Josamycin

ChemicalBook > CAS DataBase List > Josamycin

Product Name: Josamycin
CAS No.: 16846-24-5
Chemical Name: Josamycin
Synonyms: C12662;EN 141;Jomybel;YL-704A3;Iosalide;Josacine;Josamina;Wilprafen;Vilprafen;JOSAMYCIN
CBNumber: CB5444692
Molecular Formula: C42H69NO15
Formula Weight: 827.99
MOL File: 16846-24-5.mol

Less

Josamycin Property

Melting point:: 131.5℃
alpha: D25 -70° (c = 1 in ethanol)
Boiling point:: 763.27°C (rough estimate)
Density: 1.1547 (rough estimate)
refractive index: 1.6220 (estimate)
storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: Soluble in ethanol
form: powder
pka: 7.1 (40% aq methanol)
color: white to slightly yellow
Merck: 13,5286
Stability:: Hygroscopic

Less

Safety

WGK Germany: 2
RTECS: OH4725810
F: 10
Toxicity: LD50 oral in rat: > 7gm/kg

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: Y0000041
Product name: Josamycin
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: y0000041
Price: $220
Updated: 2024/03/01

Sigma-Aldrich

Product number: 59983
Product name: Josamycin
Purity: ≥98.0% (UV)
Packaging: 50mg
Price: $65.8
Updated: 2024/03/01

Alfa Aesar

Product number: J62245
Product name: Josamycin, 98+%
Packaging: 50mg
Price: $93.65
Updated: 2024/03/01

Cayman Chemical

Product number: 29606
Product name: Josamycin
Packaging: 50mg
Price: $53
Updated: 2024/03/01

Cayman Chemical

Product number: 29606
Product name: Josamycin
Packaging: 100mg
Price: $93
Updated: 2024/03/01

Less

Josamycin Chemical Properties,Usage,Production

Chemical Properties

Josamycin is a macrolide substance having antibacterial activity produced by the growth of Streptomyces narboensis var. josamyceticus.
Josamycin appears as white to yellowish white powder, slightly hygroscopic. Josamycin is very soluble in methanol or in ethanol, and very slightly soluble in water.

Originator

Josalid,Biochemie

Uses

Josamycin, is used as a macrolide antibiotic effective against a variety of pathogens.

Uses

As a 16-membered ring macrolide antibiotic with antimicrobial activity against a wide range of pathogens. Josamycin can be particularly used in the treatment of Mycoplasma infection.
Josamycin is used to study the modification of phagocytosis and cytokine production by macrolide antibiotics, immunomodulatory effects, the suppression of matrix metalloproteinase production as well as study bacteria protein synthesis at the level of the the 23S rRNA, 50S ribosomal subunit.

Definition

ChEBI: A macrolide antibiotic produced by certain strains of Streptomyces narbonensis var. josamyceticus.

Manufacturing Process

100 ml of a culture medium consisting of water containing 1.5% soybean meal, 1% starch, 1% glucose, 0.3% sodium chloride, 0.1% dipotassium hydrogen phosphate, and 0.05% magnesium sulfate was placed in a 500 ml flask and sterilized for 20 min at 120°C. After cooling, the culture medium was inoculated with strain A 205-P2 Streptomyces narbonensis var. josatny ceticus, and the strain was subjected to shaking culture at 27°-29°C and at 130 strokes per min and 8 cm amplitude. After 3 days of culture, the culture fluids in such 100 flasks were combined together and filtered to give 8700 ml of culture filtrate. The pH of the filtrate was 6.4 and showed an inhibition zone of 25 mm. to Bacillus subtilis (PCI 219 strain). The filtrate was extracted with 8700 ml of ethyl acetate. The extract (7300 ml) thus obtained was concentrated to 730 ml under vacuum at temperatures lower than 50°C, 360 ml of water added, and then concentrated hydrochloric acid added to ad just the pH to 2.0, whereby josamycin was transferred to the aqueous layer. After adjusting the pH of the aqueous layer to 7.5 by the addition of 0.1 N sodium hydroxide, josamycin was extracted with 180 ml of ethyl acetate.
Josamycin was then transferred to 90 ml of an aqueous solution at pH 2.0 and extracted again with 45 ml of ethyl acetate as above process. Ethyl acetate solution thus obtained was evaporated under reduced pressure to give a solidified product, which was dissolved in 5 ml of benzene to remove impurities and the product, solidified from the benzene solution by evaporating under reduced pressure, was dissolved in a small amount of ethyl acetate and subjected to an alumina chromatography. That is, Brockman alumina (Merck) was treated with hydrochloric acid, sufficiently rinsed with water, and activated by heating for 5 h at 150°C.
50.0 g of thus treated alumina was filled in a glass tube of 1.6 cm in diameter by using ethyl acetate. The above prepared ethyl acetate solution was added to the alumina column and the product was eluted with 200 ml of ethyl acetate. The eluate thus obtained was concentrated under reduced pressure and the solid product thus obtained was dissolved in 5 ml of benzene and 50 ml of n-hexane added to give 0.18 g of amorphous josamycin having a purity of above 90%.

