GW7647

ChemicalBook > CAS DataBase List > GW7647

Product Name: GW7647
CAS No.: 265129-71-3
Chemical Name: GW7647
Synonyms: GW647;CS-761;GW7647;GW 7647X;GWalpha 7647;GW7647, >=98%;GW7647; GW 7647;GW7647, PPARalpha agonist;GW7647 - CAS 265129-71-3 - Calbiochem;2-(4-(2-(1-CYCLOHEXANEBUTYL)-3-CYCLOHEXYLUREIDO)ETHYL)PHENYLTHIO)-2-METHYLPROPIONIC ACID
CBNumber: CB5420133
Molecular Formula: C29H46N2O3S
Formula Weight: 502.75
MOL File: 265129-71-3.mol

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GW7647 Property

Melting point:: 156 - 157°C
Boiling point:: 693.9±55.0 °C(Predicted)
Density: 1.12
storage temp.: Store at RT
solubility: DMSO: 16 mg/mL, soluble
form: White solid
pka: 3.79±0.10(Predicted)
color: white
InChIKey: PKNYXWMTHFMHKD-UHFFFAOYSA-N

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: G6793
Product name: GW7647
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $242
Updated: 2024/03/01

Sigma-Aldrich

Product number: 370698
Product name: GW7647
Packaging: 5mg
Price: $378
Updated: 2024/03/01

Cayman Chemical

Product number: 10008613
Product name: GW 7647
Purity: ≥98%
Packaging: 1mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 10008613
Product name: GW 7647
Purity: ≥98%
Packaging: 5mg
Price: $142
Updated: 2024/03/01

Sigma-Aldrich

Product number: G6793
Product name: GW7647
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $571.8
Updated: 2024/03/01

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GW7647 Chemical Properties,Usage,Production

Description

Peroxisome proliferator-activated receptor-α (PPARα) is a ligand-activated transcription factor involved in the regulation of lipid homeostasis. Activation of PPARα results in expression of a variety of genes, particularly those involved in fatty acid β-oxidation, binding, and transport. GW 7647 is a potent, selective agonist of human and murine PPARα It activates human PPARα, PPARγ, and PPARδ with EC₅₀ values of 0.006, 1.1 and 6.2 μM, respectively, in a GAL4-PPAR binding assay. Similar EC₅₀ values of 0.001, 1.3, and 2.9 were observed with the murine receptors. GW 7647 lowered triglycerides 93% and 60% in fat-fed hamsters and rats, respectively, at a dose of 3 mg/kg.

Uses

GW7647 has been used as a peroxisome proliferator-activated receptor α (PPAR α) ligand:

in defatting medium to treat primary human hepatocytes
to test its effect on the glycolytic function in cardiomyocytes
to test its effect on infant mouse heart
in breast cancer MDA-MB-231 cells to activate PPARs

Uses

GW 7647 is a potent PPARα agonist with 200-fold selectivity over PPARγ and PPARδ. It can also be used for regenerative cardiac cell therapies.

Definition

ChEBI: A monocarboxylic acid that is 2-(phenylsulfanyl)isobutyric acid in which the phenyl group is substituted at the para- position by a 3-aza-7-cyclohexylhept-1-yl group in which the nitrogen is acylated by a (cyclohexylamino)carbonyl group.

General Description

A cell-permeable urea-substituted thioisobutyric acid (ureido-TiBA) compound that acts as a potent and selective PPARα agonist (PPARα, γ and δ - EC₅₀ = 6 nM, 1.1 μM and 6.2 μM for human; 1 nM, 1.3 μM and 2.9 μM for murine, respectively). Also displays in vivo lipid-lowering activity in rats.

Biological Activity

Potent and highly selective PPAR α agonist (EC 50 values are 6, 1100 and 6200 nM for human PPAR α , PPAR γ and PPAR δ receptors respectively). Modulates oleate metabolism and mitochondrial enzyme gene expression in mature myotubules in vitro . Has lipid-lowering effects following oral administration in vivo .

Biochem/physiol Actions

GW7647 reduces serum triglyceride levels and enhances hepatic expression of genes associated with β-oxidation. Usage of GW7647 along with metformin in conditions of liver steatosis or injury improves the enzymatic levels of aspartate transaminase (AST) and alanine transaminase (ALT) in serum.

storage

Store at RT

GW7647 Preparation Products And Raw materials

Raw materials

Preparation Products

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265129-71-3, GW7647Related Search:

Methylcyclohexane 2-[(4-METHYLPHENYL)THIO]PROPANOIC ACID GW7647

GW647

GW7647

2-(4-(2-(1-CYCLOHEXANEBUTYL)-3-CYCLOHEXYLUREIDO)ETHYL)PHENYLTHIO)-2-METHYLPROPIONIC ACID

2-[[4-[2-[[(CYCLOHEXYLAMINO)CARBONYL](4-CYCLOHEXYLBUTYL)AMINO]ETHYL]PHENYL]THIO]-2-METHYLPROPANOIC ACID

2-((4-(2-(((Cyclohexylamino)carbonyl)-(4-cyclohexylbutyl)amino)ethyl)phenyl)thio)-2-methylpropanoicacid

GW 7647X

GWalpha 7647

Propanoic acid, 2-[[4-[2-[[(cyclohexylaMino)carbonyl](4-cyclohexylbutyl)aMino]ethyl]phenyl]thio]-2-Methyl-

GW7647, >=98%

GW7647 - CAS 265129-71-3 - Calbiochem

CS-761

GW7647; GW 7647

2-[[4-[2-[[(Cyclohexylamino)carbonyl](4-cyclohexylbutyl)amino]ethyl]phenyl]thio]-2-methylpropa

2-((4-(2-(3-Cyclohexyl-1-(4-cyclohexylbutyl)ureido)ethyl)phenyl)thio)-2-methylpropanoic acid

GW7647, PPARalpha agonist

265129-71-3

C29H46N2O3S

BioChemical

Cell Biology

Cell Signaling and Neuroscience

PPAR and RXR Regulators

Gene Regulation and Expression

Intracellular receptor