ChemicalBook > CAS DataBase List > 6-Methylthioguanine

6-Methylthioguanine

Product Name
6-Methylthioguanine
CAS No.
1198-47-6
Chemical Name
6-Methylthioguanine
Synonyms
NSC 29420;TIMTEC-BB SBB000228;6-Methylthioguanine;S-Methyl-6-thioguanine;S6-Methyl-6-thioguanine;2-Amino-6-methylthiopurine;Mercaptopurine Impurity 29;6-Methylthioguanine USP/EP/BP;2-AMINO-6-METHYLMERCAPTOPURINE;6-Methylthio-7H-purine-2-amine
CBNumber
CB5468494
Molecular Formula
C6H7N5S
Formula Weight
181.22
MOL File
1198-47-6.mol
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6-Methylthioguanine Property

Melting point:
235.5°C
Density 
1.403 (estimate)
refractive index 
1.4606 (estimate)
storage temp. 
-20°C Freezer
solubility 
DMSO (Slightly), Methanol (Slightly, Sonicated)
form 
solid
color 
White to Off-White
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Safety

Hazard Codes 
Xn
Risk Statements 
22-37/38-41
Safety Statements 
24/25-39-26
WGK Germany 
3
HS Code 
29335995
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A9546
Product name
2-Amino-6-methylmercaptopurine
Purity
≥95%
Packaging
100mg
Price
$126
Updated
2024/03/01
Usbiological
Product number
017448
Product name
6-Methylthioguanine
Packaging
250mg
Price
$496
Updated
2021/12/16
TRC
Product number
M330720
Product name
6-Methylthioguanine
Packaging
1g
Price
$660
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0027598
Product name
2-AMINO-6-METHYLMERCAPTOPURINE
Purity
95.00%
Packaging
250MG
Price
$779.63
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0027598
Product name
2-AMINO-6-METHYLMERCAPTOPURINE
Purity
95.00%
Packaging
2.5G
Price
$2255
Updated
2021/12/16
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6-Methylthioguanine Chemical Properties,Usage,Production

Chemical Properties

off-white crystalline powder

Uses

2-Amino-6-methylmercaptopurine is a 2-amino-6-alkyldithiopurine that has been used with other 6-position carbon analogues to study brain specific diazepam binding.

Uses

As a metabolite of 2’-Deoxy-6-thio Guanosine (D281650) and 6-Thioguanine, 6-Methylthioguanine can be used as an effective immunosuppressant and anticancer agent, however chronic exposure can be mutagenic in human cells as long-term use of thiopurines was found to be associated with a significantly increased risk of various types of cancer.

Definition

ChEBI: 6-methylthioguanine is a metabolite of thioguanine, a drug used in cancer chemotherapy. It has a role as a human xenobiotic metabolite. It is a member of 2-aminopurines and a thiopurine. It is functionally related to a tioguanine.

Biochem/physiol Actions

2-Amino-6-methylmercaptopurine is synthesized from 6-mercaptopurine by the S methylation activity of thiopurine methyl transferase (TMPT) enzyme.

6-Methylthioguanine Preparation Products And Raw materials

Raw materials

Preparation Products

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1198-47-6, 6-MethylthioguanineRelated Search:

8-AZA-6-HYDROXY-2-MERCAPTOPURINE 6-thioinosine-5'-triphosphate 6,8-DIHYDROXY-2-METHYLMERCAPTOPURINE 2-Amino-6-mercaptopurine-13C2,15N 6-N-HEPTYLMERCAPTOPURINE 1,9-DIHYDRO-6H-PURINE-6-THIONE 2-AMINO-9-(2,3,5-TRI-O-ACETYL-BETA-D-RIBOFURANOSYL)-6-THIOPURINE 6-(Methylthio)purine 2-AMINO-6-HYDROXY-8-MERCAPTOPURINE 1,7,8,9-tetrahydro-8-thioxo-6H-purin-6-one 6-METHYLMERCAPTOPURINE RIBOSIDE 6-Thioguanosine hydrate 2-MERCAPTOPURINE 6-METHYL-D3-MERCAPTOPURINE 2,6-Dithiopurine 1H-Imidazole-4-carboxylic acid 6-thioinosine 5'-monophosphate 6-thioinosine 2',3',5'-triacetate

  • 1H-Purin-2-amine, 6-(methylthio)-
  • 2-Amino-6-methylthiopurine
  • 6-(Methylsulfanyl)-1H-purin-2-amine
  • 6-Methylthioguanine
  • TIMTEC-BB SBB000228
  • 6-(METHYLSULFANYL)-7H-PURIN-2-YLAMINE
  • 2-AMINO-6-METHYLMERCAPTOPURINE
  • 2-AMINO-6-METHYLMERCAPTOPURINE 95%
  • 2-Amino-6-(methylthio)-9H-purine
  • 6-(Methylthio)-9H-purine-2-amine
  • 6-Methylthio-7H-purine-2-amine
  • 2-Amino-6-methylmercaptopurine,95%
  • NSC 29420
  • S6-Methyl-6-thioguanine
  • S-Methyl-6-thioguanine
  • 6-(methylthio)-1H-purin-2-amine
  • 2-Amino-6-methylmercaptopurine-[13C, d3] (Solution)
  • 9H-Purin-2-amine, 6-(methylthio)-
  • Mercaptopurine Impurity 29
  • 6-Methylthioguanine USP/EP/BP
  • 6-(methylsulfanyl)-7H-purin-2-amine
  • 6-(Methylthio)-7H-purin-2-amine
  • 1198-47-6
  • C6H7N5S
  • Biochemicals and Reagents
  • BioChemical
  • Nucleoside Analogs
  • Nucleosides, Nucleotides, Oligonucleotides
  • Heterocycles, Metabolites & Impurities, Nucleotides, Bases & Related Reagents, Mutagenesis Research Chemicals, Sulfur & Selenium Compounds
  • Bases & Related Reagents
  • Heterocycles
  • Metabolites & Impurities
  • Mutagenesis Research Chemicals
  • Nucleotides
  • Sulfur & Selenium Compounds