FMOC-N-(N-BETA-BOC-AMINOETHYL)-GLY-OH

Product Name: FMOC-N-(N-BETA-BOC-AMINOETHYL)-GLY-OH
CAS No.: 141743-15-9
Chemical Name: FMOC-N-(N-BETA-BOC-AMINOETHYL)-GLY-OH
Synonyms: FMOC-AEG-OH;FMOC-AEG(BOC)-OH;FMOC-BOCNHETGLY-OH;Fmoc-N-(2-Boc-aminoethyl)-Gly-OH;FMOC-N-(2-BOC-AMINOETHYL)-GLYCINE;Fmoc-N-(N-a-Boc-aminoethyl)-Gly-OH;Fmoc-N-(N-β-Boc-aminoethyl)-Gly-OH;FMoc-N-(N-b-Boc-aMinoethyl)-Gly-OH;FMOC-N-(N-BETA-BOC-AMINOETHYL)-GLY-OH;FMOC-N-(N-BETA-BOC-AMINOETHYL)-GLYCINE
CBNumber: CB5428715
Molecular Formula: C24H28N2O6
Formula Weight: 440.49
MOL File: 141743-15-9.mol

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FMOC-N-(N-BETA-BOC-AMINOETHYL)-GLY-OH Property

Boiling point:: 638.3±48.0 °C(Predicted)
Density: 1.250±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
pka: 3.85±0.10(Predicted)

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Safety

Hazard Codes: N
Risk Statements: 50/53
Safety Statements: 60-61
RIDADR: UN 3077 9/PG 3
WGK Germany: 3
HS Code: 29242990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: F604393
Product name: Fmoc-N-(2-Boc-aminoethyl)-Gly-OH
Packaging: 500mg
Price: $285
Updated: 2021/12/16

Iris Biotech GmbH

Product number: FAA1767
Product name: Fmoc-Aeg(Boc)-OH
Packaging: 1g
Price: $168.75
Updated: 2021/12/16

Activate Scientific

Product number: AS86257
Product name: Fmoc-N-(2-Boc-aminoethyl)glycine
Purity: 95+%
Packaging: 5G
Price: $774
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: AAA0003858
Product name: FMOC-N-(2-BOC-AMINOETHYL)-GLY-OH
Purity: 95.00%
Packaging: 1G
Price: $848.93
Updated: 2021/12/16

Chem-Impex

Product number: 11190
Product name: Fmoc-N-(2-Boc-aminoethyl)glycine,99%(HPLC)
Purity: 99%(HPLC)
Packaging: 5G
Price: $1310.4
Updated: 2021/12/16

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FMOC-N-(N-BETA-BOC-AMINOETHYL)-GLY-OH Chemical Properties,Usage,Production

Chemical Properties

White crystalline powder

Uses

Fmoc-N-(2-Boc-aminoethyl)-Gly-OH is a Fmoc-protected glycine derivative that can be used in antibody agent coupling (ADC) synthesis. ADC consists of antibodies that are linked to ADC cytotoxins via ADC junctions[1].

Synthesis

82911-69-1

90495-99-1

141743-15-9

The general procedure for the synthesis of Fmoc-N-(2-Boc-aminoethyl)glycine from 9-fluorenylmethyl-N-succinimidyl carbonate and 2-((2-((tert-butoxycarbonyl)amino)ethyl)amino)acetic acid was as follows: 10.9 g (50 mmol) of 2-((2-((tert-butoxycarbonyl)amino)ethyl)amino)acetic acid was mixed and stirred with 50 mL of water, adding 11.3 g (135 mmol) sodium bicarbonate and 50 mL of tetrahydrofuran. Subsequently, 24.3 g (72 mmol) of 9-fluorenylmethyl-N-succinimidyl carbonate was added. The reaction mixture was stirred at room temperature for 20 h. After completion of the reaction, the resulting salt was removed by filtration. The filtrate was acidified to separate the phases and the organic phase was subsequently concentrated to afford the product N-(2-tert-butoxycarbonylaminoethyl)-N-(9-fluorenylmethoxycarbonyl)aminoacetic acid in 21.0 g (99%) yield.