Therapeutic Function

Antibiotic

Pharmaceutical Applications

A naturally occurring antibiotic produced by Streptomyces narbonensis var. josamyceticus and belonging to the leucomycin group of macrolides. It is formulated for oral administration.
Many Gram-positive and Gram-negative anaerobes are susceptible, including Peptostreptococcus spp., Propionibacterium spp., Eubacterium spp. and Bacteroides spp.
After a single 1 g oral dose, a peak serum concentration of 2.74 mg/L was achieved 0.75 h after dosing. The AUC was 4.2 mg.h/L, and the apparent elimination half-life 1.5 h. Several inactive metabolites could be detected. It penetrates into saliva, tears and sweat, and achieves high levels in bile and lungs. It is mostly metabolized and excreted in the bile in an inactive form. Less than 20% of the dose appears in the urine, producing levels of around 50 mg/L.
The drug is generally well tolerated, producing only mild gastrointestinal disturbance. Its uses are similar to those of erythromycin. It is of limited availability.

Biological Activity

Josamycin inhibits bacterial protein biosynthesis by inhibiting peptidyltransferase and ribosomal translocation, and depleting the intracellular pools of aminoacyl-tRNAs available for protein synthesis by drop-off and incomplete peptidyl-tRNA hydrolase activity. It slows down formation of the first peptide bond of a nascent peptide in an amino acid-dependent way and inhibits formation of the second or third peptide bond.

Josamycin Preparation Products And Raw materials

Raw materials

Preparation Products

Less

Josamycin Suppliers

Belgium 1 Canada 2 China 168 France 2 Germany 7 India 4 Japan 4 Switzerland 5 The Netherlands 1 United Kingdom 6 United States 25 Global 225

Wellman Pharmaceutical Group Limited

Tel: 027-027-83778875 15807197853
Fax: 027-83991220
Email: 15807197853@163.com
Country: China
ProdList: 3981
Advantage: 58

Hubei wei shi reagent group ltd., company

Tel: 027-59105166 13125137732
Email: 2853863890@qq.com
Country: China
ProdList: 2978
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32344
Advantage: 50

Beijing HuaMeiHuLiBiological Chemical

Tel: 010-56205725
Fax: 010-65763397
Email: waley188@sohu.com
Country: China
ProdList: 12338
Advantage: 58

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-400-6206333 18521732826
Fax: 021-50323701
Email: market@aladdin-e.com
Country: China
ProdList: 25014
Advantage: 65

Shanghai Ruji Biology Technology Co., Ltd.

Tel: +86-21-65211385-8001 36031160
Fax: +86-21-65211385-8004
Email: sales@shruji.com
Country: China
ProdList: 3224
Advantage: 55

Guangzhou Isun Pharmaceutical Co., Ltd

Tel: 020-39119399 18927568969
Fax: 020-39119999
Email: isunpharm@qq.com
Country: China
ProdList: 4428
Advantage: 55

Nanjing Sunlida Biological Technology Co., Ltd.

Tel: 025-57798810
Fax: 025-57019371
Email: sales@sunlidabio.com
Country: China
ProdList: 3750
Advantage: 55

TargetMol Chemicals Inc.

