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Parsaclisib

Product Name
Parsaclisib
CAS No.
1426698-88-5
Chemical Name
Parsaclisib
Synonyms
Parsaclisib;Parsaclisib(INCB050465);Parsaclisib, 10 mM in DMSO;(4R)-4-{3-[(1S)-1-{4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl}ethyl]-5-chloro-2-ethoxy-6-fluorophenyl}pyrrolidin-2-one;2-Pyrrolidinone, 4-[3-[(1S)-1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl]-5-chloro-2-ethoxy-6-fluorophenyl]-, (4R)-;inhibit,INCB-050465,Parsaclisib,Phosphoinositide 3-kinase,relapsed,INCB 050465,refractory,malignancies,PI3K,Inhibitor,PI3Kδ,B-cell
CBNumber
CB54668326
Molecular Formula
C20H22ClFN6O2
Formula Weight
432.88
MOL File
1426698-88-5.mol
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Parsaclisib Property

Boiling point:
650.9±55.0 °C(Predicted)
Density 
1.54±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO : 125 mg/mL (288.76 mM)
form 
Solid
pka
15?+-.0.40(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0033435
Product name
Parsaclisib
Purity
99.31%
Packaging
5mg
Price
$550
Updated
2021/12/16
ChemScene
Product number
CS-0033435
Product name
Parsaclisib
Purity
99.31%
Packaging
10mg
Price
$850
Updated
2021/12/16
ChemScene
Product number
CS-0033435
Product name
Parsaclisib
Purity
99.31%
Packaging
25mg
Price
$1750
Updated
2021/12/16
ChemScene
Product number
CS-0033435
Product name
Parsaclisib
Purity
99.31%
Packaging
50mg
Price
$2750
Updated
2021/12/16
ChemScene
Product number
CS-0033435
Product name
Parsaclisib
Purity
99.31%
Packaging
100mg
Price
$3950
Updated
2021/12/16
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Parsaclisib Chemical Properties,Usage,Production

Uses

Parsaclisib (INCB050465) is a potent, selective and orally active inhibitor of PI3Kδ, with an IC50 of 1 nM at 1 mM ATP. Parsaclisib shows approximately 20000-fold selectivity over other PI3K class I isoforms. Parsaclisib can be used for the research of relapsed or refractory B-cell malignancies[1][2][3].

in vivo

Parsaclisib (10 mg/kg; oral gavage twice daily for 7-19 days) inhibits tumor growth in the BALB/c mice bearing the A20 murine lymphoma cells[2].
Parsaclisib (0.1-10 mg/kg; p.o. twice daily) slows Pfeiffer xenograft tumor growth in a dose-dependent manner. And Parsaclisib was well tolerated[2].
Parsaclisib (0.5-1 mg/kg; a single p.o.) inhibits pAKT (Ser473) in Pfeiffer subcutaneous mouse xenograft models[2].

Animal Model:Female BALB/c mice (5-9 weeks) were inoculated with A20 cells[2]
Dosage:10 mg/kg
Administration:Oral gavage twice daily for 7-19 days
Result:Resulted in significant tumor growth inhibition (TGI).
Reduced the percentage of Tregs (CD4+CD25+FOXP3+) in tumors and spleens.
Increased the ratio of CD4+ and CD8+ T cells to Tregs in spleens and tumors.
Decreased the number of CD4+CD44high and CD8+CD44high T cells in both spleens and tumors.

IC 50

PI3Kδ: 1 nM (IC50)

References

[1] Niu Shin, et al. Abstract 2671: INCB050465, a novel PI3Kδ inhibitor, synergizes with PIM protein kinase inhibition to cause tumor regression in a model of DLBCL. Cancer Research. 2015, Aug. 75(15).
[2] Shin N, et, al. Parsaclisib Is a Next-Generation Phosphoinositide 3-Kinase δ Inhibitor with Reduced Hepatotoxicity and Potent Antitumor and Immunomodulatory Activities in Models of B-Cell Malignancy. J Pharmacol Exp Ther. 2020 Jul;374(1):211-222. DOI:10.1124/jpet.120.265538
[3] Yue EW, et, al. INCB050465 (Parsaclisib), a Novel Next-Generation Inhibitor of Phosphoinositide 3-Kinase Delta (PI3Kδ). ACS Med Chem Lett. 2019 Oct 17;10(11):1554-1560. DOI:10.1021/acsmedchemlett.9b00334

Parsaclisib Preparation Products And Raw materials

Raw materials

Preparation Products

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Parsaclisib Suppliers

China 33 United States 2 Global 35
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
16077
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64
Sichuan Wei Keqi Biological Technology Co., Ltd.
Tel
028-81700200 18116577057
Fax
028-81705658
Email
3003855609@qq.com
Country
China
ProdList
7778
Advantage
56
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4768
Advantage
55
Chuzhou KeMail Chemical Technology Co., Ltd
Tel
0550-5196001 15000891977
Fax
0550-5196001
Email
wj520wjxby@126.com
Country
China
ProdList
1944
Advantage
55
Syntechem Co.,Ltd.
Tel
519-88298820 15861130028
Fax
86-519-83850735
Email
info@syntechem.com
Country
China
ProdList
242
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58
Shanghai Yimiao Pharmaceutical Technology Co., Ltd.
Tel
18717991116
Fax
-
Email
1605896178@qq.com
Country
China
ProdList
250
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
Zhejiang J&C Biological Technology Co.,Limited
Tel
+1-2135480471
Email
sales@sarms4muscle.com
Country
China
ProdList
10473
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58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
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58
ShangHai ChuanQian Chemcial Technique Centre
Tel
15869524721
Email
3525679403@qq.com
Country
China
ProdList
4989
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58

1426698-88-5, ParsaclisibRelated Search:


  • (4R)-4-{3-[(1S)-1-{4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl}ethyl]-5-chloro-2-ethoxy-6-fluorophenyl}pyrrolidin-2-one
  • Parsaclisib
  • 2-Pyrrolidinone, 4-[3-[(1S)-1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl]-5-chloro-2-ethoxy-6-fluorophenyl]-, (4R)-
  • Parsaclisib(INCB050465)
  • inhibit,INCB-050465,Parsaclisib,Phosphoinositide 3-kinase,relapsed,INCB 050465,refractory,malignancies,PI3K,Inhibitor,PI3Kδ,B-cell
  • Parsaclisib, 10 mM in DMSO
  • 1426698-88-5