N-[3-(1,3-benzodioxol-5-yl)-3-(2-methoxyphenyl)propyl]-N-benzylpropanamide

Product Name: N-[3-(1,3-benzodioxol-5-yl)-3-(2-methoxyphenyl)propyl]-N-benzylpropanamide
CAS No.: 330834-54-3
Chemical Name: N-[3-(1,3-benzodioxol-5-yl)-3-(2-methoxyphenyl)propyl]-N-benzylpropanamide
Synonyms: AGX51 ，E1152;AGX51, 10 mM in DMSO;ubiquitin,AGX 51,Inhibitor,AGX51,anti-tumor,TNBC,AGX-51,inhibit;N-[3-(1,3-benzodioxol-5-yl)-3-(2-methoxyphenyl)propyl]-N-benzylpropanamide;N-(3-(Benzo[d][1,3]dioxol-5-yl)-3-(2-methoxyphenyl)propyl)-N-benzylpropionamide;N-Benzyl-N-(3-(2,3-dihydrobenzofuran-6-yl)-3-(2-methoxyphenyl)propyl)propionamide;Propanamide, N-[3-(1,3-benzodioxol-5-yl)-3-(2-methoxyphenyl)propyl]-N-(phenylmethyl)-
CBNumber: CB54504336
Molecular Formula: C27H29NO4
Formula Weight: 431.52
MOL File: 330834-54-3.mol

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N-[3-(1,3-benzodioxol-5-yl)-3-(2-methoxyphenyl)propyl]-N-benzylpropanamide Property

Boiling point:: 609.4±55.0 °C(Predicted)
Density: 1.169±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: 250 mg/mL (579.35 mM); Ethanol: 100 mg/mL (231.74 mM); Water: < 0.1 mg/mL (insoluble)
form: Oil
pka: -0.50±0.70(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML3635
Product name: AGX51
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $371.45
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML3635
Product name: AGX51
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $1453.5
Updated: 2025/07/31

American Custom Chemicals Corporation

Product number: CHM0234582
Product name: N-[3-(1,3-BENZODIOXOL-5-YL)-3-(2-METHOXYPHENYL)PROPYL]-N-BENZYLPROPANAMIDE
Purity: 95.00%
Packaging: 5MG
Price: $495.58
Updated: 2021/12/16

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N-[3-(1,3-benzodioxol-5-yl)-3-(2-methoxyphenyl)propyl]-N-benzylpropanamide Chemical Properties,Usage,Production

Uses

AGX51 is the first-in-class pan-Id (inhibitors of DNA-binding/differentiation proteins) antagonist and degrader. AGX51 inhibits Id1-E47 interaction, leading to ubiquitin-mediated degradation of Ids, cell growth arrest, and viability reduction. AGX51 can inhibit TNBC and has an IC50 of about 25 nM. AGX51 can be used in cancer research.

Biological Activity

AGX51 is an antagonist th at blocks transcriptional regulators ID1-4 from binding basic helix-loop-helix (bHLH) transcription factor E47, causing ubiquitin-mediated degradation of IDs (10-40 μM for 2-48h; HCT116). AGX51 reduces cell viability, G0/G1 growth arrest, and a reduction in cyclin D1 levels in cultures (5-40 μM for 4-24h; HUVEC and HCT116) and suppresses ocular neovascularization in mouse models of age-related macular degeneration (AMD) and retinopathy of prematurity (ROP) in vivo (500 μg/mouse via twice daily i.p. or 1-30 μg/eye via intravitreal injection immediately and 7 days after rupture of Bruch's membrane).

in vivo

AGX51 (50 mg/kg; i.p. twice a day for 4 weeks) inhibits lung metastasis^[1]. AGX51 (15 mg/kg; i.p. twice a day for 3 weeks) exibits anti-tumor activity with autochronous cancer^[1].

Animal Model:	Balb/c mice with luciferase-labeled 4T1 cells^[1]
Dosage:	50 mg/kg
Administration:	Intraperitoneal injection; 60 mg/kg twice a day; for 4 weeks
Result:	Inhibited lung metastasis development.

Animal Model:	A/J mice with AOM colon tumor model^[1]
Dosage:	15 mg/kg
Administration:	Intraperitoneal injection; 15 mg/kg twice a day; for 3 weeks
Result:	Dreased the colon tumors and exhibited anti-tumor activity in AOM colon tumor mice.

References

[1] Wojnarowicz PM, et al. Anti-tumor effects of an ID antagonist with no observed acquired resistance. NPJ Breast Cancer. 2021 May 24;7(1):58. DOI:10.1038/s41523-021-00266-0

N-[3-(1,3-benzodioxol-5-yl)-3-(2-methoxyphenyl)propyl]-N-benzylpropanamide Preparation Products And Raw materials

Raw materials

Preparation Products

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N-[3-(1,3-benzodioxol-5-yl)-3-(2-methoxyphenyl)propyl]-N-benzylpropanamide Suppliers

China 26 Finland 2 United States 5 Global 33

Bide Pharmatech Ltd.

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TargetMol Chemicals Inc.

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ChemeGen(Shanghai) Biotechnology Co.,Ltd.

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Beijing Jin Ming Biotechnology Co., Ltd.

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JinOu Biomedical (Nanjing) Co., Ltd.

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TargetMol Chemicals Inc.

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330834-54-3, N-[3-(1,3-benzodioxol-5-yl)-3-(2-methoxyphenyl)propyl]-N-benzylpropanamideRelated Search:

N-[3-(1,3-benzodioxol-5-yl)-3-(2-methoxyphenyl)propyl]-N-benzylpropanamide

ubiquitin,AGX 51,Inhibitor,AGX51,anti-tumor,TNBC,AGX-51,inhibit

Propanamide, N-[3-(1,3-benzodioxol-5-yl)-3-(2-methoxyphenyl)propyl]-N-(phenylmethyl)-

AGX51, 10 mM in DMSO

N-Benzyl-N-(3-(2,3-dihydrobenzofuran-6-yl)-3-(2-methoxyphenyl)propyl)propionamide

N-(3-(Benzo[d][1,3]dioxol-5-yl)-3-(2-methoxyphenyl)propyl)-N-benzylpropionamide

AGX51 ，E1152

330834-54-3