ETHYL 2-CHLOROPYRIMIDINE-4-CARBOXYLATE
- Product Name
- ETHYL 2-CHLOROPYRIMIDINE-4-CARBOXYLATE
- CAS No.
- 1196152-00-7
- Chemical Name
- ETHYL 2-CHLOROPYRIMIDINE-4-CARBOXYLATE
- Synonyms
- ETHYL 2-CHLOROPYRIMIDINE-4-CARBOXYLATE;2-Chloro-pyrimidine-4-carboxylic acid ethyl ester;4-PyriMidinecarboxylic acid, 2-chloro-, ethyl ester;2-Chloro-4-(ethoxycarbonyl)pyrimidine, 2-Chloro-4-(ethoxycarbonyl)-1,3-diazine
- CBNumber
- CB5410044
- Molecular Formula
- C7H7ClN2O2
- Formula Weight
- 186.6
- MOL File
- Mol file
ETHYL 2-CHLOROPYRIMIDINE-4-CARBOXYLATE Property
- Boiling point:
- 314.2±15.0 °C(Predicted)
- Density
- 1.311±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -3.71±0.20(Predicted)
- Appearance
- Light yellow to green yellow Solid
Safety
- HS Code
- 2933599590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- E938268
- Product name
- Ethyl2-Chloropyrimidine-4-carboxylate
- Packaging
- 50mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- 3372AA
- Product name
- Ethyl2-chloropyrimidine-4-carboxylate
- Packaging
- 250mg
- Price
- $122
- Updated
- 2021/12/16
- Product number
- C12996
- Product name
- Ethyl2-chloropyrimidine-4-carboxylate
- Purity
- 95%
- Packaging
- 1g
- Price
- $150
- Updated
- 2021/12/16
- Product number
- 3372AA
- Product name
- Ethyl2-chloropyrimidine-4-carboxylate
- Packaging
- 1g
- Price
- $190
- Updated
- 2021/12/16
- Product number
- HCH0355963
- Product name
- ETHYL-2-CHLOROPYRIMIDINE-4-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $498.25
- Updated
- 2021/12/16
ETHYL 2-CHLOROPYRIMIDINE-4-CARBOXYLATE Chemical Properties,Usage,Production
Synthesis
149849-92-3
64-17-5
1196152-00-7
To 2-chloropyrimidine-4-carboxylic acid (9.A, 1.00 g, 6.3 mmol) and ethanol (0.32 g, 6.9 mmol) in dichloromethane (DCM, 10 ml) was added 1,3-dicyclohexylcarbodiimide (DCC, 1.4 g, 6.9 mmol) and the reaction mixture was stirred at room temperature overnight. After completion of the reaction, the solid by-products were removed by filtration. The filtrate was diluted by adding DCM (80 ml) and subsequently washed with brine (30 ml) and dried over anhydrous magnesium sulfate (MgSO4). The solvent was removed by evaporation under reduced pressure to give the crude product. The crude product was purified by Combi-Flash silica gel column chromatography to afford the target compound ethyl 2-chloropyrimidine-4-carboxylate (9.B, 0.74 g, 63% yield). The product was confirmed by 1H NMR (400 MHz, CDCl3): δ 8.87 (1H, d, J=4.7 Hz), 7.95 (1H, d, J=4.7 Hz), 4.51 (2H, q, J=7.4 Hz), 1.45 (3H, t, J=7.0 Hz). The mass spectrum (ESI+) showed m/e: 187.0 ([M+H]+).
References
[1] Patent: WO2010/93849, 2010, A2. Location in patent: Page/Page column 53
[2] Patent: WO2014/69963, 2014, A1. Location in patent: Paragraph 616-617
ETHYL 2-CHLOROPYRIMIDINE-4-CARBOXYLATE Preparation Products And Raw materials
Raw materials
Preparation Products
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