ChemicalBook > CAS DataBase List > MSIRK
MSIRK
- Product Name
- MSIRK
- CAS No.
- 593267-11-9
- Chemical Name
- MSIRK
- Synonyms
- MSIRK;MYR-SIRKALNILGYPDYD-OH;L-Aspartic acid, N-(1-oxotetradecyl)-L-seryl-L-isoleucyl-L-arginyl-L-lysyl-L-alanyl-L-leucyl-L-asparaginyl-L-isoleucyl-L-leucylglycyl-L-tyrosyl-L-prolyl-L-α-aspartyl-L-tyrosyl-
- CBNumber
- CB5438561
- Molecular Formula
- C93H150N20O25
- Formula Weight
- 1948.31
- MOL File
- Mol file
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MSIRK Property
- Density
- 1.368±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
- pka
- 2.837±0.10(predicted)
- form
- Solid
- color
- White to off-white
- Sequence
- {Myr}-Ser-Ile-Arg-Lys-Ala-Leu-Asn-Ile-Leu-Gly-Tyr-Pro-Asp-Tyr-Asp
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MSIRK Chemical Properties,Usage,Production
Uses
mSIRK (G-Protein βγ Binding Peptide) is an cell-permeable activator of ERK1/2, with EC50 of 2.5-5 μM. mSIRK disrupts the interaction between α and βγ subunits and promotes α subunit dissociation without stimulating nucleotide exchange[1].
References
[1] Farida Goubaeva, et al. Stimulation of Cellular Signaling and G Protein Subunit Dissociation by G Protein βγ Subunit-binding Peptides. J Biol Chem. 2003 May 30;278(22):19634-41. DOI:10.1074/jbc.M300052200
MSIRK Preparation Products And Raw materials
Raw materials
Preparation Products
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