((CYS31,NVA34)-NEUROPEPTIDE Y (27-36))2

Product Name: ((CYS31,NVA34)-NEUROPEPTIDE Y (27-36))2
CAS No.: 172997-92-1
Chemical Name: ((CYS31,NVA34)-NEUROPEPTIDE Y (27-36))2
Synonyms: BWX 46;((CYS31,NVA34)-NPY (27-36))2;((Cys??,Nva??)-Neuropeptide Y (27-36))?;((CYS31,NVA34)-NEUROPEPTIDE Y (27-36))2;(H-TYR-ILE-ASN-LEU-CYS-THR-ARG-NVA-ARG-TYR-NH2)2;(H-Tyr-Ile-Asn-Leu-Cys-Thr-Arg-Nva-Arg-Tyr-NH2)2, (Disulfide bond);((Cys31, Nva 34)-Neuropeptide Y (27-36))2 (H-Tyr-Ile-Asn-Leu-Cys-Thr-Arg-Nva-Arg-Tyr-NH2)2 (Disulfide bond);L-Tyrosinamide, L-tyrosyl-L-isoleucyl-L-asparaginyl-L-leucyl-L-cysteinyl-L-threonyl-L-arginyl-L-norvalyl-L-arginyl-, bimol. (5→5')-disulfide
CBNumber: CB5412194
Molecular Formula: C116H186N36O28S2
Formula Weight: 2597.07
MOL File: 172997-92-1.mol

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((CYS31,NVA34)-NEUROPEPTIDE Y (27-36))2 Property

Density: 1.46±0.1 g/cm3(Predicted)
storage temp.: -15°C
solubility: insoluble in H2O; insoluble in EtOH; ≥260.4 mg/mL in DMSO with ultrasonic
form: solid
Water Solubility: Soluble to 10 mg/ml in water

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Usbiological

Product number: 254838
Product name: BWX 46
Packaging: 1mg
Price: $516
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC109067
Product name: ((Cys31, Nva 34)-Neuropeptide Y (27-36))2 (H-Tyr-Ile-Asn-Leu-Cys-Thr-Arg-Nva-Arg-Tyr-NH2)2 (Disulfide bond)
Packaging: 1mg
Price: $639
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC109067
Product name: ((Cys31, Nva 34)-Neuropeptide Y (27-36))2 (H-Tyr-Ile-Asn-Leu-Cys-Thr-Arg-Nva-Arg-Tyr-NH2)2 (Disulfide bond)
Packaging: 2mg
Price: $1111.3
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC109067
Product name: ((Cys31, Nva 34)-Neuropeptide Y (27-36))2 (H-Tyr-Ile-Asn-Leu-Cys-Thr-Arg-Nva-Arg-Tyr-NH2)2 (Disulfide bond)
Packaging: 100ug
Price: $106
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC109067
Product name: ((Cys31, Nva 34)-Neuropeptide Y (27-36))2 (H-Tyr-Ile-Asn-Leu-Cys-Thr-Arg-Nva-Arg-Tyr-NH2)2 (Disulfide bond)
Packaging: 250ug
Price: $210
Updated: 2021/12/16

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((CYS31,NVA34)-NEUROPEPTIDE Y (27-36))2 Chemical Properties,Usage,Production

Biological Activity

the actions of neuropeptide y (npy) are mediated by at least six g-protein coupled receptors denoted as y1, y2, y3, y4, y5, and y6. investigations using receptor selective ligands and receptor knock-out mice show that npy effects on feeding are mediated by both y1 and y5 receptors. bwx 46 is a y5 receptor selective agonist.

in vitro

bwx 46 selectively bound y5 receptors, and inhibited camp synthesis by y5 cells with potencies comparable to that of npy. in addition, bwx 46 (10 μm) exhibited no significant effect on the camp synthesis by y1, y2, and y4 cells. thus, bwx 46 constitutes the lowest molecular weight y5 selective agonist reported to date [1].

in vivo

intrahypothalamic-injection of 30 and 40 μg of bwx 46 stimulated the food intake by rats in a gradual manner, reaching maximal level 8 h after injection. this response was similar to that exhibited by other y5 selective agonists, but differed from that of npy, which exhibited a rapider orexigenic stimulus within 1 h [1].

IC 50

0.5 nm for y5

References

[1] ambikaipakan balasubramaniam, sulaiman sheriff, weixu zhai, william t. chance. bis(31/31’){[cys31, nva34]npy(27–36)-nh2}: a neuropeptide y (npy) y5 receptor selective agonist with a latent stimulatory effect on food intake in rats. peptides 23 (2002) 1485–1490

((CYS31,NVA34)-NEUROPEPTIDE Y (27-36))2 Preparation Products And Raw materials

Raw materials

Preparation Products

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((CYS31,NVA34)-NEUROPEPTIDE Y (27-36))2 Suppliers

China 46 Germany 1 The Netherlands 1 United Kingdom 2 United States 5 USA 1 Global 56

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View Lastest Price from ((CYS31,NVA34)-NEUROPEPTIDE Y (27-36))2 manufacturers

Career Henan Chemical Co

Product: ((CYS31,NVA34)-NEUROPEPTIDE Y (27-36))2 172997-92-1
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2020-02-13

172997-92-1, ((CYS31,NVA34)-NEUROPEPTIDE Y (27-36))2Related Search:

((CYS31,NVA34)-NEUROPEPTIDE Y (27-36))2

((CYS31,NVA34)-NPY (27-36))2

BWX 46

(H-TYR-ILE-ASN-LEU-CYS-THR-ARG-NVA-ARG-TYR-NH2)2

(H-Tyr-Ile-Asn-Leu-Cys-Thr-Arg-Nva-Arg-Tyr-NH2)2, (Disulfide bond)

((Cys31, Nva 34)-Neuropeptide Y (27-36))2 (H-Tyr-Ile-Asn-Leu-Cys-Thr-Arg-Nva-Arg-Tyr-NH2)2 (Disulfide bond)

L-Tyrosinamide, L-tyrosyl-L-isoleucyl-L-asparaginyl-L-leucyl-L-cysteinyl-L-threonyl-L-arginyl-L-norvalyl-L-arginyl-, bimol. (5→5')-disulfide

((Cys??,Nva??)-Neuropeptide Y (27-36))?

172997-92-1

C116H186N36O28S2