TH34
- Product Name
- TH34
- CAS No.
- 2196203-96-8
- Chemical Name
- TH34
- Synonyms
- TH34;CS-2858;TH34;TH 34;TH34, 10 mM in DMSO;3-(Benzylamino)-N-hydroxy-4-methylbenzamide;Benzamide, N-hydroxy-4-methyl-3-[(phenylmethyl)amino]-;TH34,inhibit,Inhibitor,TH 34,TH-34,HDAC,Histone deacetylases
- CBNumber
- CB54677458
- Molecular Formula
- C15H16N2O2
- Formula Weight
- 256.3
- MOL File
- 2196203-96-8.mol
TH34 Property
- Density
- 1.236±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- DMSO : 150 mg/mL (585.25 mM)
- pka
- 9.04±0.10(Predicted)
- form
- Solid
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CS-0092655
- Product name
- TH34
- Purity
- 99.05%
- Packaging
- 5mg
- Price
- $110
- Updated
- 2021/12/16
- Product number
- Axon2996
- Product name
- TH34
- Purity
- 98%
- Packaging
- 10mg
- Price
- $132
- Updated
- 2021/12/16
- Product number
- CS-0092655
- Product name
- TH34
- Purity
- 99.05%
- Packaging
- 10mg
- Price
- $160
- Updated
- 2021/12/16
- Product number
- 6327EL
- Product name
- CID134159676
- Packaging
- 10mg
- Price
- $262
- Updated
- 2021/12/16
- Product number
- CS-0092655
- Product name
- TH34
- Purity
- 99.05%
- Packaging
- 25mg
- Price
- $330
- Updated
- 2021/12/16
TH34 Chemical Properties,Usage,Production
Uses
TH34, an HDAC6/8/10 inhibitor with IC50s of 4.6 μM, 1.9 μM, and 7.7 μM respectively, shows high selectivity over HDAC1/2/3[1].
Biological Activity
TH34 is an HDAC6/8/10 inhibitor with IC50 values of 4.6 μM, 1.9 μM and 7.7 μM, respectively, showing high selectivity compared with HDAC1/2/3.
in vitro
TH34 induces caspase-dependent programmed cell death and cell cycle arrest in neuroblastoma cells.
target
| HDAC6 4.6 μM (IC 50 ) | HDAC8 1.9 μM (IC 50 ) | HDAC10 7.7 μM (IC 50 ) |
IC 50
HDAC6: 4.6 μM (IC50); HDAC8: 1.9 μM (IC50); HDAC10: 7.7 μM (IC50)
References
[1] Kolbinger FR, et al. The HDAC6/8/10 inhibitor TH34 induces DNA damage-mediated cell death in human high-grade neuroblastoma cell lines. Arch Toxicol. 2018 Aug;92(8):2649-2664. DOI:10.1007/s00204-018-2234-8
TH34 Preparation Products And Raw materials
Raw materials
Preparation Products
TH34 Suppliers
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- 400-6206333 13167063860
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- 021-50323701
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- China
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- QQ: 12922499
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- United States
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- 021-65675885 18964387627
- Fax
- 021-65675885
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- 021-61312847; 18021002903
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- QQ:3008007432
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- 021-QQ：65489617 15618227136
- Fax
- 21-5161 9052
- Sales@ATKchemical.com
- Country
- China
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View Lastest Price from TH34 manufacturers
- Product
- TH34 2196203-96-8
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-08