Tel: 021-021-33632979 15002134094
Fax: 021-33632979
Email: marketing@targetmol.com
Country: China
ProdList: 7854
Advantage: 58

Shanghai JONLN Reagent Co., Ltd.

Tel: 400-0066400 13621662912
Fax: 021-55660885
Email: 422131432@qq.com
Country: China
ProdList: 9986
Advantage: 55

ChemStrong Scientific Co.,Ltd

Tel: 0755-0755-66853366 13670046396
Fax: 0755-28363542
Email: sales@chem-strong.com
Country: China
ProdList: 17993
Advantage: 56

BrightGene Bio-medical Technology Co., Ltd.

Tel: 0512-0512-62551764 18013103761
Fax: 0512-62551799
Email: sales01@bright-gene.com
Country: China
ProdList: 61
Advantage: 70

Shanghai Yongye Biotechnology Co., Ltd.

Tel: 86-021-61559134 15921386130
Fax: 021-55068248
Email: 3423497944@qq.com
Country: China
ProdList: 8147
Advantage: 55

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66113011 18112977050
Email: cb6@aikonchem.com
Country: China
ProdList: 16687
Advantage: 50

Chizhou Kailong Import and Export Trade Co., Ltd.

Tel
Fax: -
Email: xg01_gj@163.com
Country: China
ProdList: 9503
Advantage: 50

Alta Scientific Co., Ltd.

Tel: 022-6537-8550 15522853686
Fax: 022-2532-9655
Email: sales@altasci.com.cn
Country: China
ProdList: 4515
Advantage: 55

Shanghai Synchem Pharma Co., ltd

Tel: 21-619849051-1 18521059765
Email: synchempharma@aliyun.com
Country: China
ProdList: 6456
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9708
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 27322
Advantage: 60

Raw material medicin reagent co.,Ltd

Tel
Email: sales@njromanme.com
Country: China
ProdList: 4534
Advantage: 58

Chengdu Dianchun Technology Co., Ltd

Tel: 400-1166-196 18502815961
Fax: QQ：800101999
Email: cdhxsj@163.com
Country: China
ProdList: 14623
Advantage: 60

ShangHai Biochempartner Co.,Ltd

Tel: 17754423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8012
Advantage: 62

Shanghai Chaolan Chemical Technology Center

Tel: QQ:65489617 15618227136
Fax: 21-5161 9052
Email: info@SuperLan-chem.com
Country: China
ProdList: 9854
Advantage: 58

Shanghai SuperLan Chemcial Technique Centre

Tel: 021-2022843681 15618226720
Fax: +86-21-51601218
Email: chaolaichem@foxmail.com
Country: China
ProdList: 9242
Advantage: 58

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 4009686088
Email: 3193328036@qq.com
Country: China
ProdList: 29795
Advantage: 68

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 18892239720
Fax: 010-60605840
Email: psaitong@jm-bio.com
Country: China
ProdList: 12308
Advantage: 58

Hubei widely chemical technology Co., Ltd.

Tel: 027-59402396 13419635609
Fax: 027-83989310
Email: 13419635609@163.com
Country: China
ProdList: 1991
Advantage: 55

Wuhan Wsem Biological Co., Ltd.

Tel: 027-83778876 13667159345
Fax: 027-83778876
Email: 13667159345@163.com
Country: China
ProdList: 1966
Advantage: 55

Guangzhou LES biological Technology Co.,Ltd.

Tel: 13672434928
Fax: -
Email: 3307355104@qq.com
Country: China
ProdList: 3650
Advantage: 58

Twochem Co.Ltd.

Tel: 021-58111628 15800915896
Fax: QQ 3285589261
Country: China
ProdList: 1988
Advantage: 58

Shanghai Zhibang Biological Medicine Co., LTD

Tel: 021-54285032 18116461626
Fax: 021-54285032
Email: 25493162@qq.com
Country: China
ProdList: 142
Advantage: 58

Zhengzhou Acme Chemical Co., Ltd.

Tel: 0371-0371-63315541 13323832564
Fax: QQ:3001332135
Email: 3001332135@qq.com
Country: China
ProdList: 9990
Advantage: 58

Shanghai Jizhi Biochemical Technology Co. Ltd.

