advantage
- 75
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- Country
- Europe
- ProdList
- 1780
- Advantage
- 38
- Tel
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- Fax
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- export@ecochem.dk
- Country
- Europe
- ProdList
- 6371
- Advantage
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View Lastest Price from ANISOMYCIN manufacturers
- Product
- Anisomycin 22862-76-6
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 0.98
- Supply Ability
- 1000
- Release date
- 2024-05-29
- Product
- ANISOMYCIN 22862-76-6
- Price
- US $8000.00/KG
- Min. Order
- 100g
- Purity
- 99.99%
- Supply Ability
- 5ton/Month
- Release date
- 2021-11-26
- Product
- ANISOMYCIN 22862-76-6
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 95%-99%
- Supply Ability
- 100kg
- Release date
- 2018-12-24