ABACAVIR SULFATE

Product Name: ABACAVIR SULFATE
CAS No.: 136777-48-5
Chemical Name: ABACAVIR SULFATE
Synonyms: ZIAGEN;ABACAVIR SULPHATE;Abacavir (hydrochloride);Abacavir & Abacavir Sulfate;((1S,4R)-4-(2-amino-6-(cyclopropylamino)-9H-purin-9-yl)cyclopent-2-enyl)methano;(4S)-4-[2-amino-6-(cyclopropylamino)purin-9-yl]cyclopenten-1-yl]methanol,sulfuricaci;(1S-cis)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol monohydrochloride
CBNumber: CB5425547
Molecular Formula: C14H19ClN6O
Formula Weight: 322.8
MOL File: 136777-48-5.mol

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: A105048
Product name: AbacavirSulphate
Packaging: 1mg
Price: $60
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CCH0005937
Product name: 4R-(2-AMINO-6-(CYCLOPROPYLAMINO)-9H-PURIN-9-YL)-2-CYCLOPENTENE-1S-METHANOL, MONOHYDROCHLORIDE
Purity: 95.00%
Packaging: 1G
Price: $181.65
Updated: 2021/12/16

AK Scientific

Product number: V2105
Product name: Abacavirsulphate
Packaging: 100mg
Price: $210
Updated: 2021/12/16

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ABACAVIR SULFATE Chemical Properties,Usage,Production

Uses

Abacavir hydrochloride is a competitive, orally active nucleoside reverse transcriptase inhibitor. Abacavir hydrochloride can inhibits the replication of HIV. Abacavir hydrochloride shows anticancer activity in prostate cancer cell lines. Abacavir hydrochloride can trespass the blood-brain-barrier and suppresses telomerase activity[1][2][3].

Definition

ChEBI: Abacavir sulfate is an azaheterocycle sulfate salt that is the sulfate salt of the HIV-1 reverse transcriptase inhibitor abacavir. It is functionally related to an abacavir.

in vivo

Abacavir hydrochloride (100 and 200 mg/kg, p.o.; 4 h) dose-dependently promotes thrombus formation^[2].
Abacavir hydrochloride (50 mg/kg/d; i.p.; 14 d) with 0.1 mg/kg/d Decitabine.html" class="link-product" target="_blank">Decitabine (HY-A0004) enhances survival of high-risk medulloblastoma-bearing mice^[3].

Animal Model:	Male mice (9-weeks old, 22-30 g) - wild-type (WT) C57BL/6 or homozygous knockout (P2rx7 KO, B6.129P2-P2rx7^tm1Gab/J)^[2]
Dosage:	Route 1: 2.5, 5, and 7.5 μg/mL, 100 μL Route 2: 100 and 200 mg/kg
Administration:	Intrascrotal or oral administration for 4 h
Result:	Dose-dependently promoted thrombus formation.

Animal Model:	NSG^TM mice, patient-derived xenograft (PDX) cells of non-WNT/non-SHH, Group 3 and of SHH/ TP53-mutated medulloblastoma^[3]
Dosage:	50 mg/kg/d with 0.1 mg/kg/d Decitabine
Administration:	Intraperitoneal injection, daily for 14 days
Result:	Inhibited tumor growth and enhanced mouse survival.

References

[1] Carlini F, et al. The reverse transcription inhibitor abacavir shows anticancer activity in prostate cancer cell lines. PLoS One. 2010 Dec 3;5(12):e14221. DOI:10.1371/journal.pone.0014221
[2] Collado-Diaz V, et al. Abacavir Induces Arterial Thrombosis in a Murine Model. J Infect Dis. 2018 Jun 20;218(2):228-233. DOI:10.1093/infdis/jiy001
[3] Gringmuth M, et al. Enhanced Survival of High-Risk Medulloblastoma-Bearing Mice after Multimodal Treatment with Radiotherapy, Decitabine, and Abacavir. Int J Mol Sci. 2022 Mar 30;23(7):3815. DOI:10.3390/ijms23073815
[4] McComsey GA, et al. Improvements in lipoatrophy, mitochondrial DNA levels and fat apoptosis after replacing stavudine with abacavir or zidovudine. AIDS. 2005 Jan 3;19(1):15-23. DOI:10.1097/00002030-200501030-00002

ABACAVIR SULFATE Preparation Products And Raw materials

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ABACAVIR SULFATE Suppliers

China 19 Europe 2 Germany 1 India 4 United Kingdom 2 United States 3 Global 31

Hangzhou Yuhao Chemical Technology Co., Ltd

Tel: 0571-82693216
Fax: +86-571-82880190
Email: info@yuhaochemical.com
Country: China
ProdList: 6387
Advantage: 52

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Hefei TNJ Chemical Industry Co.,Ltd.

Tel: +86-0551-65418684 +8618949823763
Fax: 0086-551-65418684
Email: sales@tnjchem.com
Country: China
ProdList: 25356
Advantage: 58

Dideu Industries Group Limited

Tel: +86-29-89586680 +86-15129568250
Email: 1026@dideu.com
Country: China
ProdList: 20284
Advantage: 58

AFINE CHEMICALS LIMITED

Tel: +86-0571-85134551
Fax: 008657185134895
Email: sales@afinechem.com
Country: China
ProdList: 15109
Advantage: 58

Beijing Qinling Pharmaceutical Co., Ltd.

Tel: 010-61241352 18901327973
Email: 834537306@qq.com
Country: China
ProdList: 5860
Advantage: 58

Pushan Industry (Shaanxi) Co., Ltd.

Tel: 029-81310890 13571859809
Email: info@pushanshiye.com
Country: China
ProdList: 9953
Advantage: 58

Shanghai Beiwanta Biotechnology Co., Ltd.

Tel: 021-67187366 19901745723
Email: info@bwtlab.com
Country: China
ProdList: 9650
Advantage: 58

SHANGHAI ZZBIO CO., LTD.

Tel: 15102117276 19921389125
Email: tech@zzbioco.com
Country: China
ProdList: 12064
Advantage: 58

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View Lastest Price from ABACAVIR SULFATE manufacturers

Dideu Industries Group Limited

Product: ABACAVIR SULFATE 136777-48-5
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons Min
Release date: 2021-07-15

136777-48-5, ABACAVIR SULFATERelated Search:

Abacavir ABACAVIR SULFATE ABACAVIR SULFATE 2,6-DIAMINOPURINE SULPHATE MONOHYDRATE Adenine Sulfate 2,6-DIAMINOPURINE SULFATE (1S-cis)-4-Amino-2-cyclopentene-1-methanol

ABACAVIR SULPHATE

((1S,4R)-4-(2-amino-6-(cyclopropylamino)-9H-purin-9-yl)cyclopent-2-enyl)methano

Abacavir & Abacavir Sulfate

Abacavir (hydrochloride)

(1S-cis)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol monohydrochloride

ZIAGEN

(4S)-4-[2-amino-6-(cyclopropylamino)purin-9-yl]cyclopenten-1-yl]methanol,sulfuricaci

136777-48-5

C14H18N6OHCl