Tel: 400-400-400-9004166 18616739031
Email: 3007523370@qq.com
Country: China
ProdList: 52712
Advantage: 58

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 13028896684
Email: sales@rrkchem.com
Country: China
ProdList: 56056
Advantage: 58

Fan De(Beijing) Biotechnology Co., Ltd.

Tel: 15911056312
Email: liming@bio-fount.com
Country: China
ProdList: 9730
Advantage: 58

Guangzhou Tomums Life Science Co., Ltd.

Tel: 020-31155029 18902330969
Fax: 020-31155029
Email: sales@tomums.cn
Country: China
ProdList: 4698
Advantage: 58

Zhejiang Zetian Fine Chemical Co., Ltd.

Tel: 0571-87682782 18957127338
Fax: QQ800182836
Email: sales@zetchem.com
Country: China
ProdList: 572
Advantage: 58

Tianjin Kaifu Pharmaceutical Technology Co., Ltd.

Tel: 18081075745
Email: chemflowtech@sina.com
Country: China
ProdList: 1886
Advantage: 58

Hebei Yanxi Chemical Co., Ltd.

Tel: +8617531190177
Email: peter@yan-xi.com
Country: China
ProdList: 6011
Advantage: 58

Wuhan wingroup Pharmaceutical Co., Ltd

Tel: +86-13296627870; +8613296627870
Fax: 0086-27-87819568
Email: info@whwingroup.com
Country: China
ProdList: 703
Advantage: 58

Guangzhou TongYi biochemistry technology Co.,LTD

Tel: +8613073028829
Email: mack@tongyon.com
Country: China
ProdList: 2996
Advantage: 58

Wuhan Golt Biotech Co., Ltd.

Tel: +8615389281203
Email: maria@goltbiotech.com
Country: China
ProdList: 980
Advantage: 58

XI'AN TIANGUANGYUAN BIOTECH CO., LTD.

Tel: +86-029-86333380 18829239519
Fax: 188 2923 9519
Email: sales06@tgybio.com
Country: China
ProdList: 931
Advantage: 58

AFINE CHEMICALS LIMITED

Tel: +86-0571-85134551
Fax: 008657185134895
Email: info@afinechem.com
Country: China
ProdList: 15396
Advantage: 58

Shaanxi Dideu Medichem Co. Ltd

Tel: +86-029-89586680 +86-18192503167
Fax: +86-29-88380327
Email: 1026@dideu.com
Country: China
ProdList: 9128
Advantage: 58

HANGZHOU CLAP TECHNOLOGY CO.,LTD

Tel: 86-571-88216897,88216896 13588875226
Fax: 86-571-88216895
Email: sales@hzclap.com
Country: CHINA
ProdList: 6313
Advantage: 58

HONG KONG IPURE BIOLOGY CO.,LIMITED

Tel: 86 18062405514 18062405514
Email: ada@ipurechemical.com
Country: CHINA
ProdList: 3465
Advantage: 58

Hubei Ipure Biology Co., Ltd

Tel: +8613367258412
Fax: 18062427325
Email: ada@ipurechemical.com
Country: China
ProdList: 10326
Advantage: 58

Henan Weituxi Chemical Technology Co., Ltd.

Tel: 0371-63284658 18135795563
Fax: QQ:2885349392
Email: 2885349392@qq.com
Country: China
ProdList: 10007
Advantage: 58

Less

View Lastest Price from Josamycin manufacturers

airuikechemical co., ltd.

Product: josamycin 16846-24-5
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99.99%
Supply Ability: 20 tons
Release date: 2024-04-10

Hebei Yanxi Chemical Co., Ltd.

