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None

Product Name: None
CAS No.: 2163056-91-3
Chemical Name: None
Synonyms: B1-1347;BI-1347 (BI1347);BI-1347, 10 mM in DMSO;1H-Pyrazole-1-acetamide, 4-[4-(4-isoquinolinyl)phenyl]-N,N-dimethyl-;2-(4-(4-(Isoquinolin-4-yl)phenyl)-1H-pyrazol-1-yl)-N,N-dimethylacetamide;BI-1347,None,2-{4-[4-(isoquinolin-4-yl)phenyl]-1H-pyrazol-1-yl}-N,N-dimethylacetamide;BI1347,oral activity,human NK92MI cell,BI-1347,Inhibitor,CDK,mouse splenic NK cell,BI 1347,anti-tumoral activity,inhibit,Cyclin dependent kinase,selectivity
CBNumber: CB54656561
Molecular Formula: C22H20N4O
Formula Weight: 356.42
MOL File: 2163056-91-3.mol

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None Property

storage temp.: Store at -20°C
solubility: DMSO:98.0(Max Conc. mg/mL);274.95(Max Conc. mM)
Ethanol:3.0(Max Conc. mg/mL);8.42(Max Conc. mM)
form: Solid
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0077644
Product name: BI-1347
Purity: 99.83%
Packaging: 5mg
Price: $100
Updated: 2021/12/16

ChemScene

Product number: CS-0077644
Product name: BI-1347
Purity: 99.83%
Packaging: 10mg
Price: $160
Updated: 2021/12/16

ChemScene

Product number: CS-0077644
Product name: BI-1347
Purity: 99.83%
Packaging: 100mg
Price: $950
Updated: 2021/12/16

DC Chemicals

Product number: DC20775
Product name: BI-1347
Purity: >98%
Packaging: 100mg
Price: $550
Updated: 2021/12/16

DC Chemicals

Product number: DC20775
Product name: BI-1347
Purity: >98%
Packaging: 1g
Price: $1800
Updated: 2021/12/16

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None Chemical Properties,Usage,Production

Uses

BI-1347 is an orally active, selective and potent CDK8 inhibitor (IC50=1.1 nM). BI-1347 shows anti-tumoral activity[1][2].

in vivo

BI-1347 (oral gavage; 10 mg/kg; once daily; 30 d) modulates STAT1^S727 phosphorylation and shows anti-tumor activity in vivo^[2].
BI-1347 (oral gavage; 10 mg/kg) intermittent schedule and BI-8382 continuous treatment combination treatment increases efficacy compared to each monotherapy in the mammary carcinoma EMT6 model^[2].

Animal Model:	B16-F10-luc2 syngeneic melanoma model^[2]
Dosage:	10 mg/kg
Administration:	Oral gavage; 10 mg/kg; once daily; 30 d
Result:	Reduced phosphorylation of STAT1^S727 for at least 6 h by 60%. Showed minimal effect on body weight at 10 mg/kg. Showed lower tumor burden both on day 23 and 29, compared to the control group.

IC 50

CDK8: 1.1 nM (IC₅₀)

References

[1] Harald Engelhardt, et al. New phenylpyrazolylacetamide compounds and derivatives as cdk8/cdk19 inhibitors.
[2] Hofmann MH, et al. Selective and Potent CDK8/19 Inhibitors Enhance NK-Cell Activity and Promote Tumor Surveillance. Mol Cancer Ther. 2020 Apr;19(4):1018-1030. DOI:10.1158/1535-7163.MCT-19-0789

None Preparation Products And Raw materials

Raw materials

Preparation Products

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2163056-91-3, NoneRelated Search:

BI-1347 (BI1347)

1H-Pyrazole-1-acetamide, 4-[4-(4-isoquinolinyl)phenyl]-N,N-dimethyl-

2-(4-(4-(Isoquinolin-4-yl)phenyl)-1H-pyrazol-1-yl)-N,N-dimethylacetamide

BI-1347,None,2-{4-[4-(isoquinolin-4-yl)phenyl]-1H-pyrazol-1-yl}-N,N-dimethylacetamide

BI1347,oral activity,human NK92MI cell,BI-1347,Inhibitor,CDK,mouse splenic NK cell,BI 1347,anti-tumoral activity,inhibit,Cyclin dependent kinase,selectivity

BI-1347, 10 mM in DMSO

B1-1347

2163056-91-3