ChemicalBook > CAS DataBase List > SLU-PP-332

SLU-PP-332

Product Name: SLU-PP-332
CAS No.: 303760-60-3
Chemical Name: SLU-PP-332
Synonyms: SLU-PP;SLU-PP-332;SLU-PP-332 5mg;Slu-pp-332 capsules 250mcg 100pcs;4-hydroxy-N'-(2-naphthylmethylene)benzohydrazide;4-Hydroxy-N'-(naphthalen-2-ylmethylene)benzohydrazide;4-hydroxy-N'-(2-naphthylmethylene)benzohydrazide,SLU-PP-332;4-hydroxy-N'-[(E)-naphthalen-2-ylmethylidene]benzohydrazide;Benzoic acid, 4-hydroxy-, 2-(2-naphthalenylmethylene)hydrazide;(E)-4-Hydroxy-N′(Naphthalen-2-Ylmethylene)Benzohydrazide, SLU-PP-332
CBNumber: CB53644574
Molecular Formula: C18H14N2O2
Formula Weight: 290.32
MOL File: 303760-60-3.mol

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SLU-PP-332 Property

Density: 1.20±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: 2mg/mL, clear (Warmed)
pka: 8.44±0.15(Predicted)
form: Solid
color: White to off-white
InChI: InChI=1S/C18H14N2O2/c21-17-9-7-15(8-10-17)18(22)20-19-12-13-5-6-14-3-1-2-4-16(14)11-13/h1-12,21H,(H,20,22)
InChIKey: RNZIMBFHRXYRLL-UHFFFAOYSA-N
SMILES: C(NN=CC1=CC=C2C(=C1)C=CC=C2)(=O)C1=CC=C(O)C=C1

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Aronis compounds

Product number: M01386
Product name: 4-hydroxy-N'-(2-naphthylmethylene)benzohydrazide
Packaging: 5mg
Price: $15
Updated: 2021/12/16

Aronis compounds

Product number: M01386
Product name: 4-hydroxy-N'-(2-naphthylmethylene)benzohydrazide
Packaging: 50mg
Price: $50
Updated: 2021/12/16

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SLU-PP-332 Chemical Properties,Usage,Production

Description

SLU-PP-332 is a synthetic estrogen receptor-related orphan receptor (ERR) agonist which activates an amplified aerobic exercise mode. SLU-PP-332 does not affect food intake, appetite, or exercise initiation. This agent improves a natural metabolic pathway that characteristically reacts to exercise, resulting in amplified energy expenditure and extra body fat metabolism. SLU-PP-332 enhances mitochondrial function and cellular respiration in skeletal muscle cell lines, increases the expression of an ERR target gene [pyruvate dehydrogenase kinase 4 (Pdk4)], and enhances mitochondrial respiration in C2C12 myocytes.

Uses

SLU-PP-332 is a pan-Estrogen Receptor/ERR agonist with EC50 values of 98, 230 and 430 nM for ERRα, ERRβ and ERRγ, respectively. SLUPP-332 enhances mitochondrial function and cellular respiration in skeletal muscle cell lines. SLU-PP-332 has the potential to study metabolic diseases as well as improve muscle function[1].

benefits

SLU-PP-332 improves a natural metabolic route, which typically happens in response to exercise; it amplifies energy expenditure and results in faster body fat metabolism. SLU-PP-332 enhances mitochondrial function and cellular respiration in skeletal muscle cell lines, increases the expression of an ERR target gene [pyruvate dehydrogenase kinase 4 (Pdk4)], and enhances mitochondrial respiration in C2C12 myocytes. The drug also increases oxidative fibres in skeletal muscle and improved exercise endurance in C57BL/6J mice. This drug works on a group of proteins throughout the body organs called ERRs that activate some of the most significant metabolic pathways in the body, including the cardiac cells and the brain tissue. The drug can potentially transform the future of fitness and can facilitate weight loss by stimulating the body’s muscles during exercise. The mechanism of action of SLU-PP-332 is to activate ERRs, leading to increased energy expenditure, fatty acid oxidation, and decreased fat mass accumulation.

in vivo

SLU-PP-332 (50 mg/kg, i.p., a single dose for 28 or 12 days) increases mitochondrial function and cellular respiration in a skeletal muscle cell line and induces an ERRα-specific acute aerobic exercise genetic program in mice^[1].
SLU-PP-332 (50 mg/kg, i.p., twice per day for 28 days or 12 days) induces fatty acid metabolism, reduces fat mass and improves glucose metabolism in diet-induced obesity mouse models^[3].

Animal Model:	8-10 male C57BL/6J mice^[1]
Dosage:	50 mg/kg
Administration:	i.p., a single dose for 28 or 12 days
Result:	Displayed a more oxidative muscle phenotype, increased the complex I (NDUFB8) and complex V (ATP5A) protein expression in the gastrocnemius muscle and cytochrome C, mitochondria content and oxidative type IIa muscle fibers lavels in mice.

Animal Model:	High fat diet-induced obesity mouse model^[3]
Dosage:	50 mg/kg
Administration:	i.p., twice per day for 28 days or 12 days
Result:	Did not alter brown adipose tissue mass, daily food intake and glucose metabolism, increased fatty acid oxidation (FAO) in normal in C57Bl/6 mice, but induced a progressive weight loss and decreased adipocytes size in high fat diet-induced obesity mouse models.

IC 50

ERRα: 98 nM (EC₅₀); ERRβ: 230 nM (EC₅₀); ERRγ: 430 nM (EC₅₀)

References

[1] Nasri, Hamid. “New hopes on ‘SLU-PP-332’ as an effective agent for weight loss with indirect kidney protection efficacy; a nephrology point of view.” Journal of Renal Endocrinology 26 7 (2024).

SLU-PP-332 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from SLU-PP-332 manufacturers

Shandong Hanjiang Chemical Co., Ltd

Product: SLU-PP-332 303760-60-3
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1T
Release date: 2025-11-11

Shanghai Yimeixin Technology Co., LTD

Product: SLU-PP-332 303760-60-3
Price: US $0.00/box
Min. Order: 1box
Purity: 0.99
Supply Ability: 10tons
Release date: 2025-09-26

Hebei Lutong Import and Export Co., Ltd

Product: SLU-PP-332 303760-60-3
Price: US $100.00/mg
Min. Order: 100mg
Purity: 99.99%
Supply Ability: 20t
Release date: 2025-09-23

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