EBI-2511

Product Name: EBI-2511
CAS No.: 2098546-05-3
Chemical Name: EBI-2511
Synonyms: EBI-2511;EBI-2511;EBI2511;EBI 2511;;Histone Methyltransferase,Inhibitor,EBI-2511,inhibit,EBI 2511,EBI2511;N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-5-ethyl-6-[ethyl(oxan-4-yl)amino]-2-(1-propan-2-ylpiperidin-4-yl)-1-benzofuran-4-carboxamide;N-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-5-ethyl-6-[ethyl(oxan-4-yl)amino]-2-[1-(propan-2-yl)piperidin-4-yl]-1-benzofuran-4-carboxamide;4-Benzofurancarboxamide, N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-5-ethyl-6-[ethyl(tetrahydro-2H-pyran-4-yl)amino]-2-[1-(1-methylethyl)-4-piperidinyl]-
CBNumber: CB53960140
Molecular Formula: C34H48N4O4
Formula Weight: 576.77
MOL File: 2098546-05-3.mol

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EBI-2511 Property

storage temp.: Store at -20°C
solubility: DMSO : 5 mg/mL (8.67 mM)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0040564
Product name: EBI-2511
Purity: 99.38%
Packaging: 5mg
Price: $180
Updated: 2021/12/16

ChemScene

Product number: CS-0040564
Product name: EBI-2511
Purity: 99.38%
Packaging: 10mg
Price: $280
Updated: 2021/12/16

ChemScene

Product number: CS-0040564
Product name: EBI-2511
Purity: 99.38%
Packaging: 25mg
Price: $580
Updated: 2021/12/16

ChemScene

Product number: CS-0040564
Product name: EBI-2511
Purity: 99.38%
Packaging: 50mg
Price: $850
Updated: 2021/12/16

ChemScene

Product number: CS-0040564
Product name: EBI-2511
Purity: 99.38%
Packaging: 100mg
Price: $1350
Updated: 2021/12/16

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EBI-2511 Chemical Properties,Usage,Production

Uses

EBI-2511 is a highly potent and orally active EZH2 inhibitor, with an IC50 of 6 nM in Pfeffiera cell lines, respectively.

in vivo

EBI-2511 displays a dose-dependent inhibition on the tumor growth, resulting in 28% (10mg/kg), 83% (30mg/kg), and 97% (100mg/kg) reduction in tumor size. At the same dosage level, EBI-2511 shows a superior anti-tumor efficacy to EPZ-6438 (P<0.01). It is noteworthy that no significant changes in body weights of all treatment groups are observed^[1].

IC 50

EZH2

References

[1] Lu B, et al. Discovery of EBI-2511: A Highly Potent and Orally Active EZH2 Inhibitor for the Treatment of Non-Hodgkin's Lymphoma. ACS Med Chem Lett. 2018 Jan 29;9(2):98-102. DOI:10.1021/acsmedchemlett.7b00437

EBI-2511 Preparation Products And Raw materials

Raw materials

Preparation Products

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EBI-2511 Suppliers

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View Lastest Price from EBI-2511 manufacturers

PNP Biotech Co. Ltd

Product: EBI-2511 2098546-05-3
Price: US $0.00/kg
Min. Order: 25kg
Purity: 98%-99%
Supply Ability: Inquiry
Release date: 2022-09-16

2098546-05-3, EBI-2511Related Search:

EBI-2511

N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-5-ethyl-6-[ethyl(oxan-4-yl)amino]-2-(1-propan-2-ylpiperidin-4-yl)-1-benzofuran-4-carboxamide

EBI-2511;EBI2511;EBI 2511;

4-Benzofurancarboxamide, N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-5-ethyl-6-[ethyl(tetrahydro-2H-pyran-4-yl)amino]-2-[1-(1-methylethyl)-4-piperidinyl]-

Histone Methyltransferase,Inhibitor,EBI-2511,inhibit,EBI 2511,EBI2511

N-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-5-ethyl-6-[ethyl(oxan-4-yl)amino]-2-[1-(propan-2-yl)piperidin-4-yl]-1-benzofuran-4-carboxamide

2098546-05-3

C34H48N4O4