ChemicalBook > CAS DataBase List > M-443
M-443
- Product Name
- M-443
- CAS No.
- 1820684-31-8
- Chemical Name
- M-443
- Synonyms
- M-443;M-443 (M443;M443, 10 mM in DMSO;Benzamide, 4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[[4-[1-(1-oxo-2-propen-1-yl)-3-piperidinyl]-2-pyrimidinyl]amino]-
- CBNumber
- CB54668159
- Molecular Formula
- C31H30F3N7O2
- Formula Weight
- 589.61
- MOL File
- 1820684-31-8.mol
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M-443 Property
- Density
- 1.34±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : 55 mg/mL (93.28 mM)
- form
- Solid
- pka
- 12.95±0.70(Predicted)
- color
- Light yellow to yellow
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M-443 Chemical Properties,Usage,Production
Description
M443 is a specific small molecule inhibitor of MRK. M443 strongly radiosensitizes UW228 medulloblastoma cells as well as UI226 patient-derived primary cells, whereas it does not affect the response to radiation of normal brain cells. M443 also inhibits radiation-induced activation of both p38 and Chk2, two proteins that act downstream of MRK and are involved in DNA damage-induced cell-cycle arrest.
M-443 Preparation Products And Raw materials
Raw materials
Preparation Products
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M-443 Suppliers
- Tel
- +1-781-999-5354 +1-00000000000
- marketing@targetmol.com
- Country
- United States
- ProdList
- 32161
- Advantage
- 58