DM4-Sme

Product Name: DM4-Sme
CAS No.: 796073-68-2
Chemical Name: DM4-Sme
Synonyms: DM4-Sme;Maytansinoid DM4 Impurity 1;Maytansinoid DM4 Impurity 1-d6;Maytansine, N2'-deacetyl-N2'-[4-methyl-4-(methyldithio)-1-oxopentyl]-
CBNumber: CB53959872
Molecular Formula: C39H56ClN3O10S2
Formula Weight: 826.46
MOL File: 796073-68-2.mol

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DM4-Sme Property

Boiling point:: 963.8±65.0 °C(Predicted)
Density: 1.30±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: Solid
pka: 9.82±0.70(Predicted)
color: White to off-white
InChIKey: LTLNAIFGVAUBEJ-GPEBISKRNA-N

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0104947
Product name: DM4-SMe
Purity: ≥98.0%
Packaging: 5mg
Price: $495
Updated: 2021/12/16

ChemScene

Product number: CS-0104947
Product name: DM4-SMe
Purity: ≥98.0%
Packaging: 10mg
Price: $750
Updated: 2021/12/16

ChemScene

Product number: CS-0104947
Product name: DM4-SMe
Purity: ≥98.0%
Packaging: 25mg
Price: $1550
Updated: 2021/12/16

ChemScene

Product number: CS-0104947
Product name: DM4-SMe
Purity: ≥98.0%
Packaging: 50mg
Price: $2550
Updated: 2021/12/16

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DM4-Sme Chemical Properties,Usage,Production

Description

DM4-SMe is a metabolite of antibody-maytansin conjugates (AMCs) and a tubulin inhibitor, and also a cytotoxic moiety of antibody-drug conjugates (ADCs), which can be linked to antibody through disulfide bond or stable thioether bond. DM4-SMe inhibits KB cells with an IC50 of 0.026 nM[1][2].

References

[1]. Widdison W, et al. Metabolites of antibody-maytansinoid conjugates: characteristics and in vitro potencies. Mol Pharm. 2015 Jun 1;12(6):1762-73. [2]. Chen H, et al. Tubulin Inhibitor-Based Antibody-Drug Conjugates for Cancer Therapy. Molecules. 2017 Aug 1;22(8).

DM4-Sme Preparation Products And Raw materials

Raw materials

Preparation Products

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DM4-Sme Suppliers

China 8 United States 3 Global 11

Fan De(Beijing) Biotechnology Co., Ltd.

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CHENGDU JINMAIRUI BIO-TECHNOLOGY CO.LTD

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Henan Vcommend Consultrading Co., Ltd.

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ChemExpress

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Shanghai Hao Zhun Biological Technology Co., Ltd.

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796073-68-2, DM4-SmeRelated Search:

DM4-Sme

Maytansine, N2'-deacetyl-N2'-[4-methyl-4-(methyldithio)-1-oxopentyl]-

Maytansinoid DM4 Impurity 1

Maytansinoid DM4 Impurity 1-d6

796073-68-2