MitoPerOx

Product Name: MitoPerOx
CAS No.: 1392820-50-6
Chemical Name: MitoPerOx
Synonyms: MitoPerOx;MitoPerOx (cis- and trans- mixture);MitoPerOx, fluorescent mitochondria-targeted lipid peroxidation probe;(2-(3-(5,5-difluoro-7-((1E,3E)-4-phenylbuta-1,3-dien-1-yl)-5H-5λ4,6λ4-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinin-3-yl)propanamido)ethyl)triphenylphosphonium,monobromide
CBNumber: CB54667026
Molecular Formula: C42H38BBrF2N3OP*
Formula Weight: 760.4561874
MOL File: 1392820-50-6.mol

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MitoPerOx Property

storage temp.: Store at -20°C
solubility: DMSO: 25 mM
form: A solid
color: Dark purple to black
InChIKey: UDTNTHFRCJAKLR-GPSHETCQSA-N
SMILES: O=C(CCC1N2B([N]3C(=CC2=CC=1)C=CC=3/C=C/C=C/C1C=CC=CC=1)(F)F)NCC[P+](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1.[Br-] |^1:7|

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 18798
Product name: MitoPerOx
Purity: ≥95%
Packaging: 1mg
Price: $578
Updated: 2024/03/01

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MitoPerOx Chemical Properties,Usage,Production

Description

MitoPerOx is a ratiometric fluorescent probe that can be used to assess changes in lipid peroxidation within mitochondria. It is composed of a BODIPY fluorophore conjugated via a dienyl link to a triphenylphosphonium cation component that drives its accumulation in mitochondria. MitoPerOx displays an excitation maximum of 495 nm and exhibits a shift in emission maxima from 590 to 520 nm upon mitochondrial lipid peroxidation, enabling determination of ratiometric measurements of lipid peroxidation in live cells.

Uses

MitoPerOx is a mitochondrial-targeted, lipid peroxidation-indicating fluorescent probe with BODIPY581/591 fluorophores. The triphenylphosphine cation (TPP+) of MitoPerOx can be selectively enriched in mitochondria (depending on membrane potential) and can be used to detect lipid peroxidation in the inner mitochondrial membrane. Under the action of lipid peroxides, the BODIPY581/591 fluorophores of MitoPerOx shift their emission wavelength from 590 nm (reduced state) to 520 nm (oxidized state), and ratiometric detection can be performed at an excitation wavelength of 488 nm. MitoPerOx can specifically monitor the peroxidation of mitochondrial phospholipids (especially cardiolipin) and is used in the study of oxidative stress-related diseases (such as aging, neurodegenerative diseases, and mitochondrial dysfunction)[1][2].

References

[1] Lyamzaev KG, Sumbatyan NV, Nesterenko AM, Kholina EG, Voskoboynikova N, Steinhoff HJ, Mulkidjanian AY, Chernyak BV. MitoCLox: A Novel Mitochondria-Targeted Fluorescent Probe for Tracing Lipid Peroxidation. Oxid Med Cell Longev. 2019 Nov 13;2019:9710208. DOI:10.1155/2019/9710208
[2] Prime TA, et, al. A ratiometric fluorescent probe for assessing mitochondrial phospholipid peroxidation within living cells. Free Radic Biol Med. 2012 Aug 1;53(3):544-53. DOI:10.1016/j.freeradbiomed.2012.05.033

MitoPerOx Preparation Products And Raw materials

Raw materials

Preparation Products

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MitoPerOx Suppliers

China 17 United States 4 Global 21

Shanghai Annengjian Biomedical Technology Co., LTD

Tel: 021-68781987 13818305065
Email: sales@energybiopharma.com
Country: China
ProdList: 652
Advantage: 58

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Xi'an Confluore Biological Technology Co., Ltd.

Tel: +86-156-80926068 +86-15680926068
Email: 1924344760@qq.com
Country: China
ProdList: 4952
Advantage: 58

Henan's chemical products co., LTD

Tel: 0371-60919097 15378766539
Fax: 0371-60919097
Email: 794449696@qq.com
Country: China
ProdList: 4996
Advantage: 58

Shanghai Hongye Biotechnology Co. Ltd

Tel: 400-9205774
Email: sales@glpbio.cn
Country: China
ProdList: 6777
Advantage: 58

Henan Alpha Chemical Co., Ltd.

Tel: 0371-55055611 18137792234
Fax: QQ：3002694073
Email: 3002694073@qq.com
Country: China
ProdList: 9987
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11218
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Shanghai Universal Biotech Co.,Ltd

Tel: 15921930842 15921930842
Email: yh-wang@univ-bio.com
Country: China
ProdList: 25004
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24961
Advantage: 58

Shanghai Yiyan Biotechnology Co. , Ltd.

Tel: 021-69985186 13611928337
Email: 3427709316@qq.com
Country: China
ProdList: 7982
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Shanghai Aladdin Biochemical Technology Co.,Ltd.

Tel: 400-6206333 13167063860
Email: anhua.mao@aladdin-e.com
Country: China
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Shaanxi Istare Biotechnology Co., Ltd.

Tel: 18682931470; 18682931470
Email: 2142355700@qq.com
Country: China
ProdList: 4723
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Cayman Chemical Company

Tel: 800-364-9897
Email: sales@caymanchem.com
Country: China
ProdList: 6838
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Zhengzhou Haochuang New Material Co., Ltd.

Tel: 19139721821
Email: 3545426645@qq.com
Country: China
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Xian confluore Biological Technology Co., Ltd.

Tel: +86-15680926068
Email: 1924344760@confluore.cn
Country: China
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Advantage: 58

Sperui Technology (Guangzhou) Co., Ltd.

Tel: 18826050589
Country: CHINA
ProdList: 186
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View Lastest Price from MitoPerOx manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: MitoPerOx 1392820-50-6
Price: US $0.00/mg
Min. Order: 10mg
Purity: >98.00%
Supply Ability: 10mg
Release date: 2024-03-28

1392820-50-6, MitoPerOxRelated Search:

MitoPerOx

(2-(3-(5,5-difluoro-7-((1E,3E)-4-phenylbuta-1,3-dien-1-yl)-5H-5λ4,6λ4-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinin-3-yl)propanamido)ethyl)triphenylphosphonium,monobromide

MitoPerOx (cis- and trans- mixture)

MitoPerOx, fluorescent mitochondria-targeted lipid peroxidation probe

1392820-50-6