ChemicalBook > CAS DataBase List > 4-(tert-ButoxycarbonylaMino)-1-butanol

4-(tert-ButoxycarbonylaMino)-1-butanol

Product Name
4-(tert-ButoxycarbonylaMino)-1-butanol
CAS No.
75178-87-9
Chemical Name
4-(tert-ButoxycarbonylaMino)-1-butanol
Synonyms
tert-Butyl (4-hydroxybutyl)carbaMate;Boc-4-Abu-ol;4-Boc-Abu-ol;BOC-ABU(4)-OL;BOC-NH-(CH2)4-OH;BOC-4-AMINOBUTANOL;4-BOC AMINO BUTANOL;N-BOC-4-AMINOBUTANOL;4-(BOC-AMINO)-1-BUTANOL;N-Boc-4-Amino-1-butanol
CBNumber
CB5449521
Molecular Formula
C9H19NO3
Formula Weight
189.25
MOL File
75178-87-9.mol
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4-(tert-ButoxycarbonylaMino)-1-butanol Property

Melting point:
29 °C
Boiling point:
302.7±25.0 °C(Predicted)
Density 
1.02 g/mL at 20 °C(lit.)
refractive index 
n20/D 1.456
Flash point:
29 °C
storage temp. 
2-8°C
solubility 
Chloroform (Slightly), Methanol (Slightly)
pka
12.80±0.46(Predicted)
form 
Liquid or Low Melting Solid
color 
Colorless to yellow
BRN 
3603307
InChI
InChI=1S/C9H19NO3/c1-9(2,3)13-8(12)10-6-4-5-7-11/h11H,4-7H2,1-3H3,(H,10,12)
InChIKey
LIYMTLVBAVHPBU-UHFFFAOYSA-N
SMILES
C(OC(C)(C)C)(=O)NCCCCO
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Safety

WGK Germany 
3
F 
10-21
HazardClass 
IRRITANT
HS Code 
29221985
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
15302
Product name
4-(Boc-amino)-1-butanol
Purity
≥98.0% (GC)
Packaging
1ml
Price
$106
Updated
2025/07/31
Sigma-Aldrich
Product number
15302
Product name
4-(Boc-amino)-1-butanol
Purity
≥98.0% (GC)
Packaging
5ml
Price
$160.5
Updated
2025/07/31
TCI Chemical
Product number
B2868
Product name
4-(tert-Butoxycarbonylamino)-1-butanol
Purity
>96.0%(GC)
Packaging
5g
Price
$193
Updated
2025/07/31
TCI Chemical
Product number
B2868
Product name
4-(tert-Butoxycarbonylamino)-1-butanol
Purity
>96.0%(GC)
Packaging
25g
Price
$654
Updated
2025/07/31
TRC
Product number
B620825
Product name
4-(t-Boc-amino)-1-butanol
Packaging
1g
Price
$65
Updated
2021/12/16
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4-(tert-ButoxycarbonylaMino)-1-butanol Chemical Properties,Usage,Production

Chemical Properties

Light Yellow Liquid

Uses

Building block for spermidine analogues

Uses

4-(tert-ButoxycarbonylaMino)-1-butanol can be used as an intermediate for the synthesis of polymers used for in vivo delivery polyconjugate systems.

reaction suitability

reagent type: cross-linking reagent

Synthesis

13325-10-5

24424-99-5

75178-87-9

GENERAL STEPS: 4-Amino-1-butanol (0.5 g, 5.61 mmol) was dissolved in acetonitrile (56 mL). The reaction system was cooled to 0 °C, followed by the sequential addition of triethylamine (Et3N, 1.56 mL, 11.22 mmol, 2 equiv) and di-tert-butyl dicarbonate (Boc2O, 1.346 g, 6.17 mmol). The reaction progression was monitored by thin layer chromatography (TLC). After 6.5 h of reaction, the reaction was quenched by the addition of water (20 mL). The reaction mixture was extracted with ethyl acetate (EtOAc, 3 × 30 mL) and saturated saline was added to facilitate phase separation. The organic phases were combined, dried with anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure. The crude product was purified by silica gel fast column chromatography (eluent: dichloromethane/methanol, 95:5) to afford 4-(N-tert-butoxycarbonylamino)-1-butanol as a colorless oil (1.06 g, quantitative yield).

