GLX351322

Product Name: GLX351322
CAS No.: 835598-94-2
Chemical Name: GLX351322
Synonyms: CS-2871;GLX 351322;GLX-351322;GLX351322,GLX-351322,GLX 351322,NADPH Oxidase,NOX,Inhibitor,inhibit;Ethyl 2-(2-(4-(furan-2-carbonyl)piperazin-1-yl)acetamido)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate;4H-Cyclopenta[b]thiophene-3-carboxylic acid, 2-[[2-[4-(2-furanylcarbonyl)-1-piperazinyl]acetyl]amino]-5,6-dihydro-, ethyl ester
CBNumber: CB54672882
Molecular Formula: C21H25N3O5S
Formula Weight: 431.51
MOL File: 835598-94-2.mol

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GLX351322 Property

solubility: DMSO:20.0(Max Conc. mg/mL);46.35(Max Conc. mM)
DMF:1.0(Max Conc. mg/mL);2.32(Max Conc. mM)
DMF:PBS (pH 7.2) (1:2):0.33(Max Conc. mg/mL);0.76(Max Conc. mM)
Ethanol:4.0(Max Conc. mg/mL);9.27(Max Conc. mM)
form: A crystalline solid

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Safety

HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2546
Product name: GLX351322
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $95.3
Updated: 2023/06/20

Sigma-Aldrich

Product number: SML2546
Product name: GLX351322
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $385
Updated: 2023/06/20

ChemScene

Product number: CS-0018088
Product name: GLX351322
Purity: 99.48%
Packaging: 25mg
Price: $500
Updated: 2021/12/16

ChemScene

Product number: CS-0018088
Product name: GLX351322
Purity: 99.48%
Packaging: 5mg
Price: $150
Updated: 2021/12/16

ChemScene

Product number: CS-0018088
Product name: GLX351322
Purity: 99.48%
Packaging: 50mg
Price: $850
Updated: 2021/12/16

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GLX351322 Chemical Properties,Usage,Production

Biological Activity

GLX351322 is an inhibitor of NADPH oxidase 4 (NOX4). It can inhibits tetracycline-induced hydrogen peroxide production in NOX4-overexpressing cells with IC50 of 5 μM.

in vitro

GLX351322 is an inhibitor of NADPH oxidase 4, and inhibits hydrogen peroxide production from NOX4-overexpressing cells with an IC ₅₀ of 5 μM. GLX351322 shows weak activity against NOX2 in hPBMC cells ( IC ₅₀ , 40 μM).

in vivo

GLX351322 (3.8 mg/kg/day, po) ameliorates HFD-induced hyperglycemia in mice.

target

Target	Value
NOX4 (Cell-free assay)	5 μM

GLX351322 Preparation Products And Raw materials

Raw materials

Preparation Products

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GLX351322 Suppliers

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835598-94-2, GLX351322Related Search:

CS-2871

GLX 351322;GLX-351322

4H-Cyclopenta[b]thiophene-3-carboxylic acid, 2-[[2-[4-(2-furanylcarbonyl)-1-piperazinyl]acetyl]amino]-5,6-dihydro-, ethyl ester

GLX351322,GLX-351322,GLX 351322,NADPH Oxidase,NOX,Inhibitor,inhibit

Ethyl 2-(2-(4-(furan-2-carbonyl)piperazin-1-yl)acetamido)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate

835598-94-2