ChemicalBook > CAS DataBase List > 903564-48-7

903564-48-7

Product Name
903564-48-7
CAS No.
903564-48-7
Chemical Name
903564-48-7
Synonyms
UM-164;CS-2793;DAS-DFGO-II;UM164;UM-164;UM 164;UM-164 (DAS-DFGO-II);p38 MAPK,Autophagy,UM-164,Src,UM 164,inhibit,Inhibitor;2-((6-(4-(2-Hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-yl)amino)-N-(2-methyl-5-(3-(trifluoromethyl)benzamido)phenyl)thiazole-5-carboxamide;5-Thiazolecarboxamide, 2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-N-[2-methyl-5-[[3-(trifluoromethyl)benzoyl]amino]phenyl]-
CBNumber
CB54033656
Molecular Formula
C30H31F3N8O3S
Formula Weight
640.68
MOL File
903564-48-7.mol
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903564-48-7 Property

Density 
1.433±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO: 5 mg/ml
form 
A crystalline solid
pka
11.40±0.70(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
26188
Product name
UM-164
Packaging
1mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
26188
Product name
UM-164
Packaging
5mg
Price
$140
Updated
2024/03/01
Cayman Chemical
Product number
26188
Product name
UM-164
Packaging
10mg
Price
$257
Updated
2024/03/01
Cayman Chemical
Product number
26188
Product name
UM-164
Packaging
25mg
Price
$533
Updated
2024/03/01
ChemScene
Product number
CS-0043628
Product name
UM-164
Purity
99.08%
Packaging
50mg
Price
$690
Updated
2021/12/16
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903564-48-7 Chemical Properties,Usage,Production

Biological Activity

UM-164 (DAS-DFGO-II) is a potent c-Src inhibitor with Kd of 2.7 nM. It also highly inhibits p38α and p38β activity.

in vitro

In biochemical assays, UM-164 is a highly potent inhibitor of c-Src with a binding constant comparable with Dasatinib (UM-164 K d =2.7 nM, Dasatinib K d =0.7 nM). To confirm that UM-164 is capable of inhibiting the activation of c-Src in vitro, the effect of UM-164 is examined on the c-Src autophosphorylation in two TNBC cell lines ( MDA-MB 231 and SUM 149). Inhibition of c-Src autophosphorylation is detected in a concentration- and a time-dependent manner. At 120 minutes, complete abrogation of c-Src autophosphorylation is observed at 50 nM, demonstrating that UM-164 is a potent c-Src inhibitor in vitro. Flow cytometry experiments demonstrate that UM-164 treatment of MDA-MB 231 and SUM 149 increased the proportion of G 0 -G 1 cells by 25% and 28%, respectively, and concurrently decreased the fraction of S cells by 16% and 19%, respectively.

in vivo

A xenograft study is performed using NCr/nude mice implanted with MDA-MB 231 and SUM 149 cell lines. Once the tumors become palpable, the mice are randomized into control and treatment groups. Mice are injected intraperitoneally with either drug (10 and 20 mg/kg in both xenograft studies; a 15 mg/kg dose is added to the SUM 149 xenograft studies) or vehicle every other day (n=5 for each group). At the selected doses of UM-164 , there is no significant weight loss or gross abnormalities observed in the treated animals, even after 52 days of treatment. However, tumor growth is significantly inhibited in both the 10 mg/kg and 20 mg/kg dose groups compared with the vehicle-treated group (P<0.026 and P<0.004, respectively).

target

p38α

p38β

c-Src

2.7 nM (Kd)

903564-48-7 Preparation Products And Raw materials

Raw materials

Preparation Products

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903564-48-7 Suppliers

China 46 United States 7 Global 53
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32165
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
Cckinase, Inc.
Tel
+1 (732)236-3202
Email
sales@cckinase.com
Country
United States
ProdList
2738
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
TargetMol Chemicals Inc.
Tel
Email
support@targetmol.com
Country
United States
ProdList
38632
Advantage
58
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
MedChemExpress
Tel
--
Fax
--
Email
sales@medchemexpress.com
Country
United States
ProdList
6398
Advantage
58

903564-48-7, 903564-48-7Related Search:


  • UM-164
  • DAS-DFGO-II
  • CS-2793
  • UM164;UM-164;UM 164
  • UM-164 (DAS-DFGO-II)
  • 5-Thiazolecarboxamide, 2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-N-[2-methyl-5-[[3-(trifluoromethyl)benzoyl]amino]phenyl]-
  • p38 MAPK,Autophagy,UM-164,Src,UM 164,inhibit,Inhibitor
  • 2-((6-(4-(2-Hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-yl)amino)-N-(2-methyl-5-(3-(trifluoromethyl)benzamido)phenyl)thiazole-5-carboxamide
  • 903564-48-7
  • C30H31F3N8O3S