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SHIN1

Product Name: SHIN1
CAS No.: 2146095-85-2
Chemical Name: SHIN1
Synonyms: SHIN1;RZ-2994;SHIN 1New;SHIN1(RZ-2994);SHIN1, 10 mM in DMSO;SHIN1,RZ2994,SHIN-1,RZ 2994,Inhibitor,SHIN 1,inhibit;{5-[6-amino-3,5-dimethyl-4-(propan-2-yl)-1H,4H-pyrano[2,3-c]pyrazol-4-yl]-[1,1'-biphenyl]-3-yl}methanol;6-amino-4-(5-(hydroxymethyl)-[1,1'-biphenyl]-3-yl)-4-isopropyl-3-methyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile;6-Amino-4-(5-(hydroxymethyl)-[1,1'-biphenyl]-3-yl)-4-isopropyl-3-methyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile;6-Amino-1,4-dihydro-4-[5-(hydroxymethyl)[1,1'-biphenyl]-3-yl]-3-methyl-4-(1-methylethyl)pyrano[2,3-c]pyrazole-5-carbonitrile
CBNumber: CB54672640
Molecular Formula: C24H24N4O2
Formula Weight: 400.47
MOL File: 2146095-85-2.mol

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SHIN1 Property

Boiling point:: 683.6±55.0 °C(Predicted)
Density: 1.32±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: soluble
form: A solid
pka: 11.54±0.70(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris

Product number: 6998
Product name: SHIN1
Purity: ≥98%(HPLC)
Packaging: 5
Price: $319
Updated: 2021/12/16

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SHIN1 Chemical Properties,Usage,Production

Uses

SHIN1 (RZ-2994) is a human serine hydroxymethyltransferse 1 and 2 (SHMT1/2) inhibitor with IC50s of 5 and 13 nM, respectively, in an in vitro assay.

storage

Store at -20°C

References

[1] Ducker GS, et al. Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma. Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):11404-11409. DOI:10.1073/pnas.1706617114

SHIN1 Preparation Products And Raw materials

Raw materials

Preparation Products

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2146095-85-2, SHIN1Related Search:

SHIN1

Pyrano[2,3-c]pyrazole-5-carbonitrile, 6-amino-1,4-dihydro-4-[5-(hydroxymethyl)[1,1'-biphenyl]-3-yl]-3-methyl-4-(1-methylethyl)-

RZ-2994

SHIN1,RZ2994,SHIN-1,RZ 2994,Inhibitor,SHIN 1,inhibit

6-Amino-4-(5-(hydroxymethyl)-[1,1'-biphenyl]-3-yl)-4-isopropyl-3-methyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

{5-[6-amino-3,5-dimethyl-4-(propan-2-yl)-1H,4H-pyrano[2,3-c]pyrazol-4-yl]-[1,1'-biphenyl]-3-yl}methanol

SHIN1, 10 mM in DMSO

6-amino-4-(5-(hydroxymethyl)-[1,1'-biphenyl]-3-yl)-4-isopropyl-3-methyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

SHIN 1New

SHIN1(RZ-2994)

6-Amino-1,4-dihydro-4-[5-(hydroxymethyl)[1,1'-biphenyl]-3-yl]-3-methyl-4-(1-methylethyl)pyrano[2,3-c]pyrazole-5-carbonitrile

2146095-85-2