5-BROMO-2-ISOPROPOXYPYRIDINE
- Product Name
- 5-BROMO-2-ISOPROPOXYPYRIDINE
- CAS No.
- 870521-31-6
- Chemical Name
- 5-BROMO-2-ISOPROPOXYPYRIDINE
- Synonyms
- 5-BroMo-2-isopropylpyridine;5-BROMO-2-ISOPROPOXYPYRIDINE;3-Bromo-6-(i-propoxy)pyridine;5-BroMo-2-isopropyloxypyridine;5-broMo-2-(propan-2-yloxy)pyridine;Pyridine, 5-bromo-2-(1-methylethoxy)-;5-BROMO-2-ISOPROPOXYPYRIDINE ISO 9001：2015 REACH
- CBNumber
- CB5402737
- Molecular Formula
- C8H10BrNO
- Formula Weight
- 216.08
- MOL File
- 870521-31-6.mol
5-BROMO-2-ISOPROPOXYPYRIDINE Property
- Boiling point:
- 228.3±20.0 °C(Predicted)
- Density
- 1.383±0.06 g/cm3(Predicted)
- refractive index
- 1.5305
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- 1.88±0.22(Predicted)
- Appearance
- Colorless to light yellow Liquid
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-37/38-41
- Safety Statements
- 26-39
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- B696468
- Product name
- 5-Bromo-2-isopropoxypyridine
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- B696468
- Product name
- 5-Bromo-2-isopropoxypyridine
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- B696468
- Product name
- 5-Bromo-2-isopropoxypyridine
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- CS-0038218
- Product name
- 5-Bromo-2-isopropoxypyridine
- Purity
- 99.53%
- Packaging
- 5g
- Price
- $98
- Updated
- 2021/12/16
- Product number
- Y6445
- Product name
- 5-Bromo-2-isopropoxypyridine
- Packaging
- 5g
- Price
- $231
- Updated
- 2021/12/16
5-BROMO-2-ISOPROPOXYPYRIDINE Chemical Properties,Usage,Production
Uses
5-Bromo-2-isopropylpyridine is used to prepare azepino[4,?5-?b]?indoles as histamine receptor modulators for treating cognitive and psychotic disorders.
Synthesis
75-30-9
13466-38-1
870521-31-6
The general procedure for the synthesis of 5-bromo-2-isopropoxypyridine from 2-iodopropane and 2-hydroxy-5-bromopyridine was as follows: with reference to Example 17, 5-bromo-2-isopropoxypyridine was prepared as follows: 5-bromopyridin-2(1H)-one (5 g, 28.7 mmol) and potassium carbonate (9.93 g, 71.8 mmol) were mixed in dimethyl sulfoxide. 2-Iodopropane (3.73 ml, 37.3 mmol) was slowly added to the reaction mixture at room temperature and stirred continuously at the same temperature for 4 hours. After completion of the reaction, the reaction solution was diluted with ethyl acetate and washed sequentially with water and saturated saline. The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure to remove the solvent. The resulting crude product was purified by silica gel column chromatography (eluent ratio: ethyl acetate/hexane = 20/80 to 50/50) to afford the target compound 5-bromo-2-isopropoxypyridine (4.72 g, 76% yield) as a colorless oil. Its 1H-NMR (400 MHz, CDCl3) data were as follows: δ1.33 (6H, d, J=6.3 Hz), 5.18-5.28 (1H, m), 6.59 (1H, d, J=8.8 Hz), 7.61 (1H, dd, J=8.8,2.9 Hz), 8.17 (1H, d, J=2.0 Hz).
References
[1] Patent: EP1892241, 2008, A1. Location in patent: Page/Page column 124
[2] ACS Medicinal Chemistry Letters, 2018, vol. 9, # 7, p. 761 - 767
[3] Patent: WO2005/123675, 2005, A1. Location in patent: Page/Page column 54
5-BROMO-2-ISOPROPOXYPYRIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-BROMO-2-ISOPROPOXYPYRIDINE manufacturers
- Product
- 5-BROMO-2-ISOPROPOXYPYRIDINE 870521-31-6
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-08-23
- Product
- 5-Bromo-2-Isopropoxypyridine 870521-31-6
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 500 MT
- Release date
- 2020-05-12