1H-INDENE, 6-BROMO-
- Product Name
- 1H-INDENE, 6-BROMO-
- CAS No.
- 33065-61-1
- Chemical Name
- 1H-INDENE, 6-BROMO-
- Synonyms
- SKL643;6-Bromoindene;5-broMoindene;Bromo-1H-indene;6-BROMO-1H-INDENE;16-Bromo-1H-indene;1H-INDENE, 6-BROMO-
- CBNumber
- CB5372885
- Molecular Formula
- C9H7Br
- Formula Weight
- 195.06
- MOL File
- 33065-61-1.mol
1H-INDENE, 6-BROMO- Property
- Boiling point:
- 245℃
- Density
- 1.523
- Flash point:
- 106℃
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- Light yellow to yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B336418
- Product name
- 6-bromo-1H-indene
- Packaging
- 500mg
- Price
- $310
- Updated
- 2021/12/16
- Product number
- HCH0354886
- Product name
- 6-BROMO-1H-INDENE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $504.1
- Updated
- 2021/12/16
- Product number
- CM192718
- Product name
- 6-Bromo-1H-indene
- Purity
- 95+%
- Packaging
- 10g
- Price
- $737
- Updated
- 2021/12/16
- Product number
- CD12082956
- Product name
- 6-Bromo-1H-indene
- Purity
- 97%
- Packaging
- 10g
- Price
- $780
- Updated
- 2021/12/16
- Product number
- CM192718
- Product name
- 6-Bromo-1H-indene
- Purity
- 95+%
- Packaging
- 25g
- Price
- $1388
- Updated
- 2021/12/16
1H-INDENE, 6-BROMO- Chemical Properties,Usage,Production
Synthesis
34598-49-7
33065-61-1
General procedure for the synthesis of 6-bromo-1H-indene from 5-bromoindanone: Sodium borohydride (1.1 g, 0.029 mol) was added in three batches to a solution of 5-bromoindan-1-one (3.09 g, 0.0136 mol; CAS No. 34598-49-7) in methanol (25 mL) under argon protection at a reaction temperature of 0 °C. After 2 hours of reaction, the reaction mixture was partitioned between ethyl acetate and water. The organic layer was separated, washed sequentially with water and brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give an amber solid (3.16 g). The solid (1.58 g) was dissolved in ethylene glycol (63 mL) and 20% by volume of aqueous sulfuric acid (63 mL) was added. The reaction mixture was heated to 75 °C, kept for 2 h, then cooled to room temperature and extracted with dichloromethane (2 times). The organic layers were combined, washed with saturated aqueous sodium bicarbonate, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography using hexane as eluent to afford the target product 6-bromo-1H-indene (0.76 g, 52% yield) as a clear liquid.
References
[1] Patent: WO2009/67202, 2009, A1. Location in patent: Page/Page column 195
[2] European Journal of Medicinal Chemistry, 2017, vol. 141, p. 101 - 112
[3] Organic and Biomolecular Chemistry, 2003, vol. 1, # 8, p. 1298 - 1307
[4] Bioorganic and Medicinal Chemistry Letters, 2002, vol. 12, # 5, p. 827 - 832
[5] Bioorganic and Medicinal Chemistry Letters, 1999, vol. 9, # 12, p. 1657 - 1662
1H-INDENE, 6-BROMO- Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1H-INDENE, 6-BROMO- manufacturers
- Product
- 1H-INDENE, 6-BROMO- 33065-61-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2019-12-19