MGV354

Product Name: MGV354
CAS No.: 1852495-86-3
Chemical Name: MGV354
Synonyms: MGV354;(Rac)-MGV354;MGV354|MGV 354;pressure,drop,intraocular,Guanylate Cyclase,(Rac)MGV354,Inhibitor,activator,topical,(Rac) MGV354,inhibit,sGC,(Rac)-MGV354,(Rac)-MGV-354,ocular;1-[6-(3-{[4-(1-cyclopropanecarbonylpiperidin-4-yl)-2-methylphenyl]amino}-2,3-dihydro-1H-inden-4-yl)pyridin-2-yl]-5-methyl-1H-pyrazole-4-carboxylic acid
CBNumber: CB54668179
Molecular Formula: C35H37N5O3
Formula Weight: 575.71
MOL File: 1852495-86-3.mol

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MGV354 Property

Boiling point:: 824.8±65.0 °C(Predicted)
Density: 1.36±0.1 g/cm3(Predicted)
solubility: DMSO : 100 mg/mL (173.70 mM; Need ultrasonic)
pka: 3.20±0.25(Predicted)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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MGV354 Chemical Properties,Usage,Production

Biological Activity

(Rac)-MGV354 is the racemate of MGV354. MGV354 is a soluble guanylate cyclase (sGC) activator with EC50s of <0.5 nM, and 5 nM in CHO and GTM-3 E cells, respectively[1].

References

[1]. Ehara T, et al. The Discovery of ( S)-1-(6-(3-((4-(1-(Cyclopropanecarbonyl)piperidin-4-yl)-2-methylphenyl)amino)-2,3-dihydro-1 H-inden-4-yl)pyridin-2-yl)-5-methyl-1 H-pyrazole-4-carboxylic Acid, a Soluble Guanylate Cyclase Activator Specifically Designed for Topical Ocular Delivery as a Therapy for Glaucoma. J Med Chem. 2018 Mar 22;61(6):2552-2570.

MGV354 Preparation Products And Raw materials

Raw materials

Preparation Products

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1852495-86-3, MGV354Related Search:

MGV354

(Rac)-MGV354

pressure,drop,intraocular,Guanylate Cyclase,(Rac)MGV354,Inhibitor,activator,topical,(Rac) MGV354,inhibit,sGC,(Rac)-MGV354,(Rac)-MGV-354,ocular

MGV354|MGV 354

1-[6-(3-{[4-(1-cyclopropanecarbonylpiperidin-4-yl)-2-methylphenyl]amino}-2,3-dihydro-1H-inden-4-yl)pyridin-2-yl]-5-methyl-1H-pyrazole-4-carboxylic acid

1852495-86-3