Ani9
- Product Name
- Ani9
- CAS No.
- 356102-14-2
- Chemical Name
- Ani9
- Synonyms
- Ani9;Ani9, 10 mM in DMSO;2-(4-Chloro-2-methylphenoxy)-N'-(2-methoxybenzylidene)acetohydrazide;Acetic acid, 2-(4-chloro-2-methylphenoxy)-, 2-[(2-methoxyphenyl)methylene]hydrazide
- CBNumber
- CB54669000
- Molecular Formula
- C17H17ClN2O3
- Formula Weight
- 332.78
- MOL File
- 356102-14-2.mol
Ani9 Property
- Density
- 1.20±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: 25 mg/ml
- form
- powder
- pka
- 11.73±0.46(Predicted)
- color
- white to beige
N-Bromosuccinimide Price
- Product number
- SML1813
- Product name
- Ani9
- Packaging
- 5MG
- Price
- $111.15
- Updated
- 2025/07/31
- Product number
- SML1813
- Product name
- Ani9
- Packaging
- 25MG
- Price
- $477
- Updated
- 2025/07/31
- Product number
- 29733
- Product name
- Ani 9
- Packaging
- 1mg
- Price
- $40
- Updated
- 2024/03/01
- Product number
- 29733
- Product name
- Ani 9
- Packaging
- 5mg
- Price
- $109
- Updated
- 2024/03/01
- Product number
- 29733
- Product name
- Ani 9
- Packaging
- 10mg
- Price
- $197
- Updated
- 2024/03/01
Ani9 Chemical Properties,Usage,Production
Description
Ani 9 is an inhibitor of the calcium-activated chloride channel (CaCC) anoctamin 1 (ANO1) that blocks ATP-induced apical membrane chloride currents in ANO1-expressing Fischer rat thyroid (FRT) cells (IC50 = 77 nM). It is selective for ANO1 over ANO2 at 10 μM and the cystic fibrosis transmembrane conductance regulator (CFTR) and epithelial sodium channel (ENaC) at 30 μM. Ani 9 inhibits ATP-induced quenching of a fluorescent intracellular halide sensor in PC3 prostate cancer cells and Capan-1 pancreatic carcinoma cells in a concentration-dependent manner.
Uses
Ani9 has been used to find out the inappropriate modulation of the membrane protein functions that are involved in the 198 ADGRG2- or Gq-mediated regulation of fluid reabsorption in the efferent ductules.
Uses
(4-Chloro-2-methylphenoxy)-[(2-methoxyphenyl)methylene]hydrazide Acetic Acid inhibits anoctamin1/transmembrane protein 16A, a calcium-activated chloride channel involved in fluid secretion, smooth muscle contraction, nociception and cancer progression.
Biochem/physiol Actions
2-(4-chloro-2-methylphenoxy)-N-[(2-methoxyphenyl)methylideneamino]-acetamide (Ani9), the most potent inhibitor, is the structural analog of Ani7. It may be considered as a novel candidate for drug therapy of cancer, hypertension, pain, diarrhea and asthma.
storage
Store at -20°C
References
[1] YOHAN SEO. Ani9, A Novel Potent Small-Molecule ANO1 Inhibitor with Negligible Effect on ANO2.[J]. PLoS ONE, 2016: e0155771. DOI: 10.1371/journal.pone.0155771
Ani9 Preparation Products And Raw materials
Raw materials
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