ACETONYLMALONIC ACID DIETHYL ESTER
- Product Name
- ACETONYLMALONIC ACID DIETHYL ESTER
- CAS No.
- 23193-18-2
- Chemical Name
- ACETONYLMALONIC ACID DIETHYL ESTER
- Synonyms
- DIETHYL ACETONYLMALONATE;DIETHYL 2-OXOPROPYLMALONATE;Diethyl Acetonylmalonate >Diethyl 2-(2-oxopropyl)Malonate;ethyl 2-carbethoxy-4-oxo-valerate;ACETONYLMALONIC ACID DIETHYL ESTER;diethyl 2-(2-oxopropyl)propanedioate;2-OXOPROPYLMALONIC ACID DIETHYL ESTER;1,3-diethyl 2-(2-oxopropyl)propanedioate;2-Oxopropylmalonic acid eiethyl ester
- CBNumber
- CB5459968
- Molecular Formula
- C10H16O5
- Formula Weight
- 216.23
- MOL File
- 23193-18-2.mol
ACETONYLMALONIC ACID DIETHYL ESTER Property
- Boiling point:
- 296.4±20.0℃ (760 Torr)
- Density
- 1.091±0.06 g/cm3 (20 ºC 760 Torr)
- refractive index
- 1.4388 (20℃)
- Flash point:
- 126.9±21.8℃
- storage temp.
- 2-8°C
- form
- clear liquid
- pka
- 11.80±0.59(Predicted)
- color
- Colorless to Light yellow
Safety
- HS Code
- 2918.30.9000
N-Bromosuccinimide Price
- Product number
- A1503
- Product name
- Diethyl Acetonylmalonate
- Purity
- >95.0%(GC)
- Packaging
- 1g
- Price
- $37
- Updated
- 2025/07/31
- Product number
- A1503
- Product name
- Diethyl Acetonylmalonate
- Purity
- >95.0%(GC)
- Packaging
- 5g
- Price
- $111
- Updated
- 2025/07/31
- Product number
- B400015
- Product name
- AcetonylmalonicAcidDiethylEster
- Packaging
- 500mg
- Price
- $155
- Updated
- 2021/12/16
- Product number
- 7004AL
- Product name
- Acetonylmalonicaciddiethylester
- Packaging
- 5g
- Price
- $423
- Updated
- 2021/12/16
- Product number
- CHM0013504
- Product name
- ACETONYLMALONIC ACID DIETHYL ESTER
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $683.99
- Updated
- 2021/12/16
ACETONYLMALONIC ACID DIETHYL ESTER Chemical Properties,Usage,Production
Uses
Diethyl Acetonylmalonate is a doubly functionalized reagent, the ketone acting as an internal trapping agent after the reaction of the malonate anion; for synthesis of five-membered rings.
Synthesis Reference(s)
The Journal of Organic Chemistry, 46, p. 4631, 1981 DOI: 10.1021/jo00335a084
Synthesis
A detailed procedure reports the alkylation of Diethyl Malonate by chloroacetone on a 100 g scale, giving diethyl acetonylmalonate (1) with a yield of 55% after distillation. Since chloroacetone is toxic and highly irritating to the eyes, skin, and mucous membranes, an alternative procedure using Isopropenyl Acetate, a mild irritant and a much less toxic compound than chloroacetone, should be seriously considered. Thus the reaction of dimethyl malonate with isopropenyl acetate in the presence of Cerium(IV) Ammonium Nitrate (CAN) followed by a mild basic treatment affords dimethyl acetonylmalonate in a yield of 82% on a 5-10 g scale (eq 1). This procedure offers advantages regarding the yield and reaction conditions, and it uses available starting materials.
References
1. Mercier C.; Addas A. R.; Deslongchamps P. CJC 1972, 50, 1882.
2. The Merck Index, 11th ed.; Merck: Rahway, NJ, 1989.
3. Baciocchi E.; Civitarese G.; Ruzziconi R. TL 1987, 28, 5357.
ACETONYLMALONIC ACID DIETHYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
ACETONYLMALONIC ACID DIETHYL ESTER Suppliers
- Tel
- 03-36680489
- Fax
- 03-3668-0520
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- Country
- Japan
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