References

[1] Organic Letters, 2009, vol. 11, # 9, p. 2019 - 2022
[2] Bioorganic and Medicinal Chemistry, 2009, vol. 17, # 6, p. 2536 - 2543
[3] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 2, p. 1151 - 1155
[4] Bioorganic and Medicinal Chemistry, 2016, vol. 24, # 2, p. 191 - 200
[5] Inorganica Chimica Acta, 2016, vol. 452, p. 152 - 158

4-(tert-ButoxycarbonylaMino)-1-butanol Preparation Products And Raw materials

Raw materials

Preparation Products

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4-(tert-ButoxycarbonylaMino)-1-butanol Suppliers

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View Lastest Price from 4-(tert-ButoxycarbonylaMino)-1-butanol manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd
Product
Boc-4-Abu-ol 75178-87-9
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1T+
Release date
2024-01-18
Sichuan Jiaying Lai Technology Co.,LTD
Product
Boc-4-Abu-ol 75178-87-9
Price
US $1.00/g
Min. Order
1g
Purity
98%
Supply Ability
100KG
Release date
2019-07-18
Career Henan Chemical Co
Product
4-(tert-ButoxycarbonylaMino)-1-butanol 75178-87-9
Price
US $6.60/KG
Min. Order
1KG
Purity
97%-99%
Supply Ability
1kg -1000kg
Release date
2020-01-02

75178-87-9, 4-(tert-ButoxycarbonylaMino)-1-butanolRelated Search:

N-Boc-cadaverine Carbamic acid, (4-amino-2-butynyl)-, 1,1-dimethylethyl ester (9CI) Carbamic acid, (tetrahydro-4-oxo-2H-pyran-3-yl)-, 1,1-dimethylethyl ester (9CI) tert-butyl N-(4,4-dimethyl-3-oxopentyl)-N-methylcarbamate tert-butyl N-(4-hydroxy-3-methylcyclohexyl)carbamate tert-butyl N-(5-aminonaphthalen-1-yl)carbamate tert-butyl N-(5-{[(tert-butoxy)carbonyl]amino}-3-oxopentyl)c arbamate BOC-GAMMA-ABU-OH Boc-L-glutamic acid 1-tert-butyl ester Boc-L-Glutamic acid 1-benzyl ester N-tert-Butoxycarbonyl-L-glutamic acid gamma-tert-butyl ester Boc-D-Glu-OBzl Boc-L-Glutamic acid 1-Butanol BOC-GLU(OBZL)-OH DCHA BOC-GLU-LYS-LYS-MCA BOC-STA-OH BOC-GLU(OSU)-OBZL

  • BOC-NH-(CH2)4-OH
  • BOC-ABU(4)-OL
  • BOC-4-AMINOBUTANOL
  • 4-(TERT-BUTOXYCARBONYLAMINO)-1-BUTANOL
  • 4-(BOC-AMINO)-1-BUTANOL
  • N-(4-HYDROXYBUTYL)CARBAMIC ACID TERT-BUTYL ESTER
  • N-BOC-4-AMINOBUTANOL
  • N-T-BUTOXYCARBONYL-4-AMINO-1-BUTANOL
  • N-T-BUTOXYCARBONYL-DELTA-AMINO-N-BUTYL ALCOHOL
  • TERT-BUTYL N-(4-HYDROXYBUTYL)CARBAMATE
  • tert-butyl N-(4-hydroxybutyl)carbamate (en)
  • tert-Butyl (4-hydroxybutyl)carbaMate
  • 1,1-DiMethylethyl (4-Hydroxybutyl)carbaMate
  • N-(4-Hydroxybutyl)carbaMic Acid 1,1-DiMethylethyl Ester
  • N-Boc-4-aminobutanol tert-Butyl N-(4-Hydroxybutyl)carbamate N-(4-Hydroxybutyl)carbamic Acid tert-Butyl Ester
  • N-Boc-4-Amino-1-butanol
  • 4-(Boc-amino)-1-butanol >=98.0% (GC)
  • Boc-4-Abu-ol
  • 4-(Boc-amino)-1-butanol≥ 98% (HPLC)
  • 4-Boc-Abu-ol
  • Carbamic acid, (4-hydroxybutyl)-, 1,1-dimethylethyl ester
  • 4-(tert-Butoxycarbonylamino)-1-butanol &gt
  • 1,?4-?Butane-?1,?1,?2,?2,?3,?3,?4,?4-?d8-?diamine,?dihydrochloride?(9CI)
  • Carbamic acid, N-(4-hydroxybutyl)-, 1,1-dimethylethyl ester
  • 4-(tert-ButoxycarbonylaMino)-1-butanol USP/EP/BP
  • (4-hydroxybutyl)carbamic acid tert-butyl ester
  • 4-BOC AMINO BUTANOL
  • 75178-87-9
  • 75179-87-9
  • CH33CO2CNHCH24OH
  • Amino Alcohols
  • Building Blocks
  • Organic Building Blocks
  • Oxygen Compounds
  • Aliphatics
  • Amino Acids & Derivatives