8-AZIDOADENOSINE-5'-O-DIPHOSPHATE SODIUM SALT
- Product Name
- 8-AZIDOADENOSINE-5'-O-DIPHOSPHATE SODIUM SALT
- CAS No.
- 102185-14-8
- Chemical Name
- 8-AZIDOADENOSINE-5'-O-DIPHOSPHATE SODIUM SALT
- Synonyms
- 8-N3-ADP SODIUM SALT;8-Azido-ADP disodium;-diphosphateSodiumSalt;8-Azidoadenosine-5’8-Azidoadenosine-5'-O-diphosphate sodium salt;8-Azidoadenosine-5'-diphosphate Sodium Salt;8-Azidoadenosine-5'-O-diphosphate sodium salt;8-azidoadenosine-5’-o-diphosphate(8-n3-adp),sodiumsalt;8-Azidoadenosine-5′-diphosphate Sodium Salt, CAS 102185-14-8
- CBNumber
- CB5412664
- Molecular Formula
- C10H13N8NaO10P2
- Formula Weight
- 490.2
- MOL File
- 102185-14-8.mol
8-AZIDOADENOSINE-5'-O-DIPHOSPHATE SODIUM SALT Property
- solubility
- Water: Soluble
N-Bromosuccinimide Price
- Product number
- NUC0000468
- Product name
- 8-AZIDOADENOSINE-5'-DIPHOSPHATE
- Purity
- 95.00%
- Packaging
- 1MG
- Price
- $597.89
- Updated
- 2021/12/16
- Product number
- NUC0000468
- Product name
- 8-AZIDOADENOSINE-5'-DIPHOSPHATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $808.04
- Updated
- 2021/12/16
- Product number
- NUC0000468
- Product name
- 8-AZIDOADENOSINE-5'-DIPHOSPHATE
- Purity
- 95.00%
- Packaging
- 10MG
- Price
- $972.63
- Updated
- 2021/12/16
8-AZIDOADENOSINE-5'-O-DIPHOSPHATE SODIUM SALT Chemical Properties,Usage,Production
Uses
8-Azido-ADP (disodium) is a covalent-binding inhibitor of mitochondrial adenine nucleotide translocation. 8-Azido-ADP (disodium) causes irreversible inhibition of adenine nucleotide exchange in a light-dependent reaction. 8-Azido-ADP (disodium) inhibits the normal state 4 → 3 transitions of mitochondrial respiration induced by ADP[1]. 8-Azido-ADP (disodium) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
References
[1] SchHafer G, et al. 8-azido-ADP, a covalent-binding inhibitor of mitochondrial adenine nucleotide translocation. FEBS Lett. 1976 Apr 15;64(1):185-9. DOI:10.1016/0014-5793(76)80279-7
[2] J N DHOLAKIA. Photoaffinity labeling of the rabbit reticulocyte guanine nucleotide exchange factor and eukaryotic initiation factor 2 with 8-azidopurine nucleotides. Identification of GTP- and ATP-binding domains.[J]. The Journal of Biological Chemistry, 1989, 264 34: 20638-20642.
[3] S W CHO H Y Y. Photoaffinity labeling of brain glutamate dehydrogenase isoproteins with an azido-ADP.[J]. The Journal of Biological Chemistry, 1999, 274 20: 13948-13953. DOI: 10.1074/jbc.274.20.13948
8-AZIDOADENOSINE-5'-O-DIPHOSPHATE SODIUM SALT Preparation Products And Raw materials
Raw materials
Preparation Products
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