ISOPULEGOL
- Product Name
- ISOPULEGOL
- CAS No.
- 89-79-2
- Chemical Name
- ISOPULEGOL
- Synonyms
- DL-ISOPULEGOL;(-)-ISOPULEGOL;(?)-Isopulegol;L-ISOPULEGOL;FEMA 2962;ISOPULEGOL;ISOPULEGOL, (-)-;ISOPULEGOL 99+%;P-MENTH-8-EN-3-OL;(-)-Isopulegol 99%
- CBNumber
- CB5383663
- Molecular Formula
- C10H18O
- Formula Weight
- 154.25
- MOL File
- 89-79-2.mol
ISOPULEGOL Property
- Melting point:
- 78°C
- Boiling point:
- 212 °C(lit.)
- Density
- 0.912 g/mL at 25 °C(lit.)
- vapor pressure
- 13.97Pa at 20℃
- FEMA
- 2962 | ISOPULEGOL
- refractive index
- n20/D 1.471(lit.)
- Flash point:
- 195 °F
- storage temp.
- -20°C
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- pka
- 15.11±0.60(Predicted)
- color
- Colourless
- Odor
- at 10.00 % in dipropylene glycol. minty cooling medicinal woody
- Odor Type
- minty
- optical activity
- [α]20/D 22°, neat
- Water Solubility
- 3g/L at 21.9℃
- JECFA Number
- 755
- BRN
- 1906573
- Stability:
- Light sensitive
- InChIKey
- ZYTMANIQRDEHIO-KXUCPTDWSA-N
- LogP
- 2.4 at 23℃
- CAS DataBase Reference
- 89-79-2(CAS DataBase Reference)
- EPA Substance Registry System
- Isopulegol (89-79-2)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-36/37/38
- Safety Statements
- 26-36/37/39
- RIDADR
- NA 1993 / PGIII
- WGK Germany
- 2
- F
- 10-23
- Toxicity
- The acute oral LD50 in rats was reported as 1.03 ± 0.10 ml/kg and the acute dermal LD50 in rabbits as approximately 3 ml/kg
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CRM40757
- Product name
- Isopulegol solution
- Purity
- certified reference material, 2000?μg/mL in methanol, ampule of 1?mL
- Packaging
- 1mL
- Price
- $117
- Updated
- 2024/03/01
- Product number
- 439061
- Product name
- (?)-Isopulegol
- Purity
- 99%
- Packaging
- 1ml
- Price
- $67.1
- Updated
- 2024/03/01
- Product number
- 04570595
- Product name
- (?)-Isopulegol
- Purity
- primary reference standard
- Packaging
- 50mg
- Price
- $314
- Updated
- 2023/06/20
- Product number
- 23161
- Product name
- (?)-Isopulegol
- Purity
- ≥98%
- Packaging
- 25g
- Price
- $49
- Updated
- 2024/03/01
- Product number
- 23161
- Product name
- (?)-Isopulegol
- Purity
- ≥98%
- Packaging
- 50g
- Price
- $92
- Updated
- 2024/03/01
ISOPULEGOL Chemical Properties,Usage,Production
Description
Synthesis: Several stereoisomers are possible; only l-isopulegol and d-α-isopulegol have been isolated from mixtures of alcohols obtained by cyclization of d-citronellal.
Description
(–)-Isopulegol is a monoterpene that has been found in the essential oils of several aromatic plants, including Cannabis, with diverse biological activities. It has antibacterial activity against S. aureus, E. faecium, E. coli, and M. smegmatis (MICs = 0.78, 12.5, 0.78, and 1.56 μl/ml, respectively, in an agar diffusion assay) and antifungal activity against C. albicans and A. niger (MIC = 1.56 μl/ml for both in an agar diffusion assay). (–)-Isopulegol inhibits C. albicans morphogenesis, adhesion, and biofilm formation (MICs = 0.125, 4, and 0.25 mg/ml, respectively). In vivo, (–)-isopulegol (50 mg/kg, i.p.) increases immobility time in the forced swim and tail suspension tests and increases the number of head dips in a hole board test and time spent in the open arms of the elevated plus maze in mice, indicating depressant- and anxiolytic-like activity. It reduces the size of ulcerated lesions in the stomach in mouse models of ethanol- and indomethacin-induced gastric lesions when administered at a dose of 100 mg/kg.
Chemical Properties
Isopulegol is a cyclic nonaromatic alcohol.
Chemical Properties
Water-white liquid; mint-like odor. Combustible. Available forms: The acetate.
Occurrence
l-Isopulegol has been reported found in the essences of lemongrass, East African geranium and Eucalyptus citriodora; d-isopulegol is present in the oils of Backhousia and Baeckea citriodorae; d-neoisopulegol is found in Mentha rotundifolia. Also reported found in mint, mandarin, orange juice, citrus peel oils, currant bud, ginger, corn mint oil, cognac, rum, buchu oil, lemon balm and mastic gum oil
Uses
Perfumery (geranium and rose compounds), flavoring.
Uses
(?)-Isopulegol can be used as a starting material for the enantioselective preparation of:??????
- 8-arylmenthols by Smiles-Truce rearrangement of aryl sulfonates.,·????????
- Stereoisomers of 5,9-dimethylpentadecane.
- Octahydro-2H-chromen-4-ol by Prins cyclization with vanillin in the presence of montmorillonite clay as the catalyst.?????
- p-menthane-3,8,9-triol by catalytic Sharpless dihydroxylation.
Preparation
Several stereoisomers are possible; only l-isopulegol and d-α-isopulegol have been isolated from mixtures of alcohols obtained by cyclization of d-citronellal.
Definition
ChEBI: A natural product found in Citrus hystrix.
Aroma threshold values
Detection: 1 ppm
Taste threshold values
Taste characteristics at 30 ppm: minty cooling, herbaceous peppermint nuance.
Synthesis Reference(s)
Synthetic Communications, 18, p. 2309, 1988 DOI: 10.1080/00397918808082375
General Description
Isopulegol is monoterpene alcohol, a useful ingredient for the production of fragrances in perfume industries. It is also used as a starting material in the manufacture of menthol by the hydrogenation process. Menthol is an important component in cosmetics, pharmaceuticals, and toothpaste.
Flammability and Explosibility
Non flammable
ISOPULEGOL Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from ISOPULEGOL manufacturers
- Product
- ISOPULEGOL 89-79-2
- Price
- US $40.00-40.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 10 tons
- Release date
- 2023-09-27
- Product
- ISOPULEGOL 89-79-2
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2022-12-06
- Product
- ISOPULEGOL 89-79-2
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2023-06-28