M-443

Product Name: M-443
CAS No.: 1820684-31-8
Chemical Name: M-443
Synonyms: M-443;M-443 (M443;M443, 10 mM in DMSO;Benzamide, 4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[[4-[1-(1-oxo-2-propen-1-yl)-3-piperidinyl]-2-pyrimidinyl]amino]-
CBNumber: CB54668159
Molecular Formula: C31H30F3N7O2
Formula Weight: 589.61
MOL File: 1820684-31-8.mol

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M-443 Property

Density: 1.34±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 55 mg/mL (93.28 mM)
form: Solid
pka: 12.95±0.70(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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M-443 Chemical Properties,Usage,Production

Description

M443 is a specific small molecule inhibitor of MRK. M443 strongly radiosensitizes UW228 medulloblastoma cells as well as UI226 patient-derived primary cells, whereas it does not affect the response to radiation of normal brain cells. M443 also inhibits radiation-induced activation of both p38 and Chk2, two proteins that act downstream of MRK and are involved in DNA damage-induced cell-cycle arrest.

M-443 Preparation Products And Raw materials

Raw materials

Preparation Products

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M-443 Suppliers

China 9 United States 1 Global 10

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1820684-31-8, M-443Related Search:

M-443

M-443 (M443

Benzamide, 4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[[4-[1-(1-oxo-2-propen-1-yl)-3-piperidinyl]-2-pyrimidinyl]amino]-

M443, 10 mM in DMSO

1820684-31-8

C31H30F3N7O2