References

[1] Hiroyuki Naito, et al. (anti-her2 antibody)-drug conjugate. EP3130608

FMOC-N-(N-BETA-BOC-AMINOETHYL)-GLY-OH Preparation Products And Raw materials

Raw materials

Preparation Products

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FMOC-N-(N-BETA-BOC-AMINOETHYL)-GLY-OH Suppliers

China 53 France 1 Germany 2 India 1 Japan 1 Switzerland 1 United States 7 Global 66

J & K SCIENTIFIC LTD.

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Shanghai GL Peptide Ltd.

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141743-15-9, FMOC-N-(N-BETA-BOC-AMINOETHYL)-GLY-OHRelated Search:

4-Boc-1-Fmoc-2-piperazinecarboxylic acid (R,S)-N-FMOC-N'-BOC-IMIDAZOLIDINE-2-CARBOXYLIC ACID (2S, 4S)-BOC-4-AMINO-1-FMOC-PYRROLIDINE-2-CARBOXYLIC ACID (2S, 4R)-BOC-4-AMINO-1-FMOC-PYRROLIDINE-2-CARBOXYLIC ACID (S)-1-(((9H-FLUOREN-9-YL)METHOXY)CARBONYL)-4-(TERT-BUTOXYCARBONYL)PIPERAZINE-2-CARBOXYLIC ACID (2S5R)-N-ALPHA-9-FLUORENYLMETHYLOXYCARBONYL-PYRROLIDINE-5-(N'-T-BUTYLOXYCARBONYL-AMINOMETHYL)-2-CARBOXYLIC ACID (R)-1-(((9H-FLUOREN-9-YL)METHOXY)CARBONYL)-4-(TERT-BUTOXYCARBONYL)PIPERAZINE-2-CARBOXYLIC ACID FMOC-N-(N-BETA-BOC-AMINOETHYL)-GLY-OH

Fmoc-N-(2-Boc-aminoethyl)glycine≥ 99% (HPLC)

N-(9-FLUORENYLMETHOXYCARBONYL)-N-(2-TERT-BUTYLOXYCARBONYLAMINO-ETHYL)-GLYCINE

N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-N-(BETA-T-BUTOXYCARBONYLAMINOETHYL)-GLYCINE

FMOC-AEG(BOC)-OH

FMOC-AEG-OH

FMOC-BOCNHETGLY-OH

FMOC-N-(2-BOC-AMINOETHYL)-GLYCINE

FMOC-N-(N-BETA-BOC-AMINOETHYL)-GLYCINE

FMOC-N-(N-BETA-BOC-AMINOETHYL)-GLY-OH

(9H-Fluoren-9-yl)MethOxy]Carbonyl N-(2-(Tert-Butoxy)Carbonyl aminoethyl)-Gly-OH

2-[9H-fluoren-9-ylmethoxycarbonyl-[2-[(2-methylpropan-2-yl)oxycarbonylamino]ethyl]amino]acetic acid

N-(9-FLUORENYLMETHYLOXYCARBONYL)-N-(2-T-BUTYLOXYCARBONYLAMINO-ETHYL)-GLYCINE

N-(9-FLUOROENYLMETHYLOXYCARBONYL)-N-(2-T-BUTYLOXYCARBONYLAMINO-ETHYL)-GLYCINE

Fmoc-N-(N-a-Boc-aminoethyl)-Gly-OH

Fmoc-N-(2-Boc-aminoethyl)-Gly-OH

Fmoc-N-(N-β-Boc-aminoethyl)-Gly-OH

FMoc-N-(N-b-Boc-aMinoethyl)-Gly-OH

Glycine,N-[2-[[(1,1-dimethylethoxy)carbonyl]amino]ethyl]-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-

2-[(2-{[(tert-butoxy)carbonyl]amino}ethyl)({[(9H-fluoren-9-yl)methoxy]carbonyl})amino]acetic acid

[(2-{[(tert-butoxy)carbonyl]amino}ethyl)[(9H-fluoren-9-ylmethoxy)carbonyl]amino]acetic acid

141743-15-9