(S)-(-)-4-ISOBUTYLOXAZOLIDINE-2,5-DIONE

Product Name: (S)-(-)-4-ISOBUTYLOXAZOLIDINE-2,5-DIONE
CAS No.: 3190-70-3
Chemical Name: (S)-(-)-4-ISOBUTYLOXAZOLIDINE-2,5-DIONE
Synonyms: Leu-NCA;L-Leu-NCA;L-Leucine NCA;L-Leucine N-Carboxanhydride;L-Leucine N-carboxyanhydride;N-Carboxy-L-leucine anhydride;(4S)-4-Isobutyloxazolidine-2,5-dione;(S)-4-ISOBUTYL-OXAZOLIDINE-2,5-DIONE;(S)-(-)-4-ISOBUTYLOXAZOLIDINE-2,5-DIONE;(4S)-4-Isobutyl-1,3-oxazolidine-2,5-dione
CBNumber: CB5427213
Molecular Formula: C7H11NO3
Formula Weight: 157.17
MOL File: 3190-70-3.mol

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(S)-(-)-4-ISOBUTYLOXAZOLIDINE-2,5-DIONE Property

Melting point:: 76-77°C
Density: 1.124±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
pka: 9.38±0.40(Predicted)
Appearance: White to off-white Solid
optical activity: Consistent with structure

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Safety

Safety Statements: 22-24/25
HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TRC

Product number: C178575
Product name: N-CarboxyleucineAnhydride
Packaging: 5g
Price: $860
Updated: 2021/12/16

AK Scientific

Product number: 3505AB
Product name: (S)-4-Isobutyloxazolidine-2,5-dione
Packaging: 10g
Price: $266
Updated: 2021/12/16

Apolloscientific

Product number: OR480785
Product name: (4S)-4-Isobutyloxazolidine-2,5-dione
Purity: 95%
Packaging: 5g
Price: $383
Updated: 2021/12/16

ChemScene

Product number: CS-0031376
Product name: L-LeucineNCA
Purity: ≥97.0%
Packaging: 1g
Price: $26
Updated: 2021/12/16

Activate Scientific

Product number: AS42079
Product name: (S)-4-Isobutyloxazolidine-2,5-dione
Purity: 95+% ee
Packaging: 1g
Price: $68
Updated: 2021/12/16

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(S)-(-)-4-ISOBUTYLOXAZOLIDINE-2,5-DIONE Chemical Properties,Usage,Production

Uses

N-Carboxyleucine Anhydride is a reagent in the synthesis of hybrid polypeptide micelles which are used to load indocyanine green dyes into lab rats for tumor imaging and photothermal effect studies.

Synthesis

75-44-5

61-90-5

3190-70-3

General procedure for the synthesis of (S)-4-isobutyloxazolidine-2,5-dione from phosgene and L-leucine: L-leucine amide (HO-Leu-NH2, 10.0 g, 76.2 mmol) was suspended in 150 mL of anhydrous tetrahydrofuran (THF), and heated to 50 °C. A 20% phosgene solution of toluene (76.0 mL, 152.4 mmol) was slowly added to the amino acid suspension. After about 1 hour, the amino acids were completely dissolved to form a clarified solution. The reaction solution was concentrated on a rotary evaporator, transferred to a beaker, and the product was precipitated by the addition of hexane. The white solid was separated by filtration and dissolved in toluene. The toluene solution was filtered through a bed of diatomaceous earth to remove insoluble impurities. Excess hexane was added to the filtrate to precipitate the product again. N-carboxy-L-leucine anhydride (Leu NCA) was obtained by filtration separation and dried under vacuum. 9.0 g (75% yield) of Leu NCA was finally obtained as a white crystalline solid. Its 1H NMR (d6-DMSO) data were as follows: δ 9.13 (1H), 4.44 (1H), 1.74 (1H), 1.55 (2H), 0.90 (6H) ppm.

References

[1] Advanced Synthesis and Catalysis, 2004, vol. 346, # 9-10, p. 1247 - 1249
[2] Patent: US2008/274173, 2008, A1. Location in patent: Page/Page column 94
[3] Journal of the Chemical Society, 1950, p. 3222,3225
[4] Patent: US2789973, 1950,
[5] Nippon Kagaku Zasshi, 1956, vol. 77, p. 44,46

(S)-(-)-4-ISOBUTYLOXAZOLIDINE-2,5-DIONE Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-(-)-4-ISOBUTYLOXAZOLIDINE-2,5-DIONE Suppliers

China 73 Germany 2 India 2 United Kingdom 2 United States 8 Global 87

J & K SCIENTIFIC LTD.

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View Lastest Price from (S)-(-)-4-ISOBUTYLOXAZOLIDINE-2,5-DIONE manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: L-Leu-NCA 3190-70-3
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1T+
Release date: 2024-01-18

Shaanxi Dideu Medichem Co. Ltd

Product: (S)-(-)-4-ISOBUTYLOXAZOLIDINE-2,5-DIONE 3190-70-3
Price: US $1.00/Kg
Min. Order: 1Kg
Purity: 98%
Supply Ability: 20T
Release date: 2024-07-09

Career Henan Chemical Co

Product: (S)-(-)-4-ISOBUTYLOXAZOLIDINE-2,5-DIONE 3190-70-3
Price: US $1.00/g
Min. Order: 1g
Purity: 99.0%
Supply Ability: 100 kg
Release date: 2020-01-10

3190-70-3, (S)-(-)-4-ISOBUTYLOXAZOLIDINE-2,5-DIONERelated Search:

4-isobutyloxazolidine-2,5-dione (S)-4-Isobutyl-2-Oxazolidinone DL-4-ISOBUTYLOXAZOLIDINE-2,5-DIONE,(R,S)-4-ISOBUTYLOXAZOLIDINE-2,5-DIONE NALPHA-9-Fluorenylmethoxycarbonyl-L-leucine N-carboxylic anhydride Z-L-Leucine N-carboxyanhydride N-tert-Butoxycarbonyl-L-leucine N-carboxylic anhydride (S)-(-)-4-ISOBUTYLOXAZOLIDINE-2,5-DIONE

(S)-(-)-4-ISOBUTYLOXAZOLIDINE-2,5-DIONE

(S)-4-ISOBUTYL-OXAZOLIDINE-2,5-DIONE

(4S)-4β-(2-Methylpropyl)oxazolidine-2,5-dione

(S)-4β-(2-Methylpropyl)-2,5-oxazolidinedione

L-Leucine NCA

N-Carboxy-L-leucine anhydride

L-Leu-NCA

L-Leucine N-carboxyanhydride

Leu-NCA

(4S)-4-Isobutyloxazolidine-2,5-dione

(S)-4-Isobutyloxazolidine-2,5-dione(S)-4-Isobutyloxazolidine-2,5-dione

L-Leucine N-Carboxanhydride

2,5-Oxazolidinedione, 4-(2-methylpropyl)-, (4S)-

4-(2-methylpropyl)-1,3-oxazolidine-2,5-dione

(4S)-4-Isobutyl-1,3-oxazolidine-2,5-dione

(4S)-4-(2-methylpropyl)-1,3-oxazolidine-2,5-dione

3190-70-3

190-70-3