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SIB 1893

Product Name
SIB 1893
CAS No.
6266-99-5
Chemical Name
SIB 1893
Synonyms
SIB 1893;NSC 36665;(E/Z)-SIB-1893;(E/Z)SIB1893,(E/Z) SIB 1893;(E)-2-METHYL-6-STYRYL-PYRIDINE;2-METHYL-6-(2-PHENYLETHENYL)PYRIDINE;(E)-2-METHYL-6-(2-PHENYLETHYL)-PYRIDINE;Pyridine, 2-methyl-6-(2-phenylethenyl)-;2-Methyl-6-[(E)-2-phenylethenyl]pyridine
CBNumber
CB5393055
Molecular Formula
C14H13N
Formula Weight
195.26
MOL File
6266-99-5.mol
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SIB 1893 Property

storage temp. 
2-8°C
solubility 
DMSO: 18 mg/mL
form 
solid
color 
White to off-white
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris
Product number
1214
Product name
SIB 1893
Packaging
10
Price
$118
Updated
2021/12/16
Tocris
Product number
1214
Product name
SIB 1893
Packaging
50
Price
$495
Updated
2021/12/16
TRC
Product number
S411003
Product name
SIB 1893
Packaging
10mg
Price
$80
Updated
2021/12/16
Usbiological
Product number
256664
Product name
SIB 1893
Packaging
10mg
Price
$389
Updated
2021/12/16
ApexBio Technology
Product number
B6635
Product name
SIB 1893
Packaging
10mg
Price
$228
Updated
2021/12/16
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SIB 1893 Chemical Properties,Usage,Production

Uses

SIB 1893 is a selective antagonist of mGluR-5. SIB 1893 acts as a positive allosteric modulator of human metabotropic mGlu4 (1). Anticonvulsant (2).

Definition

ChEBI: 2-methyl-6-(2-phenylethenyl)pyridine is a member of styrenes.

Biological Activity

A highly selective non-competitive antagonist for the metabotropic glutamate mGlu 5 receptor subtype; displays an IC 50 value of 0.3 μ M? at hmGlu 5 , compared with > 100 μ M at hmGlu 1b , hmGlu 2 , hmGlu 6 , hmGlu 7 and hmGlu 8 . Centrally active upon systemic administration in vivo . Positive allosteric modulator at mGlu 4 receptors.

SIB 1893 Preparation Products And Raw materials

Raw materials

Preparation Products

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SIB 1893 Suppliers

China 29 Germany 2 Japan 1 Switzerland 2 United Kingdom 2 United States 5 USA 1 Global 42

6266-99-5, SIB 1893Related Search:

ETHYLENE stilbazium iodide SIB 1893 4-(1,3-BENZODIOXOL-5-YL)-2-[(E)-2-(3-NITROPHENYL)ETHENYL]-5-OXO-5H-INDENO[1,2-B]PYRIDINE-3-CARBONITRILE 4-(1,3-BENZODIOXOL-5-YL)-2-(4-METHOXYSTYRYL)-5-OXO-5H-INDENO[1,2-B]PYRIDINE-3-CARBONITRILE 4-(1,3-BENZODIOXOL-5-YL)-2-[(E)-2-(3-BROMOPHENYL)ETHENYL]-5-OXO-5H-INDENO[1,2-B]PYRIDINE-3-CARBONITRILE 4-(1,3-BENZODIOXOL-5-YL)-2-[(E)-2-(2-CHLOROPHENYL)ETHENYL]-5-OXO-5H-INDENO[1,2-B]PYRIDINE-3-CARBONITRILE 2-[(E)-2-(4-FLUOROPHENYL)ETHENYL]-5-OXO-4-(3,4,5-TRIMETHOXYPHENYL)-5H-INDENO[1,2-B]PYRIDINE-3-CARBONITRILE 4-(1,3-BENZODIOXOL-5-YL)-2-[(E)-2-(3-CHLOROPHENYL)ETHENYL]-5-OXO-5H-INDENO[1,2-B]PYRIDINE-3-CARBONITRILE 4-(1,3-BENZODIOXOL-5-YL)-2-(3,4-DICHLOROSTYRYL)-5-OXO-5H-INDENO[1,2-B]PYRIDINE-3-CARBONITRILE 4-(1,3-BENZODIOXOL-5-YL)-2-[(E)-2-(4-FLUOROPHENYL)ETHENYL]-5-OXO-5H-INDENO[1,2-B]PYRIDINE-3-CARBONITRILE 4-(1,3-BENZODIOXOL-5-YL)-2-[(E)-2-(4-CHLOROPHENYL)ETHENYL]-5H-INDENO[1,2-B]PYRIDIN-5-ONE 4-(2-FLUOROPHENYL)-2-[(E)-2-(3-METHOXYPHENYL)ETHENYL]-5-OXO-5H-INDENO[1,2-B]PYRIDINE-3-CARBONITRILE 2-[(E)-2-(3-CHLOROPHENYL)ETHENYL]-4-(4-HEPTYLPHENYL)-5-OXO-5H-INDENO[1,2-B]PYRIDINE-3-CARBONITRILE 4-(1,3-BENZODIOXOL-5-YL)-2-[(E)-2-(2-FLUOROPHENYL)ETHENYL]-5-OXO-5H-INDENO[1,2-B]PYRIDINE-3-CARBONITRILE 4-(1,3-BENZODIOXOL-5-YL)-2-(4-HYDROXYSTYRYL)-5-OXO-5H-INDENO[1,2-B]PYRIDINE-3-CARBONITRILE 4-(1,3-BENZODIOXOL-5-YL)-2-(4-NITROSTYRYL)-5-OXO-5H-INDENO[1,2-B]PYRIDINE-3-CARBONITRILE

  • SIB 1893
  • 2-METHYL-6-(2-PHENYLETHENYL)PYRIDINE
  • (E)-2-METHYL-6-(2-PHENYLETHYL)-PYRIDINE
  • (E)-2-METHYL-6-STYRYL-PYRIDINE
  • 2-Methyl-6-[(E)-2-phenylethenyl]pyridine
  • NSC 36665
  • Pyridine, 2-methyl-6-(2-phenylethenyl)-
  • (E/Z)-SIB-1893
  • (E/Z)SIB1893,(E/Z) SIB 1893
  • 6266-99-5
  • Glutamate receptor