ChemicalBook > CAS DataBase List > LMT-28

LMT-28

Product Name: LMT-28
CAS No.: 1239600-18-0
Chemical Name: LMT-28
Synonyms: LMT-28;LMT28,LMT 28;LMT-28 >=98% (HPLC);LMT-28, 10 mM in DMSO;(S)-3-((2S,3S)-3-Hydroxy-2-methyl-4-methylenenonanoyl)-4-isopropyloxazolidin-2-one;2-Oxazolidinone, 3-[(2S,3S)-3-hydroxy-2-methyl-4-methylene-1-oxononyl]-4-(1-methylethyl)-, (4S)-
CBNumber: CB54670121
Molecular Formula: C17H29NO4
Formula Weight: 311.42
MOL File: 1239600-18-0.mol

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LMT-28 Property

Boiling point:: 452.9±38.0 °C(Predicted)
Density: 1.065±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: 100 mg/mL in DMSO (321.11 mM),
pka: 13.97±0.20(Predicted)
form: oil
color: colorless to light yellow, oil
Water Solubility: < 0.1 mg/mL Water (insoluble)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1628
Product name: LMT-28
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $111
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML1628
Product name: LMT-28
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $447
Updated: 2025/07/31

ChemScene

Product number: CS-0022963
Product name: LMT-28
Purity: 98.85%
Packaging: 50mg
Price: $500
Updated: 2021/12/16

ChemScene

Product number: CS-0022963
Product name: LMT-28
Purity: 98.85%
Packaging: 100mg
Price: $850
Updated: 2021/12/16

ChemScene

Product number: CS-0022963
Product name: LMT-28
Purity: 98.85%
Packaging: 10mg
Price: $140
Updated: 2021/12/16

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LMT-28 Chemical Properties,Usage,Production

Uses

LMT-28 is an orally active and the first synthetic IL-6 inhibitor that functions through direct binding to gp130. LMT-28 shows low toxicity and selectively inhibits IL-6-induced phosphorylation of STAT3, JAK2, and gp130[1].

Biochem/physiol Actions

LMT-28 is a derivative of oxazolidinone. It has the ability to repress the activation of signal transducer and activator of transcription 3 (STAT3) stimulated by interleukin 6 (IL-6). Orally administered LMT-28 reduced arthritis and acute pancreatitis stimulated by collagen in mice pathologic models.

in vivo

LMT-28 (0-0.5 mg/kg; p.o.; once daily for 15 days) alleviates CIA in mice^[1].
LMT-28 (0.25 or 1 mg/kg; p.o.) ameliorates the progression of pancreatitis in mice. LMT-28 binds directly and specifically to gp130, and thereby inhibits the interaction of gp130 with the IL-6/IL-6Rα complex^[1].

Animal Model:	Six-week-old male DBA/1J mice (collagen-induced arthritis mice, CIA)^[1]
Dosage:	0-0.5 mg/kg
Administration:	Oral; once daily for 15 days
Result:	Markedly reduced the serum levels of cartilage oligomeric matrix protein (COMP) by 50%, serum amyloid P (SAP) by 55%, and anti-CII IgG by 62%.

IC 50

IL-6

References

[1] Hong SS, et al. A Novel Small-Molecule Inhibitor Targeting the IL-6 Receptor β Subunit, Glycoprotein 130. J Immunol. 2015 Jul 1;195(1):237-45. DOI:10.4049/jimmunol.1402908

LMT-28 Preparation Products And Raw materials

Raw materials

Preparation Products

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LMT-28 Suppliers

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1239600-18-0, LMT-28Related Search:

LMT-28

2-Oxazolidinone, 3-[(2S,3S)-3-hydroxy-2-methyl-4-methylene-1-oxononyl]-4-(1-methylethyl)-, (4S)-

LMT-28 >=98% (HPLC)

LMT28,LMT 28

LMT-28, 10 mM in DMSO

(S)-3-((2S,3S)-3-Hydroxy-2-methyl-4-methylenenonanoyl)-4-isopropyloxazolidin-2-one

1239600-18-0