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WOBE437

Product Name
WOBE437
CAS No.
2108100-73-6
Chemical Name
WOBE437
Synonyms
WOBE437;(2E,4E)-N-[2-(3,4-Dimethoxyphenyl)ethyl]dodeca-2,4-dienamide;(2E,4E)-N-[2-(3,4-dimethoxyphenyl)ethyl]-2,4-dodecadienamide;2,4-Dodecadienamide, N-[2-(3,4-dimethoxyphenyl)ethyl]-, (2E,4E)-
CBNumber
CB54666832
Molecular Formula
C22H33NO3
Formula Weight
359.5
MOL File
2108100-73-6.mol
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WOBE437 Property

storage temp. 
Store at -20°C
solubility 
DMF: 2.5 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 1 mg/ml
form 
A crystalline solid
color 
white to beige
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
23506
Product name
WOBE437
Purity
≥97%
Packaging
1mg
Price
$81
Updated
2024/03/01
Cayman Chemical
Product number
23506
Product name
WOBE437
Purity
≥97%
Packaging
5mg
Price
$356
Updated
2024/03/01
Cayman Chemical
Product number
23506
Product name
WOBE437
Purity
≥97%
Packaging
10mg
Price
$632
Updated
2024/03/01
AK Scientific
Product number
1479EN
Product name
(2E,4E)-N-[2-(3,4-Dimethoxyphenyl)ethyl]dodeca-2,4-dienamide
Packaging
1mg
Price
$187
Updated
2021/12/16
AK Scientific
Product number
1479EN
Product name
(2E,4E)-N-[2-(3,4-Dimethoxyphenyl)ethyl]dodeca-2,4-dienamide
Packaging
5mg
Price
$495
Updated
2021/12/16
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WOBE437 Chemical Properties,Usage,Production

Description

WOBE437 is a potent endocannabinoid uptake inhibitor with IC50 values of 10 and 283 nM for arachidonoyl ethanolamide (AEA; ) and 2-arachidonoyl glycerol (2-AG; ) uptake, respectively, in U937 cells. It is greater than 1,000-fold selective for endocannabinoid transporters over fatty acid amide hydrolase (FAAH; ) and the 2-AG hydrolyzing enzymes MAGL, ABHD6, and ABHD12. WOBE437 inhibits AEA uptake in FAAH-deficient HMC-1 human mast cells and Neuro2a mouse neuroblastoma cells (IC50s = 137 and 55 nM, respectively) and reduces AEA uptake by 50% in rat cortical neurons when used at a concentration of 1 μM. It also reduces 2-AG uptake by 40% in Neuro2a cells at a concentration of 5 μM. In vivo, WOBE437 increases AEA and 2-AG levels by 1.5-fold in mouse brain but not peripheral tissues after intraperitoneal administration of a 10 mg/kg dose for seven days. WOBE437 (10 mg/kg) also induces a typical tetrad of hypothermia, catalepsy, analgesia, and hypomotility in mice, indicating it also acts as an indirect cannabinoid (CB) receptor 1 agonist.

Uses

WOBE437 is a biochemical reagent.

References

[1] ANDREA CHICCA. Chemical probes to potently and selectively inhibit endocannabinoid cellular reuptake.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2017, 114 25: E5006-E5015. DOI: 10.1073/pnas.1704065114

WOBE437 Preparation Products And Raw materials

Raw materials

Preparation Products

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WOBE437 Suppliers

China 6 United States 2 Global 8
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
ProdList
9923
Advantage
65
Shanghai Hongye Biotechnology Co. Ltd
Tel
400-9205774
Email
sales@glpbio.cn
Country
China
ProdList
6777
Advantage
58
TargetMol Chemicals Inc.
Tel
15002134094
Email
marketing@targetmol.cn
Country
China
ProdList
29358
Advantage
58
Cayman Chemical Company
Tel
800-364-9897
Email
sales@caymanchem.com
Country
China
ProdList
6838
Advantage
58
Merck KGaA
Tel
21-20338288
Email
ordercn@merckgroup.com
Country
China
ProdList
6394
Advantage
58
Biosynth Biological Technology (Suzhou) Co Ltd
Tel
51288865780
Email
sales@biosynth.com
Country
China
ProdList
6051
Advantage
58
Guangzhou Qiansheng Biotechnology Co., Ltd.
Tel
14748676110
Country
CHINA
ProdList
112
Advantage
58

2108100-73-6, WOBE437Related Search:


  • WOBE437
  • 2,4-Dodecadienamide, N-[2-(3,4-dimethoxyphenyl)ethyl]-, (2E,4E)-
  • (2E,4E)-N-[2-(3,4-dimethoxyphenyl)ethyl]-2,4-dodecadienamide
  • (2E,4E)-N-[2-(3,4-Dimethoxyphenyl)ethyl]dodeca-2,4-dienamide
  • 2108100-73-6