N-(1,5-dimethyl-3-oxo-2-phenylpyrazol-4-yl)-3-methyl-1-phenylthieno[2,3-c]pyrazole-5-carboxamide
- Product Name
- N-(1,5-dimethyl-3-oxo-2-phenylpyrazol-4-yl)-3-methyl-1-phenylthieno[2,3-c]pyrazole-5-carboxamide
- CAS No.
- 306959-01-3
- Chemical Name
- N-(1,5-dimethyl-3-oxo-2-phenylpyrazol-4-yl)-3-methyl-1-phenylthieno[2,3-c]pyrazole-5-carboxamide
- Synonyms
- MYLS22;OPA1,Inhibitor,MYLS22,optic,atrophy,endothelial,MYLS-22,inhibit,MYLS 22,tumor;N-(1,5-dimethyl-3-oxo-2-phenylpyrazol-4-yl)-3-methyl-1-phenylthieno[2,3-c]pyrazole-5-carboxamide;N-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-3-methyl-1-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxamide;1H-Thieno[2,3-c]pyrazole-5-carboxamide, N-(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)-3-methyl-1-phenyl-
- CBNumber
- CB54362408
- Molecular Formula
- C24H21N5O2S
- Formula Weight
- 443.52
- MOL File
- 306959-01-3.mol
N-(1,5-dimethyl-3-oxo-2-phenylpyrazol-4-yl)-3-methyl-1-phenylthieno[2,3-c]pyrazole-5-carboxamide Property
- storage temp.
- Store at -20°C
- solubility
- DMSO: 83.33 mg/mL (187.88 mM)
- form
- Solid
- color
- Off-white to yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H226Flammable liquid and vapour
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P240Ground/bond container and receiving equipment.
P241Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242Use only non-sparking tools.
P243Take precautionary measures against static discharge.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P363Wash contaminated clothing before reuse.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- L344575
- Product name
- N-(1,5-DIMETHYL-3-OXO-2-PHENYL-2,3-DIHYDRO-1H-PYRAZOL-4-YL)-3-METHYL-1-PHENYL-1H-THIENO[2,3-C]PYRAZOLE-5-CARBOXAMIDE
- Purity
- AldrichCPR
- Packaging
- 10MG
- Price
- $29.8
- Updated
- 2024/03/01
- Product number
- A1097751
- Product name
- N-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-3-methyl-1-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxamide
- Purity
- 95%
- Packaging
- 25mg
- Price
- $247
- Updated
- 2021/12/16
- Product number
- A1097751
- Product name
- N-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-3-methyl-1-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxamide
- Purity
- 95%
- Packaging
- 50mg
- Price
- $345
- Updated
- 2021/12/16
N-(1,5-dimethyl-3-oxo-2-phenylpyrazol-4-yl)-3-methyl-1-phenylthieno[2,3-c]pyrazole-5-carboxamide Chemical Properties,Usage,Production
Biological Activity
MYLS22 is a first-in-class, selective optic atrophy 1 (OPA1) inhibitor. It can target endothelial cell OPA1 to reduce tumor growth and inhibit angiogenesis by affecting NFkB activity and angiogenic gene expression.
in vivo
MYLS22 (10 mg/kg/die; peritumoral injection; every 2 days for 14 days) causes the tumor growth curtailed mice.
| Animal Model: | 6-week-old C57BL6/J mice with B16F10 melanomas |
| Dosage: | 10 mg/kg/die |
| Administration: | Peritumoral injection; every 2 days for 14 days |
| Result: | Caused the tumor growth curtailed. |
target
OPA1
N-(1,5-dimethyl-3-oxo-2-phenylpyrazol-4-yl)-3-methyl-1-phenylthieno[2,3-c]pyrazole-5-carboxamide Preparation Products And Raw materials
Raw materials
Preparation Products
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