3-(2-BROMO-4-FLUORO-PHENYL)-PROPIONIC ACID

Product Name: 3-(2-BROMO-4-FLUORO-PHENYL)-PROPIONIC ACID
CAS No.: 174603-55-5
Chemical Name: 3-(2-BROMO-4-FLUORO-PHENYL)-PROPIONIC ACID
Synonyms: Benzenepropanoic acid, 2-broMo-4-fluoro-;3-(2-broMo-4-fluorophenyl)propanoic acid;3-(2-BROMO-4-FLUORO-PHENYL)-PROPIONIC ACID
CBNumber: CB5407611
Molecular Formula: C9H8BrFO2
Formula Weight: 247.06
MOL File: 174603-55-5.mol

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3-(2-BROMO-4-FLUORO-PHENYL)-PROPIONIC ACID Property

Boiling point:: 331.4±27.0 °C(Predicted)
Density: 1.606±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 4.59±0.10(Predicted)
Appearance: White to off-white Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific

Product number: W3815
Product name: 3-(2-Bromo-4-fluorophenyl)propionicacid
Packaging: 2.5g
Price: $1602
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0049569
Product name: 3-(2-BROMO-4-FLUORO-PHENYL)-PROPIONIC ACID
Purity: 95.00%
Packaging: 5G
Price: $1784.48
Updated: 2021/12/16

AK Scientific

Product number: W3815
Product name: 3-(2-Bromo-4-fluorophenyl)propionicacid
Packaging: 10g
Price: $3357
Updated: 2021/12/16

Ambeed

Product number: A162701
Product name: 3-(2-Bromo-4-fluorophenyl)propionicacid
Purity: 97%
Packaging: 100mg
Price: $51
Updated: 2021/12/16

Ambeed

Product number: A162701
Product name: 3-(2-Bromo-4-fluorophenyl)propionicacid
Purity: 97%
Packaging: 250mg
Price: $84
Updated: 2021/12/16

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3-(2-BROMO-4-FLUORO-PHENYL)-PROPIONIC ACID Chemical Properties,Usage,Production

Synthesis

174603-54-4

174603-55-5

Diethyl 2-(2-bromo-4-fluorobenzyl)-malonate (2.1 g, 6.07 mmol) was used as a raw material, which was mixed with water (14 mL) and potassium hydroxide (0.68 g, 12.14 mmol) was added. The reaction mixture was heated under reflux conditions for 4.5 hours. Upon completion of the reaction, the mixture was cooled to room temperature and ethanol was removed by distillation under reduced pressure. The aqueous residue was cooled to 100°C, acidified with concentrated sulfuric acid and subsequently heated at 120°C for 16 hours. After the reaction mixture was cooled to 0°C, the precipitated solid was collected by filtration, washed with water and dried to afford 3-(2-bromo-4-fluorophenyl)propionic acid as an off-white solid (0.5 g, 33% yield). Thin layer chromatography (TLC) showed an Rf value of 0.2 (unfolding agent: 30% ethyl acetate/petroleum ether).1H NMR (400 MHz, DMSO-d6) data were as follows: δ 12.26 (s, 1H), 7.55-7.52 (m, 1H), 7.42-7.38 (m, 1H), 7.23-7.18 (m, 1H), 2.90 (t. J = 7.8 Hz, 2H), 2.52 (t, J = 7.8 Hz, 2H).

References

[1] Journal of Medicinal Chemistry, 2003, vol. 46, # 3, p. 409 - 416
[2] Patent: WO2015/36759, 2015, A1. Location in patent: Page/Page column 171

3-(2-BROMO-4-FLUORO-PHENYL)-PROPIONIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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3-(2-BROMO-4-FLUORO-PHENYL)-PROPIONIC ACID Suppliers

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View Lastest Price from 3-(2-BROMO-4-FLUORO-PHENYL)-PROPIONIC ACID manufacturers

Career Henan Chemical Co

Product: 3-(2-Bromo-4-fluorophenyl)propionic acid 174603-55-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: Min98% HPLC
Supply Ability: g/kg/ton
Release date: 2020-01-30

174603-55-5, 3-(2-BROMO-4-FLUORO-PHENYL)-PROPIONIC ACIDRelated Search:

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3-(2-BROMO-4-FLUORO-PHENYL)-PROPIONIC ACID

3-(2-broMo-4-fluorophenyl)propanoic acid

Benzenepropanoic acid, 2-broMo-4-fluoro-

174603-55-5