4-Aminopyridine-2-carboxylic acid
- Product Name
- 4-Aminopyridine-2-carboxylic acid
- CAS No.
- 100047-36-7
- Chemical Name
- 4-Aminopyridine-2-carboxylic acid
- Synonyms
- 4-AMINOPICOLINIC ACID;IFLAB-BB F1926-0040;4-Aminopicolinic acid - [A12444];4-AMINOPYRIDINE-2-CARBOXYLIC ACID;2-Pyridinecarboxylic acid, 4-amino-;4-Aminopyridine-2-carboxylic acid 97%;4-Aminopyridine-2-carboxylic acid ,97%;2-Pyridinecarboxylicacid,4-amino-(9CI);4-Aminopyridine-2-carboxylic acid USP/EP/BP;100047-36-4-aminopyridine-2-carboxylic Acid7
- CBNumber
- CB5401109
- Molecular Formula
- C6H6N2O2
- Formula Weight
- 138.12
- MOL File
- 100047-36-7.mol
4-Aminopyridine-2-carboxylic acid Property
- Melting point:
- 265 °C
- Boiling point:
- 446.3±30.0 °C(Predicted)
- Density
- 1.417±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- solubility
- Acetone, Ethanol, Methanol
- form
- Solid
- pka
- 1.37±0.50(Predicted)
- Appearance
- Off-white to yellow Solid
- InChI
- InChI=1S/C6H6N2O2/c7-4-1-2-8-5(3-4)6(9)10/h1-3H,(H2,7,8)(H,9,10)
- InChIKey
- JRZBTJVSAANBEV-UHFFFAOYSA-N
- SMILES
- C1(C(O)=O)=NC=CC(N)=C1
- CAS DataBase Reference
- 100047-36-7(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 22-36/37/38-20/21/22
- Safety Statements
- 50A-24/25-36/37/39
- RIDADR
- 2761
- Hazard Note
- Irritant
- HS Code
- 29333990
N-Bromosuccinimide Price
- Product number
- CDS007808
- Product name
- 4-aminopyridine-2-carboxylic acid
- Purity
- Aldrich
- Packaging
- 250mg
- Price
- $73.1
- Updated
- 2025/07/31
- Product number
- A627805
- Product name
- 4-AminopicolinicAcid
- Packaging
- 5g
- Price
- $580
- Updated
- 2021/12/16
- Product number
- A627805
- Product name
- 4-AminopicolinicAcid
- Packaging
- 25g
- Price
- $2475
- Updated
- 2021/12/16
- Product number
- JK142952
- Product name
- 4-aminopyridine-2-carboxylic acid
- Purity
- 97%
- Packaging
- 5g
- Price
- $560
- Updated
- 2021/12/16
- Product number
- 6759
- Product name
- 4-AminopicolinicAcid
- Packaging
- 50mg
- Price
- $1760
- Updated
- 2021/12/16
4-Aminopyridine-2-carboxylic acid Chemical Properties,Usage,Production
Description
4-Aminopyridine-2-carboxylic acid is an organic synthetic reagent used in the preparation of 4-amino-6-(heterocyclic)pyridine carboxylic acid esters, 4-amino-2,6-dimethylnicotinic acid esters and amides.
Chemical Properties
White solid
Uses
4-Aminopyridine-2-carboxylic acid can be a useful synthetic intermediate
Synthesis
1918-02-1
100047-36-7
General procedure for the synthesis of 4-aminopyridine-2-carboxylic acid from 4-amino-3,5,6-trichloropyridine-2-carboxylic acid: a thick suspension formed by Picloram (8 g, 33 mmol) and 10% Pd/C (1.2 g) in a 10% aqueous LiOH solution (44 mL) was purged twice with hydrogen, and then under a hydrogen atmosphere (45 PSI) at 40°C for 4 hours with stirring. Subsequently, the mixture was heated to 70°C and maintained for 12 hours. Upon completion of the reaction, the cooled suspension was filtered through diatomaceous earth. The filtrate was acidified to pH=3 in concentrated HCl (~3.5 mL), at which point a precipitate was generated. The solid product was collected by filtration and dried overnight under high vacuum to give the final 4-aminopyridine-2-carboxylic acid as a beige solid (4.6 g, 99% yield).LCMS analysis showed m/z 139.1 (M + H)+ with a retention time of 0.21 minutes.
References
[1] Patent: WO2012/3576, 2012, A1. Location in patent: Page/Page column 96
4-Aminopyridine-2-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Aminopyridine-2-carboxylic acid manufacturers
- Product
- 4-Aminopyridine-2-carboxylic acid 100047-36-7
- Price
- US $10.00/ASSAYS
- Min. Order
- 1ASSAYS
- Purity
- 99%
- Supply Ability
- 1 ton
- Release date
- 2025-08-27
- Product
- 4-Aminopyridine-2-carboxylic acid 100047-36-7
- Price
- US $0.01/KG
- Min. Order
- 1KG
- Purity
- 98%;99%
- Supply Ability
- 1kg； 5kg；10kg；25kg
- Release date
- 2020-01-07