Sparstolonin B

Product Name: Sparstolonin B
CAS No.: 1259330-61-4
Chemical Name: Sparstolonin B
Synonyms: Sparstolonin B;Sparstolonin B (SsnB);Sparstolonin B >=98% (HPLC);3H-Pyrano[3,4,5-kl]xanthen-3-one, 4,10-dihydroxy-
CBNumber: CB54670606
Molecular Formula: C15H8O5
Formula Weight: 268.22
MOL File: 1259330-61-4.mol

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Sparstolonin B Property

storage temp.: 2-8°C
solubility: DMSO : 10 mg/mL (Need ultrasonic and warming)
form: powder
color: white to beige

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1767
Product name: Sparstolonin B
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $117
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML1767
Product name: Sparstolonin B
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $477
Updated: 2025/07/31

ChemScene

Product number: CS-0064377
Product name: SparstoloninB
Purity: ≥99.0%
Packaging: 5mg
Price: $210
Updated: 2021/12/16

ChemScene

Product number: CS-0064377
Product name: SparstoloninB
Purity: ≥99.0%
Packaging: 10mg
Price: $350
Updated: 2021/12/16

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Sparstolonin B Chemical Properties,Usage,Production

Uses

Sparstolonin B acts as a selective TLR2 and TLR4 antagonist and selectively blocks TLR2- and TLR4-mediated inflammatory signaling. Sparstolonin B has anti-HIV and anticancer activities[1][2].

Biochem/physiol Actions

Sparstolonin B (SsnB) is a polyphenol. It has a structural features similar to xanthone and isocoumarin. SsnB exerts anti-inflammatory properties on mouse and human macrophages. SsnB can significantly reduce hypoxia–reoxygenation-induced inflammation of cardiomyocytes by blocking extracellular signal-regulated protein kinase (ERK1/2) and c-jun N-terminal kinases (JNK) signaling pathways. Thus, SsnB acts as a potent therapeutic for the treatment of myocardial ischemia–reperfusion (MIR) injury.

in vivo

Sparstolonin B (100 μg/mouse; i.p.) suppresses LPS-provoked inflammation in mice^[1].

Animal Model:	5-6-week-old male C57Bl/6 mice (body weight 18-20 g)^[1]
Dosage:	100 μg/mouse
Administration:	I.p.
Result:	Significantly lower TNFα and IL-1β expression levels in LPS-induced sepsis mouse model.

IC 50

TLR2; TLR4; HIV-1

References

[1] Liang Q, et al. Characterization of sparstolonin B, a Chinese herb-derived compound, as a selective Toll-like receptor antagonist with potent anti-inflammatory properties. J Biol Chem. 2011;286(30):26470-26479. DOI:10.1074/jbc.M111.227934
[2] Deng X, et al. The Chinese herb-derived Sparstolonin B suppresses HIV-1 transcription. Virol J. 2015;12:108. Published 2015 Jul 25. DOI:10.1186/s12985-015-0339-8
[3] Kumar A, et al. Sparstolonin B, a novel plant derived compound, arrests cell cycle and induces apoptosis in N-myc amplified and N-myc nonamplified neuroblastoma cells [published correction appears in PLoS One. 2016;11(7):e0159082]. PLoS One. 2014;9(5):e96343. Published 2014 May 1. DOI:10.1371/journal.pone.0096343

Sparstolonin B Preparation Products And Raw materials

Raw materials

Preparation Products

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1259330-61-4, Sparstolonin BRelated Search:

Sparstolonin B

3H-Pyrano[3,4,5-kl]xanthen-3-one, 4,10-dihydroxy-

Sparstolonin B >=98% (HPLC)

Sparstolonin B (SsnB)

1259330-61-4