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R243

Product Name
R243
CAS No.
688352-84-3
Chemical Name
R243
Synonyms
R243;R243, 10 mM in DMSO;CCR,CC chemokine receptor,inhibit,R243,Inhibitor;6H-1,3-Dioxolo[4,5-g][1,3]benzoxazine, 7,8-dihydro-7-[2-(tricyclo[3.3.1.13,7]dec-1-yloxy)ethyl]-;7,8-Dihydro-7-[2-(tricyclo[3.3.1.1(3,7)]dec-1-yloxy)ethyl]- 6H-1,3-dioxolo[4,5-g][1,3]benzoxazine;7-(2-((3S,5S,7S)-Adamantan-1-yloxy)ethyl)-7,8-dihydro-6H-[1,3]dioxolo[4',5':4,5]benzo[1,2-E][1,3]oxazine
CBNumber
CB54668427
Molecular Formula
C21H27NO4
Formula Weight
357.44
MOL File
688352-84-3.mol
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R243 Property

Boiling point:
479.7±45.0 °C(Predicted)
Density 
1.30±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO : 125 mg/mL (349.71 mM; Need ultrasonic)
pka
4.81±0.20(Predicted)
form 
Solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
R729045
Product name
R243
Packaging
5mg
Price
$160
Updated
2021/12/16
ChemScene
Product number
CS-0082741
Product name
R243
Purity
98.90%
Packaging
25mg
Price
$280
Updated
2021/12/16
ChemScene
Product number
CS-0082741
Product name
R243
Purity
98.90%
Packaging
50mg
Price
$450
Updated
2021/12/16
ChemScene
Product number
CS-0082741
Product name
R243
Purity
98.90%
Packaging
100mg
Price
$750
Updated
2021/12/16
ChemScene
Product number
CS-0082741
Product name
R243
Purity
98.90%
Packaging
5mg
Price
$90
Updated
2021/12/16
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R243 Chemical Properties,Usage,Production

Uses

R243 is a potent and selective CCR8 antagonist. R243 inhibits CCL1/CCR8 interaction and inhibits CCR8 signaling and chemotaxis. R243 has antinociceptive and anti-inflammatory effects[1][2].

in vivo

R243 (0.1-1 mg/kg; intraperitoneal injection; once; male Swiss mice) treatment inhibits the analgesic effect evoked by CCL1 in a dose-dependent manner[2].

Animal Model:Male Swiss mice (7-9 weeks old) injected with CCL1[2]
Dosage:0.1 mg/kg, 0.3mg/kg, 1 mg/kg
Administration: Intraperitoneal injection; once
Result:The analgesic effect evoked by CCL1 (10 μg/kg; 1 h; s.c.) was dose-dependently inhibited.

IC 50

CCR8

References

[1] Tomoyuki Oshio, et al. Chemokine Receptor CCR8 Is Required for Lipopolysaccharide-Triggered Cytokine Production in Mouse Peritoneal Macrophages. PLoS One. 2014 Apr 8;9(4):e94445. DOI:10.1371/journal.pone.0094445
[2] Mario García-Domínguez, et al. The Systemic Administration of the Chemokine CCL1 Evokes Thermal Analgesia in Mice Through the Activation of the Endocannabinoid System. Cell Mol Neurobiol. 2019 Nov;39(8):1115-1124. DOI:10.1007/s10571-019-00706-3

R243 Preparation Products And Raw materials

Raw materials

Preparation Products

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R243 Suppliers

China 41 United States 2 Global 43
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4817
Advantage
55
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
86249
Advantage
60
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
7999
Advantage
62
Shanghai Chaolan Chemical Technology Center
Tel
021-QQ：65489617 15618227136
Fax
21-5161 9052
Email
Sales@ATKchemical.com
Country
China
ProdList
9505
Advantage
58
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 18101056239
Email
3193328036@qq.com
Country
China
ProdList
29661
Advantage
68
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32467
Advantage
58
Career Henan Chemica Co
Tel
+86-0371-86658258 +8613203830695
Fax
0371-86658258
Email
laboratory@coreychem.com
Country
China
ProdList
30227
Advantage
58
Changzhou Chenhong Biotechnology Co., Ltd.
Tel
+86-0519-85788828 +86-13775037613
Email
sales@chemrenpharm.com
Country
China
ProdList
4032
Advantage
58
Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd
Tel
15317229551
Fax
QQ:3607245178
Email
15151849396@163.com
Country
China
ProdList
999
Advantage
58

688352-84-3, R243Related Search:


  • R243
  • 6H-1,3-Dioxolo[4,5-g][1,3]benzoxazine, 7,8-dihydro-7-[2-(tricyclo[3.3.1.13,7]dec-1-yloxy)ethyl]-
  • 7,8-Dihydro-7-[2-(tricyclo[3.3.1.1(3,7)]dec-1-yloxy)ethyl]- 6H-1,3-dioxolo[4,5-g][1,3]benzoxazine
  • CCR,CC chemokine receptor,inhibit,R243,Inhibitor
  • R243, 10 mM in DMSO
  • 7-(2-((3S,5S,7S)-Adamantan-1-yloxy)ethyl)-7,8-dihydro-6H-[1,3]dioxolo[4',5':4,5]benzo[1,2-E][1,3]oxazine
  • 688352-84-3