Product: Josamycin 16846-24-5
Price: US $20.00-2.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 20 tons
Release date: 2023-09-15

Firsky International Trade (Wuhan) Co., Ltd

Product: Josamycin 16846-24-5
Price: US $30.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20T
Release date: 2023-09-26

16846-24-5, JosamycinRelated Search:

DL-CARNITINE Josamycin 2',9-dipropionate,Josamycin 9,2'-dipropionate,Josamycin dipropionate JOSAMYCIN EPY(CRM STANDARD) JOSAMYCIN PROPIONATE EPY(CRM STANDARD) JOSAMYCIN MM(CRM STANDARD) JOSAMYCIN PROPIONATE Deisovaleryl josamycin E,E-8,10-DODECADIEN-1-YL ACETATE 4-(Dimethylamino)tetrahydro-2H-pyran 2-Ethylhexyloxypropylamine Josamycin methyl 3-(acetoxy)octanoate 8,10-DODECADIEN-1-OL ISO-PROPYL-UNDECYLENATE ETHYL 3 ACETOXY HEXANOATE DL-3-ACETOXYBUTYRIC ACID ETHYL ESTER

Vilprafen

Wilprafen

Josamycin Solution, 100ppm

Josamycin for peak identification

3-Acetate 4B-(3-Methylbutanoate)leucoMycin V

LeucoMycin V, 3-acetate4B-(3-Methylbutanoate)

Leucomycin V 3-acetate 4''-(3-methylbutanoate)

YL-704A3

3-acetate4(supb)-(3-methylbutanoate)

C12662

Josamycin solution solution,1000ppm

Josamycin solution

JOSAMYCIN

LEUCOMYCIN V,3-AC-ETA 4B-(3-METHYLBUTANOATE)

LEUCOMYCIN V,3-ACETA 4BETA-(3-METHYL BUTANOATE)

LEUCOMYCIN A3

antibioticyl-704a3

kitasamycina3

leucomycinv,3-acetate4(supb)-(3-methylbutanoate)

turimycina5

EN 141

Iosalide

Jomybel

Josacine

Josamina

Leucomycin A3 (8CI)

Leucomycin V, 3-acetate 4B-(3-methylbutanoate) (9CI)

LEUCOMYCIN V,3-ACETA 4β-(3-METHYL BUTANOATE)

Josamycin Standard

Josamycin for peak identification CRS

Josamycin CRS

JOSAMYCIN USP/EP/BP

(2S,3S,4R,6S)-6-(((2R,3S,4R,5R,6S)-6-(((4R,5S,6S,7R,9R,10R,11E,13E,16R)-4-Acetoxy-10-hydroxy-5-methoxy-9,16-dimethyl-2-oxo-7-(2-oxoethyl)oxacyclohexadeca-11,13-dien-6-yl)oxy)-4-(dimethylamino)-5-hydroxy-2-methyltetrahydro-2H-pyran-3-yl)oxy)-4-hydroxy-2,4-

[(2S,3S,4R,6S)-6-[(2R,3S,4R,5R,6S)-6-[[(4R,5S,6S,7R,9R,10R,11E,13E,16R)-4-acetyloxy-10-hydroxy-5-methoxy-9,16-dimethyl-2-oxo-7-(2-oxoethyl)-1-oxacyclohexadeca-11,13-dien-6-yl]oxy]-4-(dimethylamino)-5-hydroxy-2-methyloxan-3-yl]oxy-4-hydroxy-2,4-dimethyloxa

Pre-validation

JOSAMYCIN(16846-24-5)

(4R,5S,6S,7R,9R,10R,11E,13E,16R)-4-(acetyloxy)-6-[[3,6-dideoxy-4-O-[2,6-dideoxy-3-C-methyl-4-O-(3-methylbutanoyl)-α-L-ribo-hexopyranosyl]-3-(dimethylamino)-β-D-glucopyranosyl]oxy]-10-hydroxy-5-methoxy-9,16-dimethyl-7-(2-oxoethyl)oxacyclohexadeca-11,13-dien-2-one (josamycin)

Sparsentan Impurity 65

Leucomycin A3 (>90%)

lucamycin

16846-24-5

C42H69NO15

BioChemical

Antibiotics

Antibiotics A to Z

Antibiotics G-M

Amines

Chiral Reagents

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals

Antibiotic Explorer

A - KAntibiotics

Antibacterial

Antibiotics A to

Antibiotics G-MAntibiotics

Chemical Structure Class

Interferes with Protein SynthesisAntibiotics