KU-32

Product Name: KU-32
CAS No.: 956498-70-7
Chemical Name: KU-32
Synonyms: KU-32;KU 32,KU32;Acetamide, N-[7-[(6-deoxy-5-C-methyl-4-O-methyl-α-L-lyxo-hexopyranosyl)oxy]-8-methyl-2-oxo-2H-1-benzopyran-3-yl]-
CBNumber: CB54668119
Molecular Formula: C20H25NO8
Formula Weight: 407.42
MOL File: 956498-70-7.mol

More

Less

KU-32 Property

Boiling point:: 668.1±55.0 °C(Predicted)
Density: 1.37±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
pka: 12.20±0.20(Predicted)

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

KU-32 Chemical Properties,Usage,Production

Description

KU-32 is a C-terminal inhibitor of Hsp90 which increases Hsp70 expression, and protects against neuronal glucotoxicity and reverses multiple clinical indices of diabetic peripheral neuropathy.

Uses

KU-32 is a novel, novobiocin-based Hsp90 inhibitor that can protect against neuronal cell death.

in vivo

Diabetic BKS-db/db mice, a model for type 2 diabetes, administered KU-32 for 10 weeks do not show any significant changes in blood glucose and insulin levels, despite having greater insulin staining/beta cell in the pancreas compared to untreated BKS db/db mice^[1].

References

[1] Farmer K, et al. KU-32, a novel drug for diabetic neuropathy, is safe for human islets and improves in vitro insulin secretion and viability. Exp Diabetes Res. 2012;2012:671673. DOI:10.1155/2012/671673
[2] Urban MJ, et al. Inhibiting heat-shock protein 90 reverses sensory hypoalgesia in diabetic mice. ASN Neuro. 2010 Aug 11;2(4):e00040. DOI:10.1042/AN20100015

KU-32 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

KU-32 Suppliers

China 7 United States 1 Global 8

Fan De(Beijing) Biotechnology Co., Ltd.

Tel: 15911056312
Email: liming@bio-fount.com
Country: China
ProdList: 9729
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
Advantage: 58

cjbscvictory

Tel: 13348960310
Email: 3003867561@qq.com
Country: China
ProdList: 10503
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24961
Advantage: 58

Shanghai Yiyan Biotechnology Co. , Ltd.

Tel: 021-69985186 13611928337
Email: 3427709316@qq.com
Country: China
ProdList: 7982
Advantage: 58

Nanjing Shizhou Biology Technology Co.,Ltd

Tel: 025-85560043 15850508050
Fax: 025-85563444
Email: cindy.huang@synzest.com
Country: China
ProdList: 12000
Advantage: 58

Biosynth Biological Technology (Suzhou) Co Ltd

Tel: 51288865780
Email: sales@biosynth.com
Country: China
ProdList: 6051
Advantage: 58

Adooq Bioscience LLC

Tel: 400-025-6535
Email: sales@adooq.cn
Country: China
ProdList: 6215
Advantage: 58

956498-70-7, KU-32Related Search:

KU-32

KU 32,KU32

Acetamide, N-[7-[(6-deoxy-5-C-methyl-4-O-methyl-α-L-lyxo-hexopyranosyl)oxy]-8-methyl-2-oxo-2H-1-benzopyran-3-yl]-

956